Insulin metabolism in rat hepatocytes. Evidence for generation of an insulin fragment missing a portion of the B chain involved in receptor binding.

Binding and degradation of 125I-insulin by rat hepatocytes.

1975 • 419 citations

Receptor-binding region of insulin

1976 • 389 citations

Peptide hormone binding to receptors: A review of direct studies in vitro

1973 • 286 citations

Insulin Metabolism and Degradation*

1981 • 197 citations

Lysosomal association of internalized 125I-insulin in isolated rat hepatocytes. Direct demonstration by quantitative electron microscopic autoradiography.

1979 • 174 citations

Ammonia inhibition of protein degradation in isolated rat hepatocytes

1976 • 172 citations

Insulin Today

1977 • 172 citations

The Metabolism of Proinsulin and Insulin by the Liver

1972 • 159 citations

Effect of Intraduodenal Glucose Administration on Hepatic Extraction of Insulin in the Anesthetized Dog

1973 • 134 citations

Uptake of insulin by plasmalemma and Golgi subcellular fractions of rat liver.

1980 • 116 citations

Metabolism of Insulin-I131 Studies in Isolated, Perfused Rat Liver and Hind-limb Preparations

1959 • 104 citations

Effect of chloroquine on the internalization of 125I-insulin into subcellular fractions of rat liver. Evidence for an effect of chloroquine on Golgi elements.

1982 • 102 citations

Lysosomal Degradation of Receptor-bound 125I-labeled Insulin by Rat Adipocytes: Its Characterization and Dissociation from the Short-term Biologic Effects of Insulin

1980 • 96 citations

Mode of uptake and degradation of ¹²⁵I-labelled insulin by isolated hepatocytes and H4 hepatoma cells

1979 • 94 citations

Characterization of insulin-like actions of anti-insulin receptor antibodies. Effects on insulin binding, insulin degradation, and glycogen synthesis in isolated rat hepatocytes.

1980 • 86 citations

Initial site of insulin cleavage by insulin protease.

1979 • 84 citations

Insulin Degradation by Hepatocytes in Primary Culture*

1981 • 78 citations

Studies on the Specificity and Mechanism of Action of Hepatic Glutathione-Insulin Transhydrogenase

1966 • 77 citations

Intracellular binding sites for insulin are immunologically distinct from those on the plasma membrane

1977 • 75 citations

Semisynthesis and biological activity of porcine [LeuB24]insulin and [LeuB25]insulin.

1980 • 75 citations

[127-I]- or carrier-free [125-I]monoiodoinsulin

1975 • 69 citations

Insulin removal by isolated perfused rat liver

1976 • 59 citations

Insulin degradation by insulin target cells

1981 • 56 citations

Insulin degradation X. Identification of insulin degrading activity of rat liver plasma membrane as glutathione-insulin transhydrogenase

1973 • 51 citations

Insulin-degrading Activity of Plasma Membranes from Rat Skeletal Muscle: Its Isolation, Characterization, and Biologic Significance

1979 • 49 citations

The preparation of a semisynthetic tritiated insulin with a specific radioactivity of up to 20 Curies per millimole

1975 • 44 citations

An Evaluation of the Importance of Lysosomal and Neutral Cytosol Proteases in Insulin Degradation by Adipocytes*

1981 • 42 citations

Increased Clearance and Degradation of [3H]Insulin in Streptozotocin Diabetic Rats

1981 • 33 citations

Structure and Activity of Insulin, XII. Further Studies on Biologically Active Synthetic Fragments of the B-Chain

1973 • 32 citations

Energy-Dependent Steps in Insulin-Hepatocyte Interaction*

1981 • 32 citations

Binding and Degradation of Semisynthetic Tritiated Insulin by IM-9 Cultured Human Lymphocytes

1980 • 31 citations

Insulin degradation by lysosomal extracts from rat liver; model for a role of lysosomes in hormone degradation

1976 • 27 citations

[(125I]IodotyrosylB1]insulin. Semisynthesis, receptor binding, and cell-mediated degradation of a B chain-labeled insulin.

1981 • 27 citations

Effects of Dichloroacetate on Lipid Metabolism in Isolated Rat Liver Cells

1979 • 20 citations

Insulin-Like Activities and Insulin-Potentiating Actions of a Modified Insulin B_21–26Fragment: β-Ala-Arg-Gly-Phe-Phe-Tyr-NH₂

1977 • 16 citations

Effect of insulin fragments on biological activity of insulin and desoctapeptide insulin. I. Potentiation of biological activities.

1981 • 13 citations

Synthesis of tritiated rat insulin with high specific activity: A method for radiolabeling the active site of insulin

1981 • 4 citations

125I-insulin metabolism by rat liver cells: preferential binding and degradation of insulin labeled at TyrA14.

1982 • 2 citations

Abstracts EASD, 16th annual meeting, Athens, September 24?27, 1980

1980 • 2 citations