Paxillin: a focal adhesion-associated adaptor protein

FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING

1996 • 1,900 citations

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

Signaling through focal adhesion kinase

1999 • 1,169 citations

Control of adhesion-dependent cell survival by focal adhesion kinase.

1996 • 1,113 citations

Src family kinases are required for integrin but not PDGFR signal transduction

1999 • 733 citations

Paxillin: a new vinculin-binding protein present in focal adhesions.

1990 • 687 citations

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains.

1995 • 620 citations

LIM domains: multiple roles as adapters and functional modifiers in protein interactions

1998 • 592 citations

pp125^FAK-Dependent Tyrosine Phosphorylation of Paxillin Creates a High-Affinity Binding Site for Crk

1995 • 534 citations

Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate

1996 • 522 citations

The role of ARF and Rab GTPases in membrane transport

1999 • 496 citations

A mechanism for regulation of the adhesion-associated protein tyrosine kinase pp125FAK

1996 • 488 citations

Paxillin LD4 Motif Binds PAK and PIX through a Novel 95-kD Ankyrin Repeat, ARF–GAP Protein: A Role in Cytoskeletal Remodeling

1999 • 466 citations

RAFTK/Pyk2-mediated cellular signalling

2000 • 457 citations

Novel tyrosine kinase substrates from Rous sarcoma virus-transformed cells are present in the membrane skeleton.

1989 • 457 citations

Regulators and effectors of the ARF GTPases

2000 • 396 citations

Induced Focal Adhesion Kinase (FAK) Expression in FAK-Null Cells Enhances Cell Spreading and Migration Requiring Both Auto- and Activation Loop Phosphorylation Sites and Inhibits Adhesion-Dependent Tyrosine Phosphorylation of Pyk2

1999 • 395 citations

Coupling of PAK-Interacting Exchange Factor PIX to GIT1 Promotes Focal Complex Disassembly

2000 • 353 citations

Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding.

1996 • 347 citations

Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase.

1995 • 341 citations

Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration

1998 • 339 citations

Characterization of Tyrosine Phosphorylation of Paxillin in Vitro by Focal Adhesion Kinase

1995 • 334 citations

Inhibition of Cell Spreading by Expression of the C-Terminal Domain of Focal Adhesion Kinase (FAK) Is Rescued by Coexpression of Src or Catalytically Inactive FAK: a Role for Paxillin Tyrosine Phosphorylation

1997 • 329 citations

Binding of paxillin to α4 integrins modifies integrin-dependent biological responses

1999 • 326 citations

Specific and redundant roles of Src and Fyn in organizing the cytoskeleton

1995 • 325 citations

Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak- binding region

1994 • 311 citations

Platelet-derived growth factor modulation of focal adhesion kinase (p125FAK) and paxillin tyrosine phosphorylation in Swiss 3T3 cells. Bell-shaped dose response and cross-talk with bombesin.

1994 • 305 citations

Cloning and Characterization of Androgen Receptor Coactivator, ARA55, in Human Prostate

1999 • 290 citations

Protein Tyrosine Phosphatase-PEST Regulates Focal Adhesion Disassembly, Migration, and Cytokinesis in Fibroblasts

1999 • 284 citations

Autonomous Expression of a Noncatalytic Domain of the Focal Adhesion-Associated Protein Tyrosine Kinase pp125^FAK

1993 • 282 citations

Molecular Cloning Of Human Paxillin, a Focal Adhesion Protein Phosphorylated by P210BCR/ABL

1995 • 275 citations

Phosphorylation of Tyrosine Residues 31 and 118 on Paxillin Regulates Cell Migration through an Association with Crk in Nbt-II Cells

2000 • 268 citations

Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK.

1995 • 261 citations

The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton

1997 • 258 citations

Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts.

1993 • 257 citations

Nuclear–Cytoplasmic Shuttling of the Focal Contact Protein, Zyxin: A Potential Mechanism for Communication between Sites of Cell Adhesion and the Nucleus

1997 • 244 citations

Analysis of the binding of the Src homology 2 domain of Csk to tyrosine-phosphorylated proteins in the suppression and mitotic activation of c-Src.

