Insulin Metabolism and Degradation*

Separation of leukocytes from blood and bone marrow

1968 • 2,787 citations

Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling.

1980 • 743 citations

Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells

1978 • 647 citations

Studies of Insulin, Growth Hormone and Prolactin Binding: Tissue Distribution, Species Variation and Characterization

1974 • 592 citations

Proinsulin, insulin, and C-peptide concentrations in human portal and peripheral blood.

1975 • 471 citations

A Model of the Kinetics of Insulin in Man

1974 • 464 citations

Acceleration of Reactivation of Reduced Bovine Pancreatic Ribonuclease by a Microsomal System from Rat Liver

1963 • 439 citations

Binding and degradation of 125I-insulin by rat hepatocytes.

1975 • 419 citations

Insulin-Receptor Interaction in the Obese-Hyperglycemic Mouse

1973 • 408 citations

Insulin Interactions with Liver Plasma Membranes

1972 • 396 citations

Receptor-binding region of insulin

1976 • 389 citations

Generation by Insulin of a Chemical Mediator That Controls Protein Phosphorylation and Dephosphorylation

1979 • 373 citations

Collection of insulin, EGF and α2-Macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization

1978 • 372 citations

GLUCOSE TOLERANCE AND DIABETES IN CHRONIC LIVER DISEASE

1967 • 363 citations

Epidermal growth factor: morphological demonstration of binding, internalization, and lysosomal association in human fibroblasts.

1978 • 358 citations

Localization of low density lipoprotein receptors on plasma membrane of normal human fibroblasts and their absence in cells from a familial hypercholesterolemia homozygote.

1976 • 323 citations

Characteristics of Human Erythrocyte Insulin Receptors

1978 • 292 citations

Metabolism of Proinsulin, Insulin, and C-Peptide in the Rat

1973 • 263 citations

Effects of Autoantibodies to the Insulin Receptor on Isolated Adipocytes

1977 • 244 citations

Binding and uptake of 125I-insulin into rat liver hepatocytes and endothelium. An in vivo radioautographic study.

1979 • 223 citations

Intracellular Translocation of Iodine-125-Labeled Insulin: Direct Demonstration in Isolated Hepatocytes

1978 • 220 citations

Effect of Renal Disease on Renal Uptake and Excretion of Insulin in Man

1970 • 202 citations

HYPERINSULINISM OF HEPATIC CIRRHOSIS: DIMINISHED DEGRADATION OR HYPERSECRETION?

1977 • 201 citations

Intracellular polypeptide hormone receptors. The demonstration of specific binding sites for insulin and human growth hormone in Golgi fractions isolated from the liver of female rats.

1978 • 196 citations

The fate of insulin bound to adipocytes. Evidence for compartmentalization and processing.

1978 • 189 citations

Effects of lysosomotropic agents on insulin interactions with adipocytes. Evidence for a lysosomal pathway for insulin processing and degradation.

1979 • 185 citations

Binding and receptor-mediated degradation of insulin in adipocytes

1978 • 180 citations

Down Regulation of Insulin Receptors in Primary Cultures of Adult Rat Hepatocytes in Monolayer*

1978 • 178 citations

Actions of insulin in fat cells. Effects of low temperature, uncouplers of oxidative phosphorylation, and respiratory inhibitors.

1977 • 175 citations

125I-insulin binding to cultured human lymphocytes. Initial localization and fate of hormone determined by quantitative electron microscopic autoradiography.

1978 • 171 citations

Cellular uptake and nuclear binding of insulin in human cultured lymphocytes: evidence for potential intracellular sites of insulin action.

1977 • 171 citations

The Renal Handling of Insulin*

1967 • 171 citations

Intracellular degradation of insulin stores by rat pancreatic islets in vitro. An alternative pathway for homeostasis of pancreatic insulin content.

1980 • 168 citations

Time course of insulin-receptor binding and insulin-induced lipogenesis in isolated rat fat cells.

