THE CROONIAN LECTURE 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Principles of CDK regulation

1995 • 3,267 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1997 • 2,746 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification.

1995 • 2,534 citations

Protein modules and signalling networks

1995 • 2,447 citations

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

1980 • 2,387 citations

Fusion of a Kinase Gene, ALK , to a Nucleolar Protein Gene, NPM , in Non-Hodgkin's Lymphoma

1994 • 2,375 citations

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification ¹

1995 • 2,199 citations

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1997 • 2,063 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

1995 • 1,808 citations

Tyrosine Kinase Inhibition: An Approach to Drug Development

1995 • 1,655 citations

Dimerization of cell surface receptors in signal transduction

1995 • 1,631 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

Chromosomal translocations in human cancer

1994 • 1,551 citations

The extracellular matrix as a cell survival factor.

1993 • 1,541 citations

The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

1993 • 1,438 citations

Three-dimensional structure of the tyrosine kinase c-Src

1997 • 1,402 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

1993 • 1,338 citations

Receptor Protein-Tyrosine Kinases and Their Signal Transduction Pathways

1994 • 1,309 citations

Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity

1995 • 1,287 citations

Cytokine receptor signalling

1995 • 1,242 citations

Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

1989 • 1,237 citations

Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

1994 • 1,211 citations

Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.

1980 • 1,184 citations

Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor

1982 • 1,138 citations

Structures of the Tyrosine Kinase Domain of Fibroblast Growth Factor Receptor in Complex with Inhibitors

1997 • 1,098 citations

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1994 • 1,071 citations

A thousand and one protein kinases

1987 • 1,066 citations

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1994 • 1,005 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

A Requirement for Flk1 in Primitive and Definitive Hematopoiesis and Vasculogenesis

1997 • 938 citations

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

1995 • 929 citations

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

1996 • 915 citations

The Receptor Tyrosine Kinase MuSK Is Required for Neuromuscular Junction Formation In Vivo

1996 • 881 citations

A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway

1997 • 861 citations

Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development

1995 • 800 citations

A Specific Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase

1994 • 800 citations

A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

1986 • 795 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

Vascular Dysmorphogenesis Caused by an Activating Mutation in the Receptor Tyrosine Kinase TIE2

1996 • 779 citations

Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus

1995 • 758 citations

Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: Crystal structures of the complexed and peptide-free forms

1993 • 758 citations

Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene

1993 • 756 citations

Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor

1982 • 675 citations

Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells

1981 • 669 citations

Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1993 • 658 citations

Agrin Acts via a MuSK Receptor Complex

1996 • 653 citations

Defective Lymphoid Development in Mice Lacking Jak3

1995 • 650 citations

Increase of the Catalytic Activity of Phospholipase C-γ1 by Tyrosine Phosphorylation

1990 • 650 citations

NMDA Channel Regulation by Channel-Associated Protein Tyrosine Kinase Src

1997 • 614 citations

Vinculin: A cytoskeletal target of the transforming protein of rous sarcoma virus

1981 • 591 citations

PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254

1991 • 583 citations

Neurotrophic factors and their receptors

1995 • 583 citations

Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene

1993 • 578 citations

Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

1996 • 572 citations

Tyr ⁵²⁷ Is Phosphorylated in pp60 ^{c- src} : Implications for Regulation

1986 • 567 citations

Purification of the major protein-tyrosine-phosphatases of human placenta.

1988 • 564 citations

Evidence that the phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virus

1980 • 560 citations

An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates

1979 • 540 citations

Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosine

1980 • 539 citations

Regulation of Phospholipase C-γ1 by Profilin and Tyrosine Phosphorylation

1991 • 532 citations

Avian sarcoma virus-transforming protein, pp60src shows protein kinase activity specific for tyrosine

1980 • 510 citations

ZAP-70 Deficiency in an Autosomal Recessive form of Severe Combined Immunodeficiency

1994 • 495 citations

A Noncatalytic Domain Conserved among Cytoplasmic Protein-Tyrosine Kinases Modifies the Kinase Function and Transforming Activity of Fujinami Sarcoma Virus P130^gag-fps

1986 • 478 citations

The protein kinases of budding yeast: six score and more

1997 • 473 citations

Signaling through focal adhesion kinase

1997 • 468 citations

SH2/SH3 signaling proteins

1994 • 457 citations

Reversible tyrosine phosphorylation of cdc2: Dephosphorylation accompanies activation during entry into mitosis

1989 • 453 citations

Evidence for In Vivo Phosphorylation of the Grb2 SH2-Domain Binding Site on Focal Adhesion Kinase by Src-Family Protein-Tyrosine Kinases

1996 • 450 citations

Changes in protein phosphorylation in Rous sarcoma virus-transformed chicken embryo cells.

1981 • 440 citations

Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation.