1994 • 230 citations

Cell–substrate interactions and signaling through ILK

2000 • 228 citations

Detection of Src homology 3-binding proteins, including paxillin, in normal and v-Src-transformed Balb/c 3T3 cells

1993 • 222 citations

The Arf GTPase-activating protein ASAP1 regulates the actin cytoskeleton

2000 • 212 citations

Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation of the focal adhesion-associated protein paxillin in Swiss 3T3 cells.

1993 • 209 citations

Integrin-linked Kinase (ILK) Binding to Paxillin LD1 Motif Regulates ILK Localization to Focal Adhesions

2001 • 208 citations

Characterization of the TGF beta 1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence.

1994 • 207 citations

Actopaxin, a New Focal Adhesion Protein That Binds Paxillin Ld Motifs and Actin and Regulates Cell Adhesion

2000 • 196 citations

Direct Association of Protein-tyrosine Phosphatase PTP-PEST with Paxillin

1998 • 176 citations

Identification of a New Pyk2 Target Protein with Arf-GAP Activity

1999 • 171 citations

Mechanosensitive tyrosine phosphorylation of paxillin and focal adhesion kinase in tracheal smooth muscle

1999 • 164 citations

Lipopolysaccharide Induces Actin Reorganization and Tyrosine Phosphorylation of Pyk2 and Paxillin in Monocytes and Macrophages

2000 • 155 citations

Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin

1999 • 153 citations

Rho stimulates tyrosine phosphorylation of focal adhesion kinase, p130 and paxillin

1996 • 152 citations

Characterisation of the paxillin-binding site and the C-terminal focal adhesion targeting sequence in vinculin

1994 • 151 citations

Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages

1999 • 149 citations

ARF1 Mediates Paxillin Recruitment to Focal Adhesions and Potentiates Rho-stimulated Stress Fiber Formation in Intact and Permeabilized Swiss 3T3 Fibroblasts

1998 • 143 citations

The Role of Focal Adhesion Kinase Binding in the Regulation of Tyrosine Phosphorylation of Paxillin

1999 • 143 citations

The Related Adhesion Focal Tyrosine Kinase Forms a Complex with Paxillin in Hematopoietic Cells

1996 • 142 citations

Physiological signals and oncogenesis mediated through Crk family adapter proteins

1998 • 139 citations

Differential Regulation of Pyk2 and Focal Adhesion Kinase (FAK)

1998 • 137 citations

Serine and Threonine Phosphorylation of the Paxillin LIM Domains Regulates Paxillin Focal Adhesion Localization and Cell Adhesion to Fibronectin

1998 • 136 citations

CRKL Links p210BCR/ABL with Paxillin in Chronic Myelogenous Leukemia Cells

1995 • 136 citations

Interaction of the τ2 Transcriptional Activation Domain of Glucocorticoid Receptor with a Novel Steroid Receptor Coactivator, Hic-5, Which Localizes to Both Focal Adhesions and the Nuclear Matrix

2000 • 134 citations

Association of Bovine Papillomavirus Type 1 E6 oncoprotein with the focal adhesion protein paxillin through a conserved protein interaction motif

1998 • 132 citations

Integrins Regulate the Association and Phosphorylation of Paxillin by c-Abl

1998 • 123 citations

Dissociation of FAK/p130CAS/c-Src Complex during Mitosis: Role of Mitosis-specific Serine Phosphorylation of FAK

1999 • 121 citations

Paxillin Is Tyrosine-phosphorylated by and Preferentially Associates with the Calcium-dependent Tyrosine Kinase in Rat Liver Epithelial Cells

1997 • 118 citations

Association of beta 1 integrin with focal adhesion kinase and paxillin in differentiating Schwann cells.

2000 • 114 citations

Sphingosine induces p125FAK and paxillin tyrosine phosphorylation, actin stress fiber formation, and focal contact assembly in Swiss 3T3 cells.

1994 • 113 citations

Differential Effects of Platelet-derived Growth Factor BB on p125 Focal Adhesion Kinase and Paxillin Tyrosine Phosphorylation and on Cell Migration in Rabbit Aortic Vascular Smooth Muscle Cells and Swiss 3T3 Fibroblasts

1995 • 113 citations

Differential Signaling by the Focal Adhesion Kinase and Cell Adhesion Kinase β

1997 • 113 citations

Paxillin LD motifs may define a new family of protein recognition domains

1998 • 112 citations

Adhesion of fibroblasts to fibronectin stimulates both serine and tyrosine phosphorylation of paxillin

