Antimutagens as cancer chemopreventive agents in the diet

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Revised methods for the Salmonella mutagenicity test

1983 • 7,295 citations

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

1983 • 3,602 citations

Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence

1992 • 3,313 citations

Dietary Carcinogens and Anticarcinogens

1983 • 3,028 citations

Chemoprevention of Cancer

2008 • 1,269 citations

Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands

1993 • 1,239 citations

Vegetables, fruit, and cancer. II. Mechanisms

1991 • 805 citations

Endogenous mutagens and the causes of aging and cancer

1991 • 725 citations

Endogenous Oxidative DNA Damage, Aging, and Cancer

1989 • 711 citations

Carcinogenicity of Butylated Hydroxyanisole in F344 Rats<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref><xref ref-type="fn" rid="fn4">4</xref>

1983 • 574 citations

Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles.

1978 • 432 citations

Cancer chemoprevention: principles and prospects

1993 • 416 citations

Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials: a review.

1990 • 402 citations

Rationale and strategies for chemoprevention of cancer in humans.

1987 • 366 citations

The Data Support a Role for Antioxidants in Reducing Cancer Risk

2009 • 330 citations

Dietary inhibitors of mutagenesis and carcinogenesis

1988 • 314 citations

Inhibitors of endogenous nitrosation mechanisms and implications in human cancer prevention

1988 • 297 citations

Mechanisms of inhibitors of mutagenesis and carcinogenesis. Classification and overview

1988 • 290 citations

Antimutagens and anticarcinogens: A survey of putative interceptor molecules

1990 • 268 citations

Occurrence, identification, and bacterial mutagenicity of heterocyclic amines in cooked food

1991 • 258 citations

The formation and occurrence of polynuclear aromatic hydrocarbons associated with food

1991 • 240 citations

Mutagenic spectrum resulting from DNA damage by oxygen radicals

1991 • 237 citations

Chlorophyllin: a potent antimutagen against environmental and dietary complex mixtures

1986 • 212 citations

Free radicals in tumor promotion

1986 • 198 citations

Site-specific DNA cleavage by mammalian DNA topoisomerase II induced by novel flavone and catechin derivatives

1992 • 174 citations

Dietary fibre: its composition and role in protection against colorectal cancer

1993 • 