1985 • 439 citations

Fibronectin-Stimulated Signaling from a Focal Adhesion Kinase–c-Src Complex: Involvement of the Grb2, p130^cas, and Nck Adaptor Proteins

1997 • 432 citations

Mitogenic Signaling via G Protein-Coupled Receptors

1996 • 425 citations

Identification of a cellular protein substrate phosphorylated by the avian sarcoma virus-transforming gene product

1980 • 420 citations

The carbonic anhydrase domain of receptor tyrosine phosphatase β is a functional ligand for the axonal cell recognition molecule contactin

1995 • 397 citations

Allosteric regulation of the epidermal growth factor receptor kinase.

1986 • 381 citations

Focal Adhesion Kinase Overexpression Enhances Ras-dependent Integrin Signaling to ERK2/Mitogen-activated Protein Kinase through Interactions with and Activation of c-Src

1997 • 380 citations

The PTPase YopH inhibits uptake ofYersinia, tyrosine phosphorylation of p130^Casand FAK, and the associated accumulation of these proteins in peripheral focal adhesions

1997 • 373 citations

p62 : A Constitutively Tyrosine-Phosphorylated, GAP-Associated Protein in Chronic Myelogenous Leukemia Progenitor Cells

1997 • 371 citations

Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteins

1982 • 366 citations

Identification of p130Cas as a substrate of Yersinia YopH (Yop51), a bacterial protein tyrosine phosphatase that translocates into mammalian cells and targets focal adhesions

1997 • 366 citations

Identification of the Abl- and rasGAP-Associated 62 kDa Protein as a Docking Protein, Dok

1997 • 350 citations

The coordinated action of protein tyrosine phosphatases and kinases in cell signaling

1994 • 342 citations

Transformation by Rous sarcoma virus: A cellular substrate for transformation-specific protein phosphorylation contains phosphotyrosine

1980 • 328 citations

Structural basis for inhibition of receptor protein-tyrosine phosphatase-α by dimerization

1996 • 324 citations

Lilly Lecture: Molecular Mechanisms of Insulin Resistance: Lessons From Patients With Mutations in the Insulin-Receptor Gene

1992 • 319 citations

FGFR activation in skeletal disorders: Too much of a good thing

1997 • 319 citations

A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps.

1986 • 317 citations

Structure of the IRS-1 PTB Domain Bound to the Juxtamembrane Region of the Insulin Receptor

1996 • 314 citations

Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo.

1995 • 313 citations

HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator

1995 • 309 citations

Tyrosine kinase-dependent suppression of a potassium channel by the G protein-coupled m1 muscarinic acetylcholine receptor

1993 • 304 citations

Regulation of STAT‐dependent pathways by growth factors and cytokines

1996 • 297 citations

Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinases

1995 • 279 citations

A tail of two src's: Mutatis mutandis

1987 • 278 citations

Association of Src Tyrosine Kinase with a Human Potassium Channel Mediated by SH3 Domain

1996 • 266 citations

Dephosphorylation or antibody binding to the carboxy terminus stimulates pp60c-src.

1986 • 257 citations

Functional modulation of the nicotinic acetylcholine receptor by tyrosine phosphorylation

1988 • 250 citations

Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3′-kinase SH2 domains: a model for SH2-mediated receptor-target interactions.

1992 • 241 citations

SH2 Signaling in a Lower Eukaryote: A STAT Protein That Regulates Stalk Cell Differentiation in Dictyostelium

1997 • 230 citations

TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas.

1992 • 228 citations

Protein-tyrosine phosphatases.

1994 • 223 citations

PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation

1994 • 214 citations

Regulation of the Inositol 1,4,5-Trisphosphate Receptor by Tyrosine Phosphorylation

1996 • 212 citations

Tyrosine phosphorylation of mammalian RNA polymerase II carboxyl-terminal domain.

1993 • 206 citations

Phosphotyrosine-containing proteins isolated by affinity chromatography with antibodies to a synthetic hapten

1981 • 203 citations

A Novel Phosphotyrosine-binding Domain in the N-terminal Transforming Region of Cbl Interacts Directly and Selectively with ZAP-70 in T Cells

1996 • 201 citations

Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo.

1994 • 192 citations

Protein tyrosine phosphatases in signaling

1996 • 170 citations

Changes in Protein Phosphorylation in Rous Sarcoma Virus-Transformed Chicken Embryo Cells

1981 • 158 citations

Neither arginine nor histidine can carry out the function of lysine-295 in the ATP-binding site of p60src.

1986 • 156 citations

Regulatory recruitment of signalling molecules to the cell membrane by pleckstrinhomology domains

1997 • 155 citations

Vertebrate non‐receptor protein–tyrosine kinase families

1996 • 154 citations

Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts.

1993 • 136 citations

Targeting signal transduction for disease therapy

1996 • 127 citations

A mutation at the ATP-binding site of pp60v-src abolishes kinase activity, transformation, and tumorigenicity.

