A thousand and one protein kinases

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

The Molecular Genetics of Cancer

1987 • 1,729 citations

PROTEIN SERINE/THREONINE KINASES

1987 • 1,457 citations

An Adenosine 3′,5′-Monophosphate-dependant Protein Kinase from Rabbit Skeletal Muscle

1968 • 1,423 citations

Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

1987 • 1,153 citations

Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways

1986 • 1,044 citations

Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog

1987 • 1,004 citations

The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester Receptor

1986 • 878 citations

Regulation of brain Type II Ca2+/calmodulin-dependent protein kinase by autophosphorylation: A Ca2+-triggered molecular switch

1986 • 856 citations

A native 170,000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles.

1982 • 788 citations

C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity.

1984 • 715 citations

Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase

1987 • 703 citations

A Yeast Gene That Is Essential for Release from Glucose Repression Encodes a Protein Kinase

1986 • 688 citations

Cloning and expression of multiple protein kinase C cDNAs

1986 • 683 citations

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.

1986 • 650 citations

Tyr ⁵²⁷ Is Phosphorylated in pp60 ^{c- src} : Implications for Regulation

1986 • 567 citations

Covalent modification of the glnG product, NRI, by the glnL product, NRII, regulates the transcription of the glnALG operon in Escherichia coli.

1986 • 565 citations

PROTEIN KINASES IN THE BRAIN

1985 • 559 citations

Phosphorylation activates the insulin receptor tyrosine protein kinase.

1983 • 558 citations

The cell cycle control gene cdc2+ of fission yeast encodes a protein kinase potentially regulated by phosphorylation

1986 • 502 citations

Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene

1986 • 489 citations

Tissue-specific expression of three distinct types of rabbit protein kinase C

1987 • 469 citations

Two-component regulatory systems responsive to environmental stimuli share strongly conserved domains with the nitrogen assimilation regulatory genes ntrB and ntrC.

1986 • 464 citations

Sevenless , a Cell-Specific Homeotic Gene of Drosophila , Encodes a Putative Transmembrane Receptor with a Tyrosine Kinase Domain

1987 • 421 citations

Factors Affecting the Activity of Muscle Phosphorylase b Kinase

1959 • 418 citations

Neurobiology: Memory and molecular turnover

1984 • 377 citations

The role of protein phosphorylation in the hormonal control of enzyme activity

1985 • 377 citations

Protein kinase activity associated with the product of the yeast cell division cycle gene CDC28.

1985 • 370 citations

Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2+ and suc1+

1987 • 341 citations

The mitotic inducer nim1+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis

1987 • 334 citations

Neuronal pp60 ^{c- src} Contains a Six-Amino Acid Insertion Relative to Its Non-Neuronal Counterpart

1987 • 313 citations

Light-regulated binding of rhodopsin kinase and other proteins to cattle photoreceptor membranes

1978 • 313 citations

Alternative 5′ exons in c-abl mRNA

1986 • 290 citations

Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase.

1986 • 286 citations

Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells.

1987 • 278 citations

Dephosphorylation or antibody binding to the carboxy terminus stimulates pp60c-src.

1986 • 257 citations

Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin.

1987 • 253 citations

Characterization of Saccharomyces cerevisiae genes encoding subunits of cyclic AMP-dependent protein kinase.

1987 • 239 citations

The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck.

1987 • 236 citations

Self-phosphorylation enhances the protein-tyrosine kinase activity of the epidermal growth factor receptor.

1985 • 232 citations

Evidence that the avian sarcoma virus transforming gene product is a cyclic AMP-independent protein kinase.

1979 • 232 citations

Viral src gene products are related to the catalytic chain of mammalian cAMP-dependent protein kinase.

1982 • 225 citations

yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family.

1986 • 219 citations

Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor.

1984 • 219 citations

Two types of complementary DNAs of rat brain protein kinase C

1986 • 212 citations

Purification and characterization of a protein kinase from Xenopus eggs highly specific for ribosomal protein S6.

1986 • 207 citations

A cloned bovine cDNA encodes an alternate form of the catalytic subunit of cAMP-dependent protein kinase.

1986 • 206 citations

Nucleotide sequence and formation of the transforming gene of a mouse sarcoma virus

1981 • 203 citations

The Drosophila EGF receptor gene homolog: Conservation of both hormone binding and kinase domains

1985 • 202 citations

The nucleotide sequence and the tissue-specific expression of Drosophila c-src

1985 • 201 citations

Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family.

1987 • 191 citations

Nucleotide sequence of the yeast regulatory gene STE7 predicts a protein homologous to protein kinases.

1986 • 189 citations

Dual regulation of the yeast CDC28-p40 protein kinase complex: Cell cycle, pheromone, and nutrient limitation effects

1987 • 166 citations

Isolation of cDNA clones encoding protein kinase C: evidence for a protein kinase C-related gene family.

1987 • 156 citations

Protein Kinases in the Brain

1985 • 134 citations

Molecular characterization of cell cycle gene CDC7 from Saccharomyces cerevisiae.

1986 • 126 citations

Cloning of rat brain protein kinase C complementary DNA

1986 • 124 citations

Isolation of a Drosophila genomic sequence homologous to the kinase domain of the human insulin receptor and detection of the phosphorylated Drosophila receptor with an anti-peptide antibody.

1986 • 123 citations

Enzymatically inactive p60c-src mutant with altered ATP-binding site is fully phosphorylated in its carboxy-terminal regulatory region

1987 • 117 citations

6 Viral Oncogenes and Tyrosine Phosphorylation

1986 • 116 citations

Isolation and Oncogenic Potential of a Novel Human src-Like Gene

1986 • 113 citations

Drosophila melanogaster DNA clones homologous to vertebrate oncogenes: Evidence for a common ancestor to the src and abl cellular genes

1983 • 91 citations

A Novel Human Gene Closely Related to the abl Proto-Oncogene

1986 • 89 citations

Characterization of protein kinases forming acid-labile histone phosphates in Walker-256 carcinosarcoma cell nuclei

1974 • 89 citations

Cloning of a drosophila cDNA encoding a polypeptide similar to the human insulin receptor precursor

1986 • 73 citations

Isolation and oncogenic potential of a novel human src-like gene.

1986 • 69 citations

Stimulation of ribosomal protein S6 kinase activity by pp60v-src or by serum: dissociation from phorbol ester-stimulated activity.

1986 • 68 citations

Protein-Tyrosine Kinase Activity in Saccharomyces cerevisiae

1986 • 67 citations

A Drosophila genomic sequence with homology to human epidermal growth factor receptor

1985 • 66 citations

Isolation and nucleotide sequence of a Saccharomyces cerevisiae protein kinase gene suppressing the cell cycle start mutation cdc25.

1987 • 63 citations

Trends in oncogenes

1985 • 58 citations

Isolation of chicken cellular DNA sequences with homology to the region of viral oncogenes that encodes the tyrosine kinase domain.

1986 • 14 citations