Energy-Dependent Steps in Insulin-Hepatocyte Interaction*

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

THE PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY

1963 • 10,322 citations

HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS

1969 • 4,428 citations

Intracellular Protein Degradation in Mammalian and Bacterial Cells

1974 • 1,775 citations

Cellular Energy Metabolism and its Regulation

1977 • 961 citations

A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes

1978 • 622 citations

PROTEIN DEGRADATION IN CULTURED CELLS

1974 • 603 citations

Site-site interactions among insulin receptors. Characterization of the negative cooperativity.

1976 • 601 citations

Membrane receptors for hormones and neurotransmitters.

1976 • 573 citations

A soluble ATP-dependent proteolytic system responsible for the degradation of abnormal proteins in reticulocytes.

1977 • 553 citations

Monoiodoinsulin: Demonstration of its biological activity and binding to fat cells and liver membranes

1971 • 521 citations

Inhibition of the Lysosomal Pathway of Protein Degradation in Isolated Rat Hepatocytes by Ammonia, Methylamine, Chloroquine and Leupeptin

1979 • 466 citations

Binding and degradation of 125I-insulin by rat hepatocytes.

1975 • 419 citations

Insulin-Receptor Interaction in the Obese-Hyperglycemic Mouse

1973 • 408 citations

Cooperativity in ligand binding: A new graphic analysis

1975 • 369 citations

The Insulin Receptor: Its Role in Insulin Resistance of Obesity and Diabetes

1976 • 289 citations

Peptide hormone binding to receptors: A review of direct studies in vitro

1973 • 286 citations

Selective control of the degradation of normal and aberrant proteins in Reuber H35 hepatoma cells

1976 • 234 citations

Mapping of the residues responsible for the negative cooperativity of the receptor-binding region of insulin

1978 • 223 citations

Intracellular Translocation of Iodine-125-Labeled Insulin: Direct Demonstration in Isolated Hepatocytes

1978 • 220 citations

The permeability properties of the lysosomal membrane

1977 • 198 citations

The fate of insulin bound to adipocytes. Evidence for compartmentalization and processing.

1978 • 189 citations

Binding and receptor-mediated degradation of insulin in adipocytes

1978 • 180 citations

Actions of insulin in fat cells. Effects of low temperature, uncouplers of oxidative phosphorylation, and respiratory inhibitors.

1977 • 175 citations

Cooperative properties of hormone receptors in cell membranes

1976 • 170 citations

Insulin Binding to Isolated Human Adipocytes

1974 • 106 citations

Mode of uptake and degradation of ¹²⁵I-labelled insulin by isolated hepatocytes and H4 hepatoma cells

1979 • 94 citations

Electron Microscopic Demonstration of Insulin Receptors on Adipocyte Plasma Membranes Utilizing a Ferritin-Insulin Conjugate

1974 • 90 citations

Intracellular localization of 125I-labeled insulin in hepatocytes from intact rat liver.

1979 • 84 citations

Insulin stimulation of glucose transport in adipose cells. An energy-dependent process

1977 • 65 citations

Role of insulin secretagogues in the regulation of somatostatin binding by isolated rat islets.

1980 • 64 citations

Insulin Binding to Adipocytes: Evidence for Functionally Distinct Receptors

1978 • 63 citations

CHANGE IN AFFINITY OF INSULIN RECEPTORS FOLLOWING ORAL GLUCOSE IN NORMAL ADULTS

1977 • 54 citations

Further evidence for a proton pump in mouse kidney phagolysosomes: Effect of nigericin and 2,4-dinitrophenol on the stimulation of intralysosomal proteolysis by ATP

1975 • 44 citations

What is the molecular basis for the action of insulin?

1979 • 36 citations

New intracellular proteases and their role in intracellular enzyme degradation

1977 • 24 citations

THE MECHANISM OF ACTION OF POLYPEPTIDE HORMONES WITH SPECIAL REFERENCE TO INSULIN'S ACTION ON GLUCOSE TRANSPORT

1977 • 21 citations

Decreased Insulin Binding and Degradation Associated with Depressed Intracellular ATP Content

1980 • 19 citations

Insulin-stimulated sugar transport and 125I-insulin binding by rat soleus muscle: Permissive effect of ATP

1977 • 14 citations

Permissive effect of ATP on insulin-stimulated sugar transport by rat soleus muscle.

1978 • 13 citations

The Biogenesis of Organelles

1974 • 9 citations

The Network of Intracellular Membranes

1973 • 7 citations