K-ras is an essential gene in the mouse with partial functional overlap with N-ras

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells¹

2010 • 4,125 citations

ras GENES

1987 • 3,818 citations

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells

1961 • 3,579 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Simplified mammalian DNA isolation procedure

1991 • 1,508 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

1990 • 1,049 citations

Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL

1995 • 961 citations

MAPKs: new JNK expands the group

1994 • 949 citations

Teratocarcinomas and embryonic stem cells : a practical approach

1987 • 878 citations

Small GTP-Binding Proteins and the Regulation of the Actin Cytoskeleton

1994 • 822 citations

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

1990 • 815 citations

The ras gene family and human carcinogenesis

1988 • 786 citations

The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes

1981 • 736 citations

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens

1994 • 617 citations

Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations

1983 • 553 citations

Differential expression of cellular oncogenes during pre- and postnatal development of the mouse

1982 • 540 citations

The ins and outs of Raf kinases

1994 • 537 citations

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

1995 • 533 citations

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

1994 • 523 citations

A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.

1991 • 477 citations

Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins

1984 • 471 citations

Genetic analysis of yeast RAS1 and RAS2 genes

1984 • 460 citations

Transgenesis by means of blastocyst-derived embryonic stem cell lines.

1986 • 432 citations

Production of homozygous mutant ES cells with a single targeting construct.

1992 • 418 citations

The Ras signal transduction pathway

1994 • 345 citations

Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system.

1996 • 325 citations

Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences.

1994 • 289 citations

Polylysine and CVIM Sequences of K-RasB Dictate Specificity of Prenylation and Confer Resistance to Benzodiazepine Peptidomimetic in Vitro

1995 • 285 citations

Role of Protein Modification Reactions in Programming Interactions Between Ras-Related GTPases and Cell Membranes

1994 • 279 citations

Mouse embryonic hematopoiesis

1995 • 266 citations

Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells.

1990 • 242 citations

The murine N-ras gene is not essential for growth and development.

1995 • 236 citations

The Ras signaling pathway in Drosophila

1995 • 226 citations

Differential expression of the ras gene family in mice.

1987 • 222 citations

Expression of ras proto-oncogene proteins in normal human tissues.

1987 • 216 citations

Mutational analysis of a ras catalytic domain.

1986 • 205 citations

A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21.

1991 • 202 citations

Disruption of Oncogenic K-Ras4B Processing and Signaling by a Potent Geranylgeranyltransferase I Inhibitor

1995 • 176 citations

Production and analysis of chimeric mice

1987 • 175 citations

Properties of the earliest clonogenic hemopoietic precursors to appear in the developing murine yolk sac.

1986 • 174 citations

Transcription of c-onc Genes c-ras^Ki and c-fms During Mouse Development

1983 • 173 citations

Hematopoiesis: how does it happen?

1995 • 169 citations

Expression of p21ras in normal and malignant human tissues: lack of association with proliferation and malignancy.

1987 • 159 citations

Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells.

1996 • 152 citations

Production of Homozygous Mutant ES Cells with a Single Targeting Construct

1992 • 140 citations

Protein prenylation: key to ras function and cancer intervention?

1992 • 134 citations

The significance of DNA and protein adducts in human biomonitoring studies

1988 • 126 citations

Transcription of c-onc genes c-rasKi and c-fms during mouse development.

1983 • 117 citations

Structure and expression of amplified cKi-ras gene sequences in Y1 mouse adrenal tumor cells.

1985 • 77 citations

Comparison of kinetic properties between two mammalian ras p21 GDP/GTP exchange proteins, ras guanine nucleotide-releasing factor and smg GDP dissociation stimulation.

1993 • 54 citations

Small GTP-Binding Proteins and the Regulation of the Actin Cytoskeleton

1994 • 53 citations

Plugging it in: signaling circuits and the yeast cell cycle

1996 • 50 citations

Differential Expression of the ras Gene Family in Mice

1987 • 44 citations

Effect of a Dominant Inhibitory Ha-ras Mutation on Mitogenic Signal Transduction in NIH 3T3 Cells

1990 • 42 citations

Recent advances in understanding signal transduction pathways in worms and flies

1996 • 37 citations

Mutational Analysis of a ras Catalytic Domain

1986 • 36 citations

The Ras/Raf signaling pathway is required for progression of mouse embryos through the two-cell stage.

1994 • 27 citations

Anti-Ras drugs come of age

1993 • 26 citations

Translocation of Ki-ras P21 between Membrane and Cytoplasm by smg GDS

1993 • 23 citations

Different functions of Smg GDP dissociation stimulator and mammalian counterpart of yeast Cdc25.

1994 • 12 citations

The Ras/Raf Signaling Pathway Is Required for Progression of Mouse Embryos Through the Two-Cell Stage

1994 • 8 citations

Role of Protein Lipidation Reactions in Programming Interactions Between Ras-Related GTPases and Cell Membranes

1994 • 5 citations