1975 • 163 citations

Internalization and degradation of fat cell-bound insulin. Separation and partial characterization of subcellular vesicles associated with iodoinsulin.

1979 • 161 citations

The Metabolism of Proinsulin and Insulin by the Liver

1972 • 159 citations

Insulin Receptors in Human and Animal Placental Tissue

1974 • 155 citations

Binding of insulin to isolated nuclei.

1976 • 146 citations

Insulin binding and effects in isolated soleus muscle of lean and obese mice.

1978 • 145 citations

Retention and degradation of 125I-insulin by perfused livers from diabetic rats.

1976 • 135 citations

Effect of Intraduodenal Glucose Administration on Hepatic Extraction of Insulin in the Anesthetized Dog

1973 • 134 citations

Purification and characterization of cytoplasmic thioltransferase (glutathione:disulfide oxidoreductase) from rat liver

1978 • 133 citations

Proinsulin and C-peptide: A review

1977 • 130 citations

Portal and Peripheral Vein Immunoreactive Glucagon Concentrations After Arginine or Glucose Infusions

1974 • 128 citations

Glucose Intolerance and Insulin Resistance in Patients With Liver Disease

1969 • 126 citations

Effect of Chronic Sulfonylurea Therapy on Plasma Insulin and Proinsulin Levels

1972 • 119 citations

Purification of Insulin-Specific Protease by Affinity Chromatography

1972 • 119 citations

INSULIN BINDING TO RAT LIVER GOLGI FRACTIONS

1973 • 117 citations

Uptake of insulin by plasmalemma and Golgi subcellular fractions of rat liver.

1980 • 116 citations

Insulin Resistance Caused by Massive Degradation of Subcutaneous Insulin

1979 • 115 citations

Characterization of a Rat Liver Protease with Specificity for Insulin1

1972 • 108 citations

Hepatic glutathione-insulin transhydrogenase.

1962 • 108 citations

Metabolism of Insulin-I131 Studies in Isolated, Perfused Rat Liver and Hind-limb Preparations

1959 • 104 citations

How many distinct enzymes are responsible for the several cellular processes involving thiol:protein‐disulphide interchange?

1979 • 103 citations

The Effect of Zinc on Insulin Metabolism*

1978 • 102 citations

Insulin receptors in isolated rat hepatocytes. Reassessment of binding properties and observations of the inactivation of insulin at 37 degrees C.

1978 • 101 citations

Direct measurement of plasma proinsulin in normal and diabetic subjects

1972 • 101 citations

The Uptake and Inactivation of Native Insulin by Isolated Fat Cells

1968 • 99 citations

THE ROLE OF THE HUMAN PLACENTA IN THE TRANSFER AND METABOLISM OF INSULIN*

1962 • 98 citations

Purification and Characterization of a Protease with Specificity for Insulin from Rat Muscle

1971 • 97 citations

Absorption kinetics of subcutaneously injected insulin

1979 • 97 citations

Lysosomal Degradation of Receptor-bound 125I-labeled Insulin by Rat Adipocytes: Its Characterization and Dissociation from the Short-term Biologic Effects of Insulin

1980 • 96 citations

Cellular binding sites for insulin in rat liver

1975 • 94 citations

Mode of uptake and degradation of ¹²⁵I-labelled insulin by isolated hepatocytes and H4 hepatoma cells

1979 • 94 citations

Mode of Action of an Insulin-degrading Enzyme from Beef Liver

1962 • 93 citations

Clearance of Porcine Insulin, Proinsulin, and Connecting Peptide by the Isolated Rat Liver

1970 • 90 citations

Insulin and Glucagon Degradation by the Same Enzyme

1974 • 87 citations

Characterization of insulin-like actions of anti-insulin receptor antibodies. Effects on insulin binding, insulin degradation, and glycogen synthesis in isolated rat hepatocytes.

1980 • 86 citations

Initial site of insulin cleavage by insulin protease.