1997 • 112 citations

Overexpressed Csk Tyrosine Kinase Is Localized in Focal Adhesions, Causes Reorganization of α_vβ₅ Integrin, and Interferes with Hela Cell Spreading

1995 • 112 citations

Gα12 and Gα13 Stimulate Rho-dependent Tyrosine Phosphorylation of Focal Adhesion Kinase, Paxillin, and p130 Crk-associated Substrate

1998 • 110 citations

Integrin αvβ5-dependent Serine Phosphorylation of Paxillin in Cultured Human Macrophages Adherent to Vitronectin

1996 • 110 citations

A New Paxillin-binding Protein, PAG3/Papα/KIAA0400, Bearing an ADP-Ribosylation Factor GTPase-activating Protein Activity, Is Involved in Paxillin Recruitment to Focal Adhesions and Cell Migration

2000 • 108 citations

Angiotensin II Induces Migration and Pyk2/Paxillin Phosphorylation of Human Monocytes

2001 • 103 citations

Tyrosine Phosphorylation of Paxillin α Is Involved in Temporospatial Regulation of Paxillin-containing Focal Adhesion Formation and F-actin Organization in Motile Cells

2000 • 103 citations

Beta 2 integrin-dependent tyrosine phosphorylation of paxillin in human neutrophils treated with tumor necrosis factor.

1994 • 103 citations

Angiotensin II stimulation of rapid paxillin tyrosine phosphorylation correlates with the formation of focal adhesions in rat aortic smooth muscle cells

1995 • 97 citations

Tyrosine Phosphorylation of the Related Adhesion Focal Tyrosine Kinase in Megakaryocytes upon Stem Cell Factor and Phorbol Myristate Acetate Stimulation and Its Association with Paxillin

1997 • 96 citations

Association of β1 Integrin with Focal Adhesion Kinase and Paxillin in Differentiating Schwann Cells

2000 • 95 citations

Angiotensin II Stimulates Tyrosine Phosphorylation of the Focal Adhesion-associated Protein Paxillin in Aortic Smooth Muscle Cells

1995 • 94 citations

Leupaxin Is a Novel LIM Domain Protein That Forms a Complex with PYK2

1998 • 92 citations

The Bovine Papillomavirus E6 Protein Binds to the LD Motif Repeats of Paxillin and Blocks Its Interaction with Vinculin and the Focal Adhesion Kinase

1997 • 91 citations

An ADP-Ribosylation Factor GTPase-activating Protein Git2-short/KIAA0148 Is Involved in Subcellular Localization of Paxillin and Actin Cytoskeletal Organization

2001 • 91 citations

Hic-5, a Paxillin Homologue, Binds to the Protein-tyrosine Phosphatase PEST (PTP-PEST) through Its LIM 3 Domain

1999 • 89 citations

Complement receptor 3 (CR3, Mac-1, integrin alpha M beta 2, CD11b/CD18) is required for tyrosine phosphorylation of paxillin in adherent and nonadherent neutrophils.

1994 • 89 citations

Paxillin α and Crk-associated substrate exert opposing effects on cell migration and contact inhibition of growth through tyrosine phosphorylation

2000 • 89 citations

Cloning and expression of PTP-PEST. A novel, human, nontransmembrane protein tyrosine phosphatase.

1993 • 87 citations

Intact LIM 3 and LIM 4 Domains of Paxillin Are Required for the Association to a Novel Polyproline Region (Pro 2) of Protein-Tyrosine Phosphatase-PEST

1999 • 85 citations

Targeting of PYK2 to Focal Adhesions as a Cellular Mechanism for Convergence between Integrins and G Protein-coupled Receptor Signaling Cascades

2000 • 84 citations

Growth Hormone Stimulates the Tyrosine Phosphorylation and Association of p125 Focal Adhesion Kinase (FAK) with JAK2

1998 • 81 citations

Paxillin Binding to a Conserved Sequence Motif in the α4 Integrin Cytoplasmic Domain

2000 • 79 citations

Rho-dependent and -independent tyrosine phosphorylation of focal adhesion kinase, paxillin and p130Cas mediated by Ret kinase

1999 • 78 citations

Protein Tyrosine Phosphatase φ Regulates Paxillin Tyrosine Phosphorylation and Mediates Colony-Stimulating Factor 1-Induced Morphological Changes in Macrophages

