Role of connective tissue proteases in the pathogenesis of chronic inflammatory lung disease.

Laminin–a glycoprotein from basement membranes.

1979 • 2,372 citations

Fibronectins—adhesive glycoproteins of cell surface and blood

1978 • 1,418 citations

The Electrophoretic α;₁-Globulin Pattern of Serum in α;₁-Antitrypsin Deficiency

1963 • 1,400 citations

Inflammatory and immune processes in the human lung in health and disease: evaluation by bronchoalveolar lavage.

1979 • 958 citations

Idiopathic Pulmonary Fibrosis

1976 • 706 citations

Interstitial lung disease: Current concepts of pathogenesis, staging and therapy

1981 • 549 citations

Elastase secretion by stimulated macrophages. Characterization and regulation.

1975 • 522 citations

Chemotactic activity of elastin-derived peptides.

1980 • 519 citations

Antielastases of the human alveolar structures. Implications for the protease-antiprotease theory of emphysema.

1981 • 441 citations

Animal Models of Emphysema^1–3

1986 • 439 citations

Cigarette Smoking Induces Functional Antiprotease Deficiency in the Lower Respiratory Tract of Humans

1979 • 398 citations

Possible mechanisms of emphysema in smokers. In vitro suppression of serum elastase-inhibitory capacity by fresh cigarette smoke and its prevention by antioxidants.

1978 • 364 citations

Experimental Emphysema

1965 • 360 citations

The Induction of Pulmonary Emphysema with Human Leukocyte Elastase^1–3

1977 • 335 citations

Experimental emphysema induced with purified human neutrophil elastase: tissue localization of the instilled protease.

1977 • 284 citations

Degradation of type IV (basement membrane) collagen by a proteinase isolated from human polymorphonuclear leukocyte granules.

1980 • 279 citations

Human Alveolar Macrophage-derived Chemotactic Factor for Neutrophils

1980 • 253 citations

Mechanisms of neutrophil accumulation in the lungs of patients with idiopathic pulmonary fibrosis.

1981 • 235 citations

The Chemistry and Biology of Collagen

1979 • 222 citations

[52] Mammalian collagenases

1981 • 219 citations

Cigarette Smoke Inhalation Decreases α ₁ -Antitrypsin Activity in Rat Lung

1979 • 206 citations

Elastin Fragments Attract Macrophage Precursors to Diseased Sites in Pulmonary Emphysema

1981 • 205 citations

Collagenase in the Lower Respiratory Tract of Patients with Idiopathic Pulmonary Fibrosis

1979 • 205 citations

Granulocyte collagenase: selective digestion of type I relative to type III collagen.

1977 • 201 citations

The degradation of articular collagen by neutrophil proteinases

1977 • 189 citations

Lung injury induced by leukocytic proteases.

1979 • 183 citations

The connective tissue of lung.

1975 • 173 citations

Plasma proteins of the bronchoalveolar surface of the lungs of smokers and nonsmokers.

1981 • 169 citations

Small molecular weight β1 serum protein which specifically inhibits human collagenases

1976 • 147 citations

Human neutrophil elastase functions as a type III collagen “Collagenase”

1980 • 137 citations

Elastin and Elastic Tissue

1977 • 136 citations

Analysis of macrophage surface receptors. II. Internalization of alpha-macroglobulin . trypsin complexes by rabbit alveolar macrophages.

1979 • 132 citations

The degradation of human lung elastin by neutrophil proteinases

1980 • 129 citations

Degradation of cartilage proteoglycan by human leukocyte granule neutral proteases--a model of joint injury. I. Penetration of enzyme into rabbit articular cartilage and release of 35SO4-labeled material from the tissue.

1976 • 127 citations

Specific cleavage of the native Type III collagen molecule with trypsin

1976 • 125 citations

Cleavage of laminin by thrombin and plasmin: Alpha thrombin selectively cleaves the beta chain of laminin

1981 • 121 citations

Destruction of a major extracellular adhesive glycoprotein (fibronectin) of human fibroblasts by neutral proteases from polymorphonuclear leukocyte granules.

1979 • 117 citations

Receptor-mediated binding and internalization of leukocyte elastase by alveolar macrophages in vitro.

1979 • 116 citations

Isolation and tissue localization of type AB2 collagen from normal lung parenchyma.

1979 • 110 citations

Type-specific collagenolysis: A type V collagen-degrading enzyme from macrophages

1980 • 106 citations

Possible mechanisms of emphysema in smokers: cigarette smoke condensate suppresses protease inhibition in vitro.

1977 • 98 citations

Secretion of alpha-2-macroglobulin by human alveolar macrophages

1980 • 98 citations

Lung Connective Tissue

1983 • 90 citations

Acute inflammatory pulmonary reactions induced by chemotactic factors.

1979 • 89 citations

Activation of alveolar macrophage collagenase by a neutral protease secreted by the same cell

1976 • 78 citations

Regulation of the release of alveolar macrophage-derived neutrophil chemotactic factor.

1980 • 77 citations

EVALUATION OF THE PROTEASE-ANTIPROTEASE THEORY OF HUMAN DESTRUCTIVE LUNG DISEASE

1981 • 67 citations

Content and synthesis of glycosaminoglycans in the developing lung.

1975 • 59 citations

Chapter 3 The Fibroblast of Human Lung Alveolar Structures: A Differentiated Cell with a Major Role in Lung Structure and Function

1980 • 55 citations

Mechanism by which Cigarette Smoke Attracts Polymorphonuclear Leukocytes to Lung

1980 • 53 citations

Chapter 6 The Human Alveolar Macrophage

1980 • 48 citations

Mammalian Collagenases

1973 • 48 citations

Isolation, purification, and cross-linking profiles of elastin from lung and aorta

1976 • 47 citations

Degradation of Cartilage Proteoglycan by Human Leukocyte Granule Neutral Proteases- A Model of Joint Injury

1976 • 37 citations

Serine protease inhibitors inhibit superoxide production by human polymorphonuclear leukocytes and monocytes stimulated by various surface active agents

1979 • 36 citations

Partial purification and characterization of mouse peritoneal exudative macrophage elastase

1980 • 35 citations

ULTRASTRUCTURAL STAINING OF THIN SECTIONS WITH IRON HEMATOXYLIN

1974 • 35 citations

Neutral proteases of human polymorphonuclear leukocytes: Biochemistry, physiology, and clinical significance

1978 • 31 citations

Pulmonary Asbestosis and Idiopathic Pulmonary Fibrosis: Pathogenetic Parallels

1981 • 23 citations

Mechanism by which Cigarette Smoke Attracts Polymorphonuclear Leukocytes to Lung

1980 • 20 citations

HUMAN ALVEOLAR MACROPHAGE

1972 • 11 citations

Chemotactic Activity ofElastin-derived Peptides

1980 • 7 citations

[Normal and pathological elastic tissue under the electron microscope on thin and ultrathin sections (author's transl)].

1976 • 7 citations