1979 • 84 citations

Cultured Hepatoma Cells as a Model System for Studying Insulin Processing and Biologic Responsiveness

1980 • 82 citations

Purification and characterization of a thiol:protein disulfide oxidoreductase from bovine liver.

1977 • 81 citations

Ultrastructural localization of insulin receptors on adipocytes.

1975 • 81 citations

Kinetic Analysis of Plasma Insulin Disappearance in Nonketotic Diabetic Patients and in Normal Subjects

1978 • 80 citations

Insulin Degradation by Hepatocytes in Primary Culture*

1981 • 78 citations

Studies on the Specificity and Mechanism of Action of Hepatic Glutathione-Insulin Transhydrogenase

1966 • 77 citations

CARBOHYDRATE METABOLISM IN PREGNANCY. I. THE METABOLISM OF INSULIN BY HUMAN PLACENTAL TISSUE*†

1960 • 77 citations

Insulin degradation. II. The widespread distribution of glutathione-insulin transhydrogenase in the tissues of the rat.

1972 • 75 citations

Intracellular binding sites for insulin are immunologically distinct from those on the plasma membrane

1977 • 75 citations

Effect of spontaneous portal-systemic shunting on plasma insulin and amino acid concentrations

1980 • 75 citations

Metabolism of Insulin and Glucagon

1973 • 75 citations

Characteristics of the Microvillus Brush Border of Human Placenta: Insulin Receptor Localization in Brush Border Membranes*

1978 • 74 citations

Hepatic Extraction of Exogenous Insulin and Glucagon in the Dog*

1978 • 74 citations

Metabolic Clearance of Insulin in Man

1972 • 72 citations

Insulin uptake in the renal proximal tubule

1973 • 72 citations

Derivation of a three compartment model describing disappearance of plasma insulin-131I in man

1969 • 71 citations

Kinetics of Native Insulin in Diabetic, Obese, and Aged Men

1979 • 71 citations

Removal of insulin by perfused rat liver: Effect of concentration

1975 • 71 citations

Biological potency and binding affinity of monoiodoinsulin with iodine in tyrosine A14 or tyrosine A19

1979 • 71 citations

Insulinase, insulinase-inhibitors, and diabetes mellitus.

1957 • 70 citations

Plasma Disappearance Rate of Injected Human Insulin in Juvenile Diabetic, Maturity-onset Diabetic and Nondiabetic Subjects

1969 • 70 citations

The natural occurrence of insulin receptors in groups on adipocyte plasma membranes as demonstrated with monomeric ferritin‐insulin

1977 • 69 citations

Degradation of Insulin and Proinsulin by Various Organ Homogenates of Rat

1972 • 68 citations

Biological Activity of Proinsulin and Related Polypeptides in the Fat Tissue

1973 • 68 citations

Functional relationships between insulin binding, action, and degradation. A reassessment.

1980 • 68 citations

Insulin and the Kidney

1975 • 67 citations

Insulin receptors of cultured human lymphocytes (IM-9). Lack of receptor-mediated degradation.

1980 • 67 citations

Comparison of the Effectiveness of Various Routes of Insulin Injection: Insulin Levels and Glucose Response in Normal Subjects

1976 • 67 citations

Degradation and Secretion of Insulin in Hepatic Cirrhosis

1978 • 67 citations

Degradation of Insulin by Isolated Rat Liver Cells

1975 • 66 citations

Interactions Between Insulin and Its Receptors After the Initial Binding Event: Functional Heterogeneity and Relationships to Insulin Degradation

1979 • 66 citations

Thiol-protein disulphide oxidoreductases. Assay of microsomal membrane-bound glutathione-insulin transhydrogenase and comparison with protein disulphide-isomerase

1976 • 65 citations

Direct measurement of proinsulin in human plasma by the use of an insulin-degrading enzyme

1971 • 63 citations

Physiological Processes and Dynamics in the Disposition of Small and Large Doses of Biologically Active and Inactive 131I-Insulins in the Rat