2001 • 73 citations

The multiple endocrine neoplasia type 2B point mutation switches the specificity of the Ret tyrosine kinase towards cellular substrates that are susceptible to interact with Crk and Nck

1997 • 73 citations

Identification and Characterization of a High-Affinity Interaction Between v-Crk and Tyrosine-Phosphorylated Paxillin in CT10-Transformed Fibroblasts

1993 • 71 citations

The Noncatalytic Domain of Protein-tyrosine Phosphatase-PEST Targets Paxillin for Dephosphorylation in Vivo

2000 • 71 citations

Involvement of Focal Adhesion Kinase in Inhibition of Motility of Human Breast Cancer Cells by Sphingosine 1-Phosphate

1999 • 70 citations

Murine protein tyrosine phosphatase-PEST, a stable cytosolic protein tyrosine phosphatase

1995 • 70 citations

Serine phosphorylation of paxillin by heregulin-β1: role of p38 mitogen activated protein kinase

1999 • 66 citations

Paxillin Phosphorylation and Association with Lck and Pyk2 in Anti-CD3- or Anti-CD45-stimulated T Cells

1998 • 65 citations

Paxillin Binding Is Not the Sole Determinant of Focal Adhesion Localization or Dominant-Negative Activity of Focal Adhesion Kinase/Focal Adhesion Kinase-related Nonkinase

2000 • 63 citations

Monocyte Cells and Cancer Cells Express Novel Paxillin Isoforms with Different Binding Properties to Focal Adhesion Proteins

1997 • 60 citations

Interaction of Paxillin with p21-activated Kinase (PAK)

2001 • 59 citations

Phosphorylation of Paxillin via the ERK Mitogen-activated Protein Kinase Cascade in EL4 Thymoma Cells

2000 • 59 citations

Recruitment of the LIM protein hic-5 to focal contacts of human platelets

1998 • 54 citations

Hypoxia Induces Activation and Subcellular Translocation of Focal Adhesion Kinase (p125FAK) in Cultured Rat Cardiac Myocytes

1999 • 52 citations

Expression of DFak56, a Drosophila homolog of vertebrate focal adhesion kinase, supports a role in cell migration in vivo

1999 • 51 citations

The LIM domains of hic-5 protein recognize specific DNA fragments in a zinc-dependent manner in vitro

1998 • 49 citations

Cytoskeleton-dependent Tyrosine Phosphorylation of the p130Cas Family Member HEF1 Downstream of the G Protein-coupled Calcitonin Receptor

1999 • 49 citations

Paxillin Isoforms in Mouse

1998 • 48 citations

DFak56 Is a Novel Drosophila melanogaster Focal Adhesion Kinase

1999 • 47 citations

The aggregation of the high affinity IgE receptor induces tyrosine phosphorylation of paxillin, a focal adhesion protein.

1994 • 43 citations

Regulation of Neutrophil Adhesion by Pituitary Growth Hormone Accompanies Tyrosine Phosphorylation of Jak2, p125FAK, and Paxillin

2000 • 40 citations

Phosphorylation of Hic‐5 at tyrosine 60 by CAKβ and Fyn

2000 • 36 citations

Cloning and Characterization of Dfak56, a Homolog of Focal Adhesion Kinase, in Drosophila melanogaster

1999 • 35 citations

Specific decrease in the level of Hic-5, a focal adhesion protein, during immortalization of mouse embryonic fibroblasts, and its association with focal adhesion kinase

2000 • 35 citations

Identification of a Second Transforming Function in Bovine Papillomavirus Type 1 E6 and the Role of E6 Interactions with Paxillin, E6BP, and E6AP

2000 • 35 citations

Adenovirus-mediated Overexpression of C-terminal Src Kinase (Csk) in Type I Astrocytes Interferes with Cell Spreading and Attachment to Fibronectin

1999 • 33 citations

Beta2 integrins are not required for tyrosine phosphorylation of paxillin in human neutrophils.

1997 • 28 citations

Rapid impact of ?-amyloid on Paxillin in a neural cell line

1997 • 25 citations

The cloning, genomic organization and expression of the focal contact protein paxillin in Drosophila

2001 • 21 citations

Nerve growth factor stimulates tyrosine phosphorylation of paxillin in PC12h cells

1995 • 18 citations

The Csk Homologous Kinase, Chk, Binds Tyrosine Phosphorylated Paxillin in Human Blastic T Cells

1999 • 15 citations