Surface binding and rates of internalization of 125I-insulin in adipocytes and IM-9 lymphocytes.

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Metabolism of Isolated Fat Cells

1964 • 4,431 citations

Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells.

1980 • 798 citations

Binding and degradation of 125I-insulin by rat hepatocytes.

1975 • 419 citations

Insulin-Receptor Interaction in the Obese-Hyperglycemic Mouse

1973 • 408 citations

Characteristics of the Human Lymphocyte Insulin Receptor

1973 • 320 citations

The fate of insulin bound to adipocytes. Evidence for compartmentalization and processing.

1978 • 189 citations

Temperature dependence of endocytosis mediated by the asialoglycoprotein receptor in isolated rat hepatocytes. Evidence for two potentially rate-limiting steps.

1981 • 187 citations

Effects of lysosomotropic agents on insulin interactions with adipocytes. Evidence for a lysosomal pathway for insulin processing and degradation.

1979 • 185 citations

Binding and receptor-mediated degradation of insulin in adipocytes

1978 • 180 citations

Actions of insulin in fat cells. Effects of low temperature, uncouplers of oxidative phosphorylation, and respiratory inhibitors.

1977 • 175 citations

125I-insulin binding to cultured human lymphocytes. Initial localization and fate of hormone determined by quantitative electron microscopic autoradiography.

1978 • 171 citations

Evidence for recycling of insulin receptors in isolated rat adipocytes.

1981 • 165 citations

Internalization and degradation of fat cell-bound insulin. Separation and partial characterization of subcellular vesicles associated with iodoinsulin.

1979 • 161 citations

Effects of fasting on insulin binding, glucose transport, and glucose oxidation in isolated rat adipocytes: relationships between insulin receptors and insulin action.

1976 • 160 citations

Entry of Insulin Into Human Cultured Lymphocytes: Electron Microscope Autoradiographic Analysis

1978 • 135 citations

Water-Soluble Insulin Receptors from Human Lymphocytes

1972 • 108 citations

Evidence for insulin-induced internalization and degradation of insulin receptors in rat adipocytes.

1982 • 105 citations

Lysosomal Degradation of Receptor-bound 125I-labeled Insulin by Rat Adipocytes: Its Characterization and Dissociation from the Short-term Biologic Effects of Insulin

1980 • 96 citations

Insulin Degradation by Hepatocytes in Primary Culture*

1981 • 78 citations

Polypeptide Hormones: Intracellular Receptors and Internalization

1981 • 77 citations

Receptor-Mediated Binding and Internalization of Toxins and Hormones

1981 • 73 citations

Regulation of insulin receptors: evidence for involvement of an endocytotic internalization pathway.

1980 • 72 citations

Functional relationships between insulin binding, action, and degradation. A reassessment.

1980 • 68 citations

Insulin receptors of cultured human lymphocytes (IM-9). Lack of receptor-mediated degradation.

1980 • 67 citations

Interactions Between Insulin and Its Receptors After the Initial Binding Event: Functional Heterogeneity and Relationships to Insulin Degradation

1979 • 66 citations

The Endocytotic-Internalization Pathway of Insulin Metabolism: Relationship to Insulin Degradation and Activation of Glucose Transport*

1980 • 63 citations

Insulin Binding, Internalization, and Insulin Receptor Regulation in Fibroblasts from Type II, Non-insulin-dependent Diabetic Subjects

1981 • 48 citations

Photoaffinity Labeling of Insulin Receptors in Viable Cultured Human Lymphocytes: Demonstration of Receptor Shedding and Degradation

1982 • 47 citations

REgulation of insulin binding to isolated hepatocytes: correction for bound hormone fragments linearizes Scatchard plots.

1980 • 43 citations

Characterization of a mutant human insulin species.

1980 • 36 citations

Properties and partial purification of the detergent-solubilized insulin receptor A demonstration of negative cooperativity in micellar solution

1978 • 28 citations

[(125I]IodotyrosylB1]insulin. Semisynthesis, receptor binding, and cell-mediated degradation of a B chain-labeled insulin.

1981 • 27 citations