Prenylation-dependent Association of Ki-Ras with Microtubules

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

PROTEIN PRENYLATION: Molecular Mechanisms and Functional Consequences

1996 • 1,977 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

1990 • 1,049 citations

p21ras is modified by a farnesyl isoprenoid.

1989 • 847 citations

The discovery and development of HMG-CoA reductase inhibitors.

1992 • 829 citations

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

1990 • 815 citations

Protein Lipidation in Cell Signaling

1995 • 771 citations

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity.

1992 • 542 citations

Distinct populations of microtubules: Tyrosinated and nontyrosinated alpha tubulin are distributed differently in vivo

1984 • 532 citations

Direct Demonstration of Geranylgeranylation and Farnesylation of Ki-Ras in Vivo

1997 • 361 citations

Protein Prenylation: a Mediator of Protein-Protein Interactions

1993 • 346 citations

The clinical pharmacology and use of antimicrotubule agents in cancer chemotherapeutics

1991 • 313 citations

Methylation and proteolysis are essential for efficient membrane binding of prenylated p21K-ras(B).

1991 • 291 citations

Polylysine and CVIM Sequences of K-RasB Dictate Specificity of Prenylation and Confer Resistance to Benzodiazepine Peptidomimetic in Vitro

1995 • 285 citations

Growth site localization of Rho1 small GTP-binding protein and its involvement in bud formation in Saccharomyces cerevisiae.

1994 • 242 citations

Rat Brain Microtubule Protein: Purification and Determination of Covalently Bound Phosphate and Carbohydrate

1972 • 229 citations

A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity.

1991 • 221 citations

Spatial dynamics of GFP-tagged proteins investigated by local fluorescence enhancement

1996 • 195 citations

The kinetics of microtubule assembly. Evidence for a two-stage nucleation mechanism.

1984 • 179 citations

Detection of 23-27 kDa GTP-binding proteins in platelets and other cells

1987 • 166 citations

Enzymatic modification of proteins with a geranylgeranyl isoprenoid.

1991 • 164 citations

Mammalian protein geranylgeranyltransferase. Subunit composition and metal requirements.

1992 • 157 citations

Identification of microtubule-associated proteins in the centrosome, spindle, and kinetochore of the early Drosophila embryo.

1989 • 151 citations

Identification of a C-terminal protein carboxyl methyltransferase in rat liver membranes utilizing a synthetic farnesyl cysteine-containing peptide substrate.

1990 • 150 citations

Methylation and demethylation reactions of guanine nucleotide-binding proteins of retinal rod outer segments.

1991 • 149 citations

The Ras-related GTPase Rac1 Binds Tubulin

1996 • 135 citations

Isoprenoid modification and plasma membrane association: critical factors for ras oncogenicity.

1991 • 126 citations

PxF, a prenylated protein of peroxisomes.

1994 • 107 citations

Yeast proteins associated with microtubules in vitro and in vivo.

1992 • 95 citations

Endoproteolytic processing of a farnesylated peptide in vitro.

1992 • 84 citations

Expression of specific high capacity mevalonate transport in a Chinese hamster cell variant.

1987 • 71 citations

A study of the Influence of mevalonic acid and its metabolites on the morphology of swiss 3T3 cells.

1982 • 70 citations

Enhanced interaction between tubulin and microtubule‐associated protein 2 via inhibition of MAP kinase and CDC2 kinase by paclitaxel

1995 • 54 citations

Mevalonate controls cytoskeleton organization and cell morphology in thyroid epithelial cells

1993 • 52 citations

Taxol induces tyrosine phosphorylation of SHC and its association with GRB2 in murine raw 264.7 cells

1997 • 50 citations

Microsomal membranes contain a high affinity binding site for prenylated peptides

1993 • 42 citations

Association of the low molecular weight GTP-binding protein rap2B with the cytoskeleton during platelet aggregation.

1993 • 34 citations

Structural characterization of prenyl groups attached to proteins

1990 • 33 citations

Molecular mechanisms in the antiproliferative action of taxol and tiazofurin.

1996 • 33 citations

A prenylated protein-specific endoprotease in rat liver microsomes that produces a carboxyl-terminal tripeptide

1993 • 32 citations

Incorporation of Rap 1b into the platelet cytoskeleton is dependent on thrombin activation and extracellular calcium.

1994 • 28 citations

Role of the microtubular system in morphological organization of normal and oncogene-transfected epithelial cells.

1994 • 26 citations

[2] Isolation of protein prenyltransferases from bovine brain and baculovirus expression system

1995 • 25 citations

Microtubules and tubulin sheet polymers elongate from isolated axonemes in vitro as observed by negative-stain electron microscopy

1991 • 7 citations

Effect of cAMP on the association of small GTP-binding proteins with the cytoskeleton of human platelets

1994 • 5 citations

[14] Prenylated peptides in identification of specific binding proteins

1995 • 3 citations