Internalization and degradation of fat cell-bound insulin. Separation and partial characterization of subcellular vesicles associated with iodoinsulin.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The Thiobarbituric Acid Assay of Sialic Acids

1959 • 6,482 citations

Metabolism of Isolated Fat Cells

1964 • 4,431 citations

Intracellular Aspects of the Process of Protein Synthesis

1975 • 3,560 citations

Immunoassay of insulin with insulin-antibody precipitate

1963 • 2,632 citations

Lysosomotropic agents

1974 • 1,887 citations

An enzymic method for the trace iodination of immunoglobulins and other proteins

1969 • 1,414 citations

125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.

1976 • 1,293 citations

Endocytosis

1977 • 1,275 citations

Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture

1974 • 1,037 citations

Preparation and properties of plasma membrane and endoplasmic reticulum fragments from isolated rat fat cells

1971 • 838 citations

THE ENZYMATIC IODINATION OF THE RED CELL MEMBRANE

1972 • 709 citations

Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells

1978 • 647 citations

PROTEIN DEGRADATION IN CULTURED CELLS

1974 • 603 citations

The Relationship between the Insulin-binding Capacity of Fat Cells and the Cellular Response to Insulin

1971 • 464 citations

Enzymatic Radioiodination of Gonadotropins

1972 • 435 citations

Binding and degradation of 125I-insulin by rat hepatocytes.

1975 • 419 citations

Insulin Interactions with Liver Plasma Membranes

1972 • 396 citations

A new assay for cathepsin B1 and other thiol proteinases

1972 • 394 citations

PINOCYTOSIS IN FIBROBLASTS

1974 • 389 citations

A procedure for measurement of distribution spaces in isolated fat cells

1972 • 366 citations

Binding and degradation of 125I-labelled insulin by isolated rat fat cells

1973 • 339 citations

Effects of local anesthetics on membrane properties I. Changes in the fluidity of phospholipid bilayers

1975 • 337 citations

Inherited Disorders of Lysosomal Metabolism

1975 • 322 citations

INHIBITION OF PHAGOCYTOSIS AND PLASMA MEMBRANE MOBILITY OF THE CULTIVATED MACROPHAGE BY CYTOCHALASIN B

1974 • 289 citations

The dissociation of the attachment and ingestion phases of phagocytosis by macrophages

1967 • 228 citations

Binding and uptake of 125I-insulin into rat liver hepatocytes and endothelium. An in vivo radioautographic study.

1979 • 223 citations

Intracellular Translocation of Iodine-125-Labeled Insulin: Direct Demonstration in Isolated Hepatocytes

1978 • 220 citations

Insulin-sensitive phosphodiesterase. Its localization, hormonal stimulation, and oxidative stabilization.

1975 • 203 citations

Intracellular polypeptide hormone receptors. The demonstration of specific binding sites for insulin and human growth hormone in Golgi fractions isolated from the liver of female rats.

1978 • 196 citations

EFFECT OF PHAGOCYTOSIS ON MEMBRANE TRANSPORT OF NONELECTROLYTES

1971 • 190 citations

The fate of insulin bound to adipocytes. Evidence for compartmentalization and processing.

1978 • 189 citations

Binding and receptor-mediated degradation of insulin in adipocytes

1978 • 180 citations

Actions of insulin in fat cells. Effects of low temperature, uncouplers of oxidative phosphorylation, and respiratory inhibitors.

1977 • 175 citations

Insulin Today

1977 • 172 citations

125I-insulin binding to cultured human lymphocytes. Initial localization and fate of hormone determined by quantitative electron microscopic autoradiography.

1978 • 171 citations

Degradation of receptor-bound human choriogonadotropin by murine Leydig tumor cells.

1978 • 165 citations

Effect of Insulin and Lipolytic Agents on Rat Adipocyte Low K Cyclic Adenosine 3′ : 5′-Monophosphate Phosphodiesterase

1974 • 165 citations

Destruction and Restoration of the Insulin Effector System of Isolated Fat Cells

1969 • 161 citations

Retention and degradation of 125I-insulin by perfused livers from diabetic rats.

1976 • 135 citations

Entry of Insulin Into Human Cultured Lymphocytes: Electron Microscope Autoradiographic Analysis

1978 • 135 citations

Intracellular polypeptide hormone receptors. Characterization of insulin binding sites in Golgi fractions from the liver of female rats.

1978 • 123 citations

Purification and partial characterization of collagenolytic enzymes from Clostridium histolyicum

1968 • 120 citations

AUTOPHAGIC VACUOLES PRODUCED IN VITRO

1968 • 118 citations

Mammalian α-Acetylglucosaminidase. Enzymic Properties, Tissue Distribution, and Intracellular Localization^*

1967 • 92 citations

Electron Microscopic Demonstration of Insulin Receptors on Adipocyte Plasma Membranes Utilizing a Ferritin-Insulin Conjugate

1974 • 90 citations

Lysosomes in rat-kidney tissue

1965 • 67 citations

Does Insulin Need a Second Messenger?

1977 • 66 citations

Insulin stimulation of glucose transport in adipose cells. An energy-dependent process

1977 • 65 citations

Sugar transport in fat cells: Effects of mechanical agitation, cell-bound insulin, and temperature

1979 • 64 citations

Insulin Degradation by Isolated Fat Cells and their Subcellular Fractions

1975 • 42 citations

THE ISOLATION OF LYSOSOMES FROM EHRLICH ASCITES TUMOR CELLS FOLLOWING PRETREATMENT OF MICE WITH TRITON WR-1339

1969 • 34 citations

RADIORECEPTOR ASSAY FOR INSULIN

1976 • 17 citations