Retroendocytosis of Insulin in Rat Adipocytes*

Metabolism of Isolated Fat Cells

1964 • 4,431 citations

Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes.

1983 • 1,586 citations

Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells.

1980 • 798 citations

Receptor-Mediated Transport of Insulin Across Endothelial Cells

1985 • 462 citations

Binding and degradation of 125I-insulin by rat hepatocytes.

1975 • 419 citations

Binding and endocytosis of cluster glycosides by rabbit hepatocytes. Evidence for a short-circuit pathway that does not lead to degradation.

1982 • 217 citations

Mannose-specific endocytosis receptor of alveolar macrophages: demonstration of two functionally distinct intracellular pools of receptor and their roles in receptor recycling.

1982 • 211 citations

Insulin Metabolism and Degradation*

1981 • 197 citations

The fate of insulin bound to adipocytes. Evidence for compartmentalization and processing.

1978 • 189 citations

Effects of lysosomotropic agents on insulin interactions with adipocytes. Evidence for a lysosomal pathway for insulin processing and degradation.

1979 • 185 citations

Binding and receptor-mediated degradation of insulin in adipocytes

1978 • 180 citations

Actions of insulin in fat cells. Effects of low temperature, uncouplers of oxidative phosphorylation, and respiratory inhibitors.

1977 • 175 citations

Internalization and degradation of fat cell-bound insulin. Separation and partial characterization of subcellular vesicles associated with iodoinsulin.

1979 • 161 citations

Kinetics of insulin receptor internalization and recycling in adipocytes. Shunting of receptors to a degradative pathway by inhibitors of recycling.

1985 • 140 citations

Surface binding and rates of internalization of 125I-insulin in adipocytes and IM-9 lymphocytes.

1982 • 116 citations

Dual pathways for the intracellular processing of insulin. Relationship between retroendocytosis of intact hormone and the recycling of insulin receptors.

1985 • 92 citations

Processing of Insulin by Bovine Endothelial Cells in Culture: Internalization Without Degradation

1984 • 90 citations

Initial site of insulin cleavage by insulin protease.

1979 • 84 citations

Quantitative ultrastructural analysis of receptor-mediated insulin uptake into adipocytes

1983 • 71 citations

Retro-endocytosis of low density lipoprotein by cultured bovine aortic smooth muscle cells

1981 • 67 citations

Recycling of the glucose transporter, the insulin receptor, and insulin in rat adipocytes. Effect of acidtropic agents.

1986 • 66 citations

Interactions Between Insulin and Its Receptors After the Initial Binding Event: Functional Heterogeneity and Relationships to Insulin Degradation

1979 • 66 citations

Insulin degradation by insulin target cells

1981 • 56 citations

RAPID TRANSPORT OF BIOLOGICALLY INTACT INSULIN THROUGH CULTURED ENDOTHELIAL CELLS

1984 • 43 citations

Insulin metabolism in rat hepatocytes. Evidence for generation of an insulin fragment missing a portion of the B chain involved in receptor binding.

1983 • 41 citations

High Performance Liquid Chromatographic Analysis of Insulin Degradation by Rat Skeletal Muscle Insulin Protease*

1986 • 39 citations

Binding, Internalization, and Degradation of Insulin in Vascular Endothelial Cells

1982 • 37 citations

Characterization of Insulin-Degrading Activity of Intact and Subcellular Components of Human Fibroblasts*

1985 • 33 citations

Early Detection of Degraded A14-125I-Insulin in Human Fibroblasts by the Use of High Performance Liquid Chromatography

1983 • 32 citations

Energy-Dependent Steps in Insulin-Hepatocyte Interaction*

1981 • 32 citations

[(125I]IodotyrosylB1]insulin. Semisynthesis, receptor binding, and cell-mediated degradation of a B chain-labeled insulin.

1981 • 27 citations

Evidence that Bacitracin Alters Intracellular Insulin Metabolism in Isolated Rat Hepatocytes

1985 • 27 citations

Insulin degradation by adipose tissue. Studies at several levels of cellular organization

1980 • 25 citations

Decreased Insulin Binding and Degradation Associated with Depressed Intracellular ATP Content

1980 • 19 citations

The effect of inhibitors of insulin processing on generation of insulin intermediate products from human fibroblast as detected by high performance liquid chromatography (HPLC)

1985 • 16 citations

Binding, internalization, and degradation of [125I]insulin by cultured bovine aortic endothelial cells: Effects of serotonin

1983 • 12 citations