1967 • 63 citations

Insulin Binding to Adipocytes: Evidence for Functionally Distinct Receptors

1978 • 63 citations

The Endocytotic-Internalization Pathway of Insulin Metabolism: Relationship to Insulin Degradation and Activation of Glucose Transport*

1980 • 63 citations

Insulin binding sites on rat liver nuclear membranes: Biochemical and immunofluorescent studies

1978 • 63 citations

Effects of Spontaneous Portal-Systemic Shunting on Insulin Metabolism

1979 • 63 citations

Demonstration of the insulin receptor in vivo in rabbits and its possible role as a reservoir for the plasma hormone.

1978 • 62 citations

Formation of a receptor state from which insulin dissociates slowly in hepatic cells and plasma membranes.

1980 • 62 citations

Isolation from Rat Adipocytes of a Chemical Mediator for Insulin Activation of Pyruvate Dehydrogenase

1980 • 61 citations

Metabolism of Insulin and Glucagon. Breakdown of Radioiodinated Insulin and Glucagon in Rat Liver Cell Fractions

1971 • 60 citations

The kinetics of insulin metabolism in diabetes mellitus.

1973 • 60 citations

Insulin removal by isolated perfused rat liver

1976 • 59 citations

Polypeptide hormone binding sites in vivo: initial localization of 125I-labeled insulin to hepatocyte plasmalemma as visualized by electron microscope radioautography.

1977 • 59 citations

Reduction of Insulin by Extracts of Rat Liver

1959 • 59 citations

Insulin and placenta: Degradation and stabilization, binding to microvillous membrane receptors, and amino acid uptake

1979 • 59 citations

The inactivation of insulin by tissue extracts; the effect of fasting on the insulinase content of rat liver.

1949 • 57 citations

Insulin degradation I. Purification and properties of glutathione-insulin transhydrogenase of rat liver

1972 • 56 citations

Insulin Degradation by Liver Cell Membranes*

1979 • 53 citations

An anomaly of insulin removal in perfused livers of obese-hyperglycemic (ob/ob) mice.

1976 • 52 citations

Insulin and Glucagon-Receptor Interactions in the Genetically Obese Zucker Rat: Studies of Hormone Binding and Glucagon-Stimulated Cyclic AMP Levels in Isolated Hepatocytes¹

1977 • 52 citations

Comparison of 125I-Insulin Binding and Degradation to Isolated Rat Hepatocytes and Liver Membranes

1975 • 52 citations

Evidence that Somatomedin-C Is Degraded by the Kidney and Inhibits Insulin Degradation

1977 • 51 citations

Insulin degradation X. Identification of insulin degrading activity of rat liver plasma membrane as glutathione-insulin transhydrogenase

1973 • 51 citations

Insulin-degrading Activity of Plasma Membranes from Rat Skeletal Muscle: Its Isolation, Characterization, and Biologic Significance

1979 • 49 citations

Proteolytic degradation of insulin and glucagon

1975 • 48 citations

Hepatic insulin and glucagon extraction after their augmented secretion in dogs.

1978 • 47 citations

Insulin and glucagon degradation by the kidney I. Subcellular distribution under different assay conditions

1976 • 46 citations

Effect of acute uremia on insulin removal by the isolated perfused rat liver and muscle

1978 • 46 citations

Glucose tolerance, free fatty acid, and serum insulin responses in patients with cirrhosis

1969 • 45 citations

Insulin Metabolism in Chronic Uremia and in the Anephric State: Effect of the Dialytic Treatment1

1975 • 44 citations

Factors Influencing the Handling of Insulin by the Isolated Rat Kidney

1978 • 44 citations

Characterization, kinetics and comparative properties of thiol:protein disulfide oxidoreductase

1978 • 44 citations

The preparation of a semisynthetic tritiated insulin with a specific radioactivity of up to 20 Curies per millimole

1975 • 44 citations

Degradation of 131I-Insulins by Rat Liver

1972 • 44 citations

THE MODE OF INACTIVATION OF INSULIN BY RAT LIVER EXTRACTS

1955 • 42 citations

Different regulation of insulin receptors in intracellular (Golgi) and plasma membranes from livers of obese and lean mice.

