Eph receptor tyrosine kinases and their ligands in neural development

Oncogenes and signal transduction

1991 • 2,816 citations

Homeobox genes and axial patterning

1992 • 2,688 citations

CHEMOAFFINITY IN THE ORDERLY GROWTH OF NERVE FIBER PATTERNS AND CONNECTIONS

1963 • 1,947 citations

Growth factor signaling by receptor tyrosine kinases

1992 • 1,450 citations

Receptor Protein-Tyrosine Kinases and Their Signal Transduction Pathways

1994 • 1,309 citations

In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases

1995 • 849 citations

Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map

1995 • 740 citations

Ligands for EPH-Related Receptor Tyrosine Kinases that Require Membrane Attachment or Clustering for Activity

1994 • 720 citations

Neurotrophin receptors: A window into neuronal differentiation

1992 • 704 citations

Recognition of position-specific properties of tectal cell membranes by retinal axons in vitro

1987 • 486 citations

Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain

1993 • 452 citations

A Novel Putative Tyrosine Kinase Receptor Encoded by the eph Gene

1987 • 430 citations

An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system

1991 • 427 citations

Avoidance of posterior tectal membranes by temporal retinal axons

1987 • 370 citations

Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin.

1990 • 369 citations

The cellular basis of segmentation in the developing hindbrain

1990 • 358 citations

Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases

1994 • 332 citations

Expression of truncated Sek-1 receptor tyrosine kinase disrupts the segmental restriction of gene expression in the Xenopus and zebrafish hindbrain

1995 • 315 citations

Inaccuracies in initial growth and arborization of chick retinotectal axons followed by course corrections and axon remodeling to develop topographic order

1989 • 273 citations

Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation

1995 • 261 citations

Biochemical characterization of a putative axonal guidance molecule of the chick visual system

1990 • 241 citations

B61 is a ligand for the ECK receptor protein-tyrosine kinase

1994 • 239 citations

cDNA Cloning and Characterization of eck, an Epithelial Cell Receptor Protein-Tyrosine Kinase in the eph/elk Family of Protein Kinases

1990 • 234 citations

A receptor protein tyrosine kinase implicated in the segmental patterning of the hindbrain and mesoderm

1992 • 226 citations

Axonal guidance in the chick visual system: Posterior tectal membanes induce collapse of growth cones from the temporal retina

1990 • 208 citations

Eph receptor tyrosine kinases, axon repulsion, and the development of topographic maps

1995 • 187 citations

Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis.

1994 • 174 citations

Hox Genes and Regionalization of the Nervous System

1994 • 172 citations

cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases.

1990 • 159 citations

A Novel Immediate-Early Response Gene of Endothelium Is Induced by Cytokines and Encodes a Secreted Protein

1990 • 159 citations

ELF-2, a New Member of the Eph Ligand Family, Is Segmentally Expressed in Mouse Embryos in the Region of the Hindbrain and Newly Forming Somites

1995 • 155 citations

Novel protein-tyrosine kinase cDNAs related to fps/fes and eph cloned using anti-phosphotyrosine antibody.

1988 • 151 citations

Membrane-bound LERK2 ligand can signal through three different Eph-related receptor tyrosine kinases.

1995 • 141 citations

Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors.

1994 • 141 citations

Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain

1994 • 135 citations

Spatially regulated expression of three receptor tyrosine kinase genes during gastrulation in the zebrafish

1994 • 132 citations

Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis.

1994 • 125 citations

Polarized Expression of the Receptor Protein Tyrosine Kinase Cek5 in the Developing Avian Visual System

1995 • 125 citations

Directional cues for growing axons forming the retinotectal projection

1987 • 117 citations

Five novel avian Eph-related tyrosine kinases are differentially expressed.

1993 • 112 citations

eph, the largest known family of putative growth factor receptors

1994 • 112 citations

Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines.

1992 • 110 citations

A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein.

1990 • 109 citations

The expression of the receptor-protein tyrosine kinase gene, eck, is highly restricted during early mouse development

1994 • 98 citations

How do retinal axons find their targets on the tectum?

1984 • 98 citations

Splice-site mutation of the p53 gene in a family with hereditary breast-ovarian cancer.

1994 • 91 citations

Ehk-1 and Ehk-2: two novel members of the Eph receptor-like tyrosine kinase family with distinctive structures and neuronal expression.

1993 • 84 citations

Characterization of elk, a brain-specific receptor tyrosine kinase.

1991 • 84 citations

Cell Signalling: Receptor orphans find a family

1995 • 82 citations

Topographic maps and molecular gradients

1993 • 79 citations

The Eck receptor tyrosine kinase is implicated in pattern formation during gastrulation, hindbrain segmentation and limb development.

1994 • 78 citations

Telling Axons Where to Grow: A Role for Eph Receptor Tyrosine Kinases in Guidance

1995 • 76 citations

The molecular basis of retinotectal topography

1994 • 76 citations

Identification of chicken embryo kinase 5, a developmentally regulated receptor-type tyrosine kinase of the Eph family.

1991 • 76 citations

Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily.

1994 • 74 citations

cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases.

1995 • 69 citations

Axonal guidance by an avoidance mechanism.

1990 • 68 citations

Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins.

1995 • 68 citations

Identification of alternatively spliced mRNAs encoding variants of MDK1, a novel receptor tyrosine kinase expressed in the murine nervous system.

1995 • 66 citations

Characterization of B61, the Ligand for the Eck Receptor Protein-Tyrosine Kinase

1995 • 65 citations

Embryo brain kinase: a novel gene of the eph/elk receptor tyrosine kinase family

1995 • 63 citations

Characterization of the expression of the Cek8 receptor-type tyrosine kinase during development and in tumor cell lines.

1994 • 62 citations

cDNA cloning and characterization of a ligand for the Cek5 receptor protein-tyrosine kinase.

1994 • 62 citations

Cek5, a membrane receptor-type tyrosine kinase, is in neurons of the embryonic and postnatal avian brain

1992 • 57 citations

Differential expressions of the eph family of receptor tyrosine kinase genes (sek, elk, eck) in the developing nervous system of the mouse

1995 • 52 citations

Pagliaccio, a member of the Eph family of receptor tyrosine kinase genes, has localized expression in a subset of neural crest and neural tissues in Xenopus laevis embryos

1994 • 51 citations

Mechanisms and molecules controlling the development of retinal maps.

1995 • 36 citations

eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases.

1991 • 35 citations

Expression and developmental regulation of Ehk-1, a neuronal Elk-like receptor tyrosine kinase in brain

1994 • 33 citations

Cek5, a Tyrosine Kinase of the Eph Subclass, Is Activated during Neural Retina Differentiation

1994 • 30 citations

Identification of a complete Cek7 receptor protein tyrosine kinase coding sequence and cDNAs of alternatively spliced transcripts

1994 • 29 citations

Molecular cloning and expression of rat and mouse B61 gene: implications on organogenesis.

1995 • 20 citations