1985 • 126 citations

Eph receptor tyrosine kinases and their ligands in neural development

1996 • 125 citations

The receptor-like protein tyrosine phosphatase HPTP alpha has two active catalytic domains with distinct substrate specificities.

1991 • 121 citations

Mode-switching of a voltage-gated cation channel is mediated by a protein kinase A-regulated tyrosine phosphatase

1993 • 116 citations

Steel Factor and c-kit Protooncogene: Genetic Lessons in Signal Transduction

1994 • 116 citations

Evidence that the Abelson virus protein functions in vivo as a protein kinase that phosphorylates tyrosine.

1981 • 113 citations

The WW module competes with the SH3 domain?

1996 • 112 citations

4,5-Dianilinophthalimide: a protein-tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity.

1994 • 101 citations

The IRS-1 signaling system

1994 • 95 citations

Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domains.

1996 • 87 citations

Molecular cloning of a tyrosine kinase gene from the marine spongeGeodia cydonium: a new member belonging to the receptor tyrosine kinase class II family

1994 • 82 citations

Dephosphorylation or Antibody Binding to the Carboxy Terminus Stimulates pp60^c-src

1986 • 80 citations

Molecular Biology of Axon Guidance

1996 • 79 citations

The Receptor-like Protein-tyrosine Phosphatase, RPTPα, Is Phosphorylated by Protein Kinase C on Two Serines Close to the Inner Face of the Plasma Membrane

1995 • 78 citations

Developmentally regulated protein-tyrosine kinase genes in Dictyostelium discoideum.

1990 • 77 citations

Uncoupling of the proliferation and differentiation signals mediated by the murine macrophage colony-stimulating factor receptor expressed in myeloid FDC-P1 cells.

1995 • 76 citations

X‐linked agammaglobulinemia (XLA): A genetic tyrosine kinase (Btk) disease

1996 • 73 citations

Tyrosine phosphorylation and axon guidance: of mice and flies

1997 • 73 citations

Protein Tyrosine Phosphatases and the Control of Cellular Signaling Responses

1996 • 69 citations

The role of phosphotyrosine phosphatases in haematopoietic cell signal transduction

1997 • 67 citations

Identification of a Binding Site in c-Abl Tyrosine Kinase for the C-Terminal Repeated Domain of RNA Polymerase II

1996 • 65 citations

Tyrosine 706 and 807 phosphorylation site mutants in the murine colony-stimulating factor-1 receptor are unaffected in their ability to bind or phosphorylate phosphatidylinositol-3 kinase but show differential defects in their ability to induce early response gene transcription.

1991 • 56 citations

Identification of Tyrosine 706 in the Kinase Insert as the Major Colony-Stimulating Factor 1 (CSF-1)-Stimulated Autophosphorylation Site in the CSF-1 Receptor in a Murine Macrophage Cell Line

1990 • 53 citations

Requirement for Y706 of the murine (or Y708 of the human) CSF-1 receptor for STAT1 activation in response to CSF-1.

1996 • 52 citations

Structure and Expression of STK, a src-Related Gene in the Simple Metazoan Hydra attenuata

1989 • 51 citations

The Dictyostelium dual-specificity kinase splA is essential for spore differentiation

1996 • 45 citations

Prokaryotic expression cloning of a novel human tyrosine kinase.

1994 • 44 citations

Neither Arginine nor Histidine Can Carry Out the Function of Lysine-295 in the ATP-Binding Site of p60^src

1986 • 43 citations

Multiple src-related kinase genes, srk1-4, in the fresh water sponge Spongilla lacustris.

1992 • 41 citations

A Mutation at the ATP-Binding Site of pp60^v-src Abolishes Kinase Activity, Transformation, and Tumorigenicity

1985 • 39 citations

Structure and expression of STK, a src-related gene in the simple metazoan Hydra attenuata.

1989 • 39 citations

Identification of a gene encoding a novel protein-tyrosine kinase containing SH2 domains and ankyrin-like repeats.

1994 • 33 citations

Classification of tyrosine kinases from Dictyostelium discoideum with two distinct, complete or incomplete catalytic domains

1996 • 32 citations

Developmentally Regulated Protein-Tyrosine Kinase Genes in Dictyostelium discoideum

1990 • 29 citations

Identification of tyrosine 706 in the kinase insert as the major colony-stimulating factor 1 (CSF-1)-stimulated autophosphorylation site in the CSF-1 receptor in a murine macrophage cell line.

1990 • 25 citations

Tyrosine 706 and 807 Phosphorylation Site Mutants in the Murine Colony-Stimulating Factor-1 Receptor Are Unaffected in Their Ability To Bind or Phosphorylate Phosphatidylinositol-3 Kinase but Show Differential Defects in Their Ability To Induce Early Response Gene Transcription

1991 • 17 citations

Prokaryotic Expression Cloning of a Novel Human Tyrosine Kinase

1994 • 13 citations