1978 • 42 citations

Insulin Degradation by Isolated Fat Cells and their Subcellular Fractions

1975 • 42 citations

The identity of the insulin degrading thiol‐protein disulfide oxidoreductase (glutathione—insulin transhydrogenase) with the sulfhydryl‐disulfide interchange enzyme

1973 • 41 citations

Pharmacokinetics of Subcutaneously Injected Tritiated Insulin: Effects of Exercise

1979 • 41 citations

Characterization of the Insulin Receptor and Insulin-Degrading Activity from Human Lymphocytes by Quantitative Polyacrylamide Gel Electrophoresis*

1980 • 41 citations

Mobilization of subcutaneously injected tritiated insulin in rats: Effects of muscular exercise

1978 • 41 citations

Renal handling of endogenous glucagon in the dog: Comparison with insulin

1974 • 41 citations

Insulin degradation. XIV. Interaction of insulin analogs, glucagon, growth hormone, vasopressin, oxytocin, and scrambled forms of ribonuclease and lysozyme with glutathione-insulin transhydrogenase (thiol:protein-disulfide oxidoreductase). Dependence upon conformation

1975 • 41 citations

THE METABOLISM OF INSULIN.

1964 • 40 citations

Insulin and Glucagon Binding and Degradation by Kidney Cell Membranes*

1978 • 40 citations

Thiol-protein disulphide oxidoreductases. Differences between protein disulphide-isomerase and glutathione-insulin transhydrogenase activities in ox liver

1976 • 39 citations

Effect of prolonged uremia on insulin metabolism by isolated liver and muscle

1979 • 39 citations

Insulin Metabolizing Enzyme Activities in Human Placental Tissue

1973 • 39 citations

Insulin and glucagon degradation by the kidney II. Characterization of the mechanisms at neutral pH

1976 • 38 citations

Disappearance of Immunoreactive Insulin in Normal and Adult-onset Diabetic Subjects

1967 • 38 citations

Accelerated Insulin Degradation: An Alternate Mechanism for Insulin Resistance

1979 • 37 citations

Plasma insulin after diversion of portal and pancreatic venous blood to vena cava.

1967 • 37 citations

125I-insulin: kinetics of interaction with its receptors and rate of degradation in vivo

1980 • 36 citations

Insulin Degradation by Mononuclear Cells

1980 • 36 citations

Role of the Kidney in the Disposal of Radioiodinated and Nonradioiodinated Insulin in Dogs

1966 • 35 citations

Regulation of lipolysis and cyclic AMP synthesis through energy supply in isolated human fat cells

1977 • 35 citations

The Effect of Uremia Upon Glucose Metabolism

1970 • 35 citations

The Effect of Aprotinin on the Absorption of Subcutaneously Injected Regular Insulin in Normal Subjects

1980 • 34 citations

The Effect of Age on Insulin-degrading Activity in Rat Tissue

1979 • 34 citations

Increased Clearance and Degradation of [3H]Insulin in Streptozotocin Diabetic Rats

1981 • 33 citations

The effect of age on plasma proinsulin-like material after oral glucose.

1976 • 33 citations

Structure and Activity of Insulin, XII. Further Studies on Biologically Active Synthetic Fragments of the B-Chain

1973 • 32 citations

Insulin binding, insulin degradation and glucose metabolism in human monocytes

1979 • 32 citations

Insulin kinetics after portal and peripheral injection of [125I] insulin: II. Experiments in the intact dog

1976 • 32 citations

Energy-Dependent Steps in Insulin-Hepatocyte Interaction*

1981 • 32 citations

Time-course of insulin degradation in perifused isolated rat adipose cells.

