Visualizing the Higher Order Folding of a Catalytic RNA Molecule

The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme

1983 • 2,604 citations

Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena

1982 • 2,241 citations

Mapping adenines, guanines, and pyrimidines in RNA

1977 • 1,391 citations

INTERMEDIATES IN THE FOLDING REACTIONS OF SMALL PROTEINS

1990 • 1,133 citations

Simple RNA enzymes with new and highly specific endoribonuclease activities

1988 • 1,118 citations

Specific Intermediates in the Folding Reactions of Small Proteins and the Mechanism of Protein Folding

1982 • 1,041 citations

A small catalytic oligoribonucleotide

1987 • 938 citations

SELF-SPLICING OF GROUP I INTRONS

1990 • 852 citations

Comparative and functional anatomy of group II catalytic introns — a review

1989 • 768 citations

Folding and association of proteins

1987 • 697 citations

The Chemistry of Self-Splicing RNA and RNA Enzymes

1987 • 523 citations

Hydroxyl radical "footprinting": high-resolution information about DNA-protein contacts and application to lambda repressor and Cro protein.

1986 • 518 citations

Comparison of fungal mitochondrial introns reveals extensive homologies in RNA secondary structure

1982 • 501 citations

The Intervening Sequence RNA of Tetrahymena Is an Enzyme

1986 • 498 citations

Cleavage of DNA with methidiumpropyl-EDTA-iron(II): reaction conditions and product analyses

1984 • 477 citations

Making ends meet: a model for RNA splicing in fungal mitochondria

1982 • 459 citations

Conserved sequences and structures of group I introns: building an active site for RNA catalysis — a review

1988 • 451 citations

Structural analysis of spermine and magnesium ion binding to yeast phenylalanine transfer RNA.

1978 • 377 citations

Defining the Inside and Outside of a Catalytic RNA Molecule

1989 • 368 citations

RNA catalytic properties of the minimum (-)sTRSV sequence

1989 • 360 citations

The guanosine binding site of the Tetrahymena ribozyme

1989 • 356 citations

A crystallographic study of metal-binding to yeast phenylalanine transfer RNA

1977 • 322 citations

[33] Hydroxyl radical footprinting: A high-resolution method for mapping protein-DNA contacts

1987 • 322 citations

The Tetrahymena ribozyme acts like an RNA restriction endonuclease

1986 • 285 citations

Human hepatitis delta virus RNA subfragments contain an autocleavage activity.

1989 • 284 citations

Structural conventions for group I introns

1987 • 280 citations

Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 1. Kinetic description of the reaction of an RNA substrate complementary to the active site

1990 • 280 citations

Iron(II) EDTA Used to Measure the Helical Twist Along Any DNA Molecule

1985 • 274 citations

Sequence-specific endoribonuclease activity of the Tetrahymena ribozyme: enhanced cleavage of certain oligonucleotide substrates that form mismatched ribozyme-substrate complexes

1988 • 251 citations

RNA-catalysed synthesis of complementary-strand RNA

1989 • 228 citations

RNA - ligand interactions:(I) magnesium binding sites in yeast tRNA^Phe

1977 • 221 citations

One binding site determines sequence specificity of Tetrahymena pre-rRNA self-splicing, trans-splicing, and RNA enzyme activity

1986 • 211 citations

Iron(II)-ethylenediaminetetraacetic acid catalyzed cleavage of RNA and DNA oligonucleotides: similar reactivity toward single- and double-stranded forms

1990 • 192 citations

Self-cleavage of RNA in the replication of small pathogens of plants and animals

1989 • 177 citations

Tertiary Structure in Transfer Ribonucleic Acids

1966 • 175 citations

Molecular genetics of group I introns: RNA structures and protein factors required for splicing — a review

1988 • 174 citations

Laser temperature-jump, spectroscopic, and thermodynamic study of salt effects on duplex formation by dGCATGC

1989 • 163 citations

Ribonuclease P: An Enzyme with a Catalytic RNA Subunit

1989 • 143 citations

Metal ion requirements for sequence-specific endoribonuclease activity of the Tetrahymena ribozyme

1989 • 139 citations

Splice-site selection by a self-splicing RNA of Tetrahymena

1986 • 134 citations

Direct measurement of oligonucleotide substrate binding to wild-type and mutant ribozymes from Tetrahymena.

1990 • 132 citations

DNA cleavage catalysed by the ribozyme from Tetrahymena

1990 • 130 citations

Reconstitution of a group I intron self-splicing reaction with an activator RNA.

1991 • 123 citations

Enzymatic activity of the conserved core of a group I self-splicing intron

1986 • 114 citations

Ribonuclease P: function and variation.

1990 • 104 citations

Genetic Studies of Protein Stability and Mechanisms of Folding

1988 • 102 citations

Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 2. Kinetic description of the reaction of an RNA substrate that forms a mismatch at the active site

1990 • 93 citations

Catalytic activity is retained in theTetrahymenagroup I intron despite removal of the large extension of element P5

1989 • 86 citations

Identification of a cytidine-specific ribonuclease from chicken liver.

1980 • 77 citations

Sequential folding of transfer RNA

1980 • 73 citations

Cation requirements of isoleucyl-tRNA synthetase from Escherichiacoli

1972 • 59 citations

Minimum secondary structure requirements for catalytic activity of a self-splicing group I intron

1990 • 57 citations

A conserved base pair within helix P4 of the Tetrahymena ribozyme helps to form the tertiary structure required for self-splicing.

1989 • 56 citations

An ultraviolet-inducible adenosine-adenosine cross-link reflects the catalytic structure of the Tetrahymena ribozyme

1990 • 55 citations

Alteration of substrate specificity for the endoribonucleolytic cleavage of RNA by the Tetrahymena ribozyme.

1989 • 54 citations

Structures Involved in Tetrahymena rRNA Self-splicing and RNA Enzyme Activity

1987 • 46 citations

Melting and chemical modification of a cyclized self-splicing group I intron: similarity of structures in 1 M sodium, in 10 mM magnesium and in the presence of substrate

1990 • 45 citations

Miniribozymes, small derivatives of the sunY intron, are catalytically active.

1989 • 39 citations

A nuclear magnetic resonance study of secondary and tertiary structure in yeast tRNAPhe

1977 • 37 citations

A new method for specific labelling of tRNA : Preliminary results on yeast tRNAPhe

1972 • 11 citations