Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domains.

Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase

1991 • 1,779 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

[11] Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates

1991 • 1,463 citations

Growth factor signaling by receptor tyrosine kinases

1992 • 1,450 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

Structural basis for the binding of proline-rich peptides to SH3 domains

1994 • 1,016 citations

Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane Enzymes

1991 • 973 citations

Two Binding Orientations for Peptides to the Src SH3 Domain: Development of a General Model for SH3-Ligand Interactions

1994 • 800 citations

Crystal Structure of Human Protein Tyrosine Phosphatase 1B

1994 • 747 citations

SH2 and SH3 domains

1993 • 697 citations

A versatilein vivoandin vitroeukaryotic expression vector for protein engineering

1988 • 686 citations

SH2-Containing Phosphotyrosine Phosphatase as a Target of Protein-Tyrosine Kinases

1993 • 666 citations

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1992 • 603 citations

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1993 • 587 citations

Structural Basis for Phosphotyrosine Peptide Recognition by Protein Tyrosine Phosphatase 1B

1995 • 575 citations

The GTPase dynamin binds to and is activated by a subset of SH3 domains

1993 • 557 citations

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos

1993 • 555 citations

Activation of a Phosphotyrosine Phosphatase by Tyrosine Phosphorylation

1993 • 554 citations

PROTEIN TYROSINE PHOSPHATASES

1993 • 532 citations

Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains

1994 • 519 citations

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

1994 • 477 citations

Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway

1994 • 458 citations

Structural diversity and evolution of human receptor-like protein tyrosine phosphatases.

1990 • 428 citations

The carbonic anhydrase domain of receptor tyrosine phosphatase β is a functional ligand for the axonal cell recognition molecule contactin

1995 • 397 citations

1002 Protein Phosphatases?

1992 • 330 citations

A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila.

1989 • 303 citations

Homophilic binding of PTP mu, a receptor-type protein tyrosine phosphatase, can mediate cell-cell aggregation

1993 • 268 citations

Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand.

1993 • 267 citations

Receptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiation.

1993 • 237 citations

Cell-cell adhesion mediated by a receptor-like protein tyrosine phosphatase

1993 • 227 citations

Receptor tyrosine phosphatase R-PTP-kappa mediates homophilic binding.

1994 • 224 citations

The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp.

1993 • 214 citations

Crystal Structure of the Mammalian Grb2 Adaptor

1995 • 202 citations

Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo.

1994 • 192 citations

Tyrosyl phosphorylation and growth factor receptor association of the human corkscrew homologue, SH-PTP2

1993 • 192 citations

Cloning and expression of a widely expressed receptor tyrosine phosphatase.

1990 • 180 citations

Interaction of Shc with Grb2 Regulates Association of Grb2 with mSOS

1995 • 174 citations

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase.

1994 • 172 citations

Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells.

1994 • 159 citations

Identification of an additional member of the protein-tyrosine-phosphatase family: evidence for alternative splicing in the tyrosine phosphatase domain.

1990 • 149 citations

PTP-PEST: a protein tyrosine phosphatase regulated by serine phosphorylation.

1994 • 135 citations

Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase.

1994 • 132 citations

Binding of the Grb2 SH2 domain to phosphotyrosine motifs does not change the affinity of its SH3 domains for Sos proline-rich motifs.

1994 • 126 citations

The receptor-like protein tyrosine phosphatase HPTP alpha has two active catalytic domains with distinct substrate specificities.

1991 • 121 citations

Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity.

1994 • 119 citations

Binding of Vav to Grb2 through dimerization of Src homology 3 domains.

1994 • 112 citations

Negative Regulation of CD45 Protein Tyrosine Phosphatase Activity by Ionomycin in T Cells

1991 • 108 citations

The Receptor-like Protein-tyrosine Phosphatase, RPTPα, Is Phosphorylated by Protein Kinase C on Two Serines Close to the Inner Face of the Plasma Membrane

1995 • 78 citations

Receptor tyrosine phosphatase R-PTP-alpha is tyrosine-phosphorylated and associated with the adaptor protein Grb2.

1994 • 77 citations

Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2.

1994 • 75 citations

Phosphorylation and identification of a major tyrosine phosphorylation site in protein tyrosine phosphatase 1C.

1994 • 72 citations

A complex of GRB2-dynamin binds to tyrosine-phosphorylated insulin receptor substrate-1 after insulin treatment.

1994 • 71 citations

Stimulation of receptor protein-tyrosine phosphatase alpha activity and phosphorylation by phorbol ester.

1995 • 65 citations

Association of Hematopoietic Cell Phosphatase with c-Kit After Stimulation with c-Kit Ligand

1993 • 60 citations

Multiple forms of the human tyrosine phosphatase RPTP alpha. Isozymes and differences in glycosylation.

1994 • 55 citations

Receptor tyrosine phosphatase R-PTP-κ mediates homophilic binding

1994 • 40 citations

Lck-Dependent Tyrosyl Phosphorylation of the Phosphotyrosine Phosphatase SH-PTP1 in Murine T Cells

1994 • 33 citations

Protein Tyrosine Phosphatases

1993 • 30 citations

Tyrosine Phosphorylation of CD45 Phosphotyrosine Phosphatase by p50^csk Kinase Creates A Binding Site for p56^lck Tyrosine Kinase and Activates the Phosphatase

1994 • 29 citations

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