1980 • 31 citations

Binding and Degradation of Semisynthetic Tritiated Insulin by IM-9 Cultured Human Lymphocytes

1980 • 31 citations

CARBOHYDRATE METABOLISM IN PREGNANCY: THE DEGRADATION OF INSULIN BY EXTRACTS OF MATERNAL AND FETAL STRUCTURES IN THE PREGNANT RAT¹

1959 • 31 citations

Cleavage of Bovine Insulin by Rat Adipose Tissue

1966 • 31 citations

Kinetic Modeling of Insulin Binding to Receptors and Degradation In Vivo in the Rabbit

1980 • 30 citations

THE RELATIVE SPECIFICITY OF THE INSULINASE ACTIVITY OF RAT LIVER EXTRACTS

1957 • 30 citations

Apparent Insulin Resistance due to Abnormal Enzymatic Insulin Degradation: A New Mechanism for Insulin Resistance

1980 • 30 citations

Insulin Disappearance after Intravenous Injection and its Effect on Blood Glucose in Diabetic and Non-Diabetic Children and Adults

1972 • 29 citations

Perturbation of Hormone Storage and Release Induced by Cyproheptadine in Rat Pancreatic Islets in Vitro*

1979 • 27 citations

Insulin degradation by lysosomal extracts from rat liver; model for a role of lysosomes in hormone degradation

1976 • 27 citations

Modulation of 125I-insulin degradation by receptors in liver plasma membranes

1977 • 26 citations

Metabolic disposition of [131I]iodoinsulin within the rat diaphragm☆

1970 • 26 citations

Insulin degradation by adipose tissue. Studies at several levels of cellular organization

1980 • 25 citations

Hepatic Balances of Glucose and Insulin in Response to Physiological Increments of Endogenous Insulin during Glucose Infusions in Dogs.

1975 • 25 citations

The renal uptake and excretion of insulin in the dog.

1969 • 25 citations

Insulin degradation

1974 • 24 citations

Binding and Degradation of Insulin by Isolated Renal Cortical Tubules*

1980 • 24 citations

Insulin Binding and Degradation by Muscles from Streptozotocin-diabetic Rats

1979 • 24 citations

Physical Characteristics of Insulin Receptors on Renal Cell Membranes

1978 • 24 citations

THE EFFECT OF PREGNANCY ON INSULIN HOMEOSTASIS.

1964 • 23 citations

The Effect of Insulin Deficiency on the Glutathione-Insulin Transhydrogenase Activity of Rat Liver

1973 • 23 citations

Turnover of hepatic glutathione-insulin transhydrogenase (disulfide interchange enzyme) in normal and diabetic rats utilizing a new simplified isolation procedure.

1980 • 22 citations

Substrate Studies for Insulin-Specific Protease

1973 • 22 citations

Breakdown of exogenous insulin by langerhans islets of the pancreas in vitro☆

1974 • 22 citations

Immunochemical Studies on the Insulin-degrading Enzyme from Pig and Rat Skeletal Muscle

1980 • 21 citations

The Importance of Proteolysis as the Initial Step of Insulin Degradation in Rat Liver Homogenates*

1979 • 21 citations

The Binding and Degradation of Insulin by Rat Liver Membranes: Demonstration of Three Distinct Insulin-Binding Components in Detergent-Solubilized Material from Liver Plasma Membrane*

1980 • 21 citations

Inhibition of degradation of insulin by ophthalamic acid and by a bovine pancreatic proteinase inhibitor

1979 • 20 citations

The degradation of semisynthetic tritiated insulin by perfused mouse livers

1976 • 19 citations

The Effect of Insulin on Fat Cells: An Insulin Degrading System Extracted from Plasma Membranes of Insulin Responsive Cells

1972 • 19 citations

Insulin kinetics after portal and peripheral injection of [125I] insulin. I. Data analysis and modeling

1976 • 19 citations

Sites of cleavage of glucagon by insulin-glucagon protease

1975 • 19 citations

Cleavage of bovine insulin by rat adipose tissue

1968 • 19 citations

Decreased Insulin Binding and Degradation Associated with Depressed Intracellular ATP Content

1980 • 19 citations

Labeled Insulin Catabolism in Chronic Renal Failure and in the Anephric State

1971 • 17 citations

The effect of hydrocortisone phosphate, methylprednisolone and phenytoin on pancreatic insulin release and hepatic glutathione-insulin transhydrogenase activity in the rat

1975 • 16 citations

Mechanisms of acute hyperinsulinemia after Kupffer cell phagocytosis

1980 • 16 citations

Presence of two different types of protein-disulfide isomerase on cytoplasmic and luminal surfaces of endoplasmic reticulum of rat liver cells

1977 • 16 citations

Urinary insulin levels in health and disease—a concise review

1975 • 16 citations

Resolution of Ox Liver Thiol-Disulphide Oxidoreductases by a New Application of Covalent Chromatography

1979 • 16 citations

Insulin degradation XXV. Glutathione-insulin transhydrogenase activity of rat liver and kidney during the development of stretptozotocin-diabetes

1979 • 16 citations

Insulin-Like Activities and Insulin-Potentiating Actions of a Modified Insulin B_21–26Fragment: β-Ala-Arg-Gly-Phe-Phe-Tyr-NH₂

1977 • 16 citations

Insulin Binding and Response in Erythroblastic Leukemic Cells

1980 • 15 citations

Effect of nephrectomy and acute uremia on plasma insulin- 125 I removal rate.

1971 • 15 citations

Nonsuppressible insulin-like activity of human serum. A potent inhibitor of insulin degradation.

1976 • 15 citations

Chloroquine inhibits the insulin production of isolated pancreatic islets

1980 • 14 citations

Liver Insulinase Activity in Insulin Deficient Rats

1968 • 14 citations

Autoregulatory System of Insulin Degradation in Liver

1972 • 14 citations

Clearance Studies of Insulin and Nonsuppressible Insulin-Like Activity (NSILA) in the Rat Liver.

1967 • 14 citations

Insulin Extraction from the Renal Peritubular Circulation in the Chicken

1977 • 13 citations

Degredation of insulin by a particulate fraction from adipose tissue

1970 • 12 citations

Differences Between Insulin Degradation by Soluble Fractions and Insulin Clearance by Perfused Livers of Normal, Protein-depleted, and Starved Rats

1977 • 12 citations

Studies on urea synthesis, insulin degradation and phagocytosis by isolated rat kupffer cells

1976 • 11 citations

Insulin receptor binding and degradation in IM-9 cultured human lymphocytes — Importance of extracellular degradation

1980 • 10 citations

The Insulin-Degrading Activity of Plasma-Membrane Fractions from Rat Liver

1977 • 10 citations

Glucose-Lowering Effect of Insulin by Different Routes in Obese and Lean Nonketotic Diabetic Patients*

1978 • 10 citations

The role of 'insulinase' in the degradation of insulin.

1973 • 9 citations

[Hepatic influence on labelled insulin metabolism].

1968 • 9 citations

Degradation of Porcine Insulin and Proinsulin by Rat Adipose Tissue

1971 • 8 citations

Studies on inhibitors of the insulin protease of rat liver

1977 • 6 citations

Hyperproinsulinemia in Hypoglycemic Subjects

1972 • 6 citations

Degradation Studies of Insulin in the Isolated Perfused Rat Liver, with and without Blocked Reticuloendothelial System

1971 • 5 citations

The Effect of Hypophysectomy on the Glutathione—Insulin Transhydrogenase Activity of Rat Liver

1976 • 3 citations

Environmental Effects on Glutathione-Insulin Transhydrogenase in Rat Liver

1976 • 3 citations

Triacetylated insulin: Biologic activity and resistance to degradation

1976 • 2 citations

Receptor-bound insulin as a substrate for insulin degradation in adipocytes.

1979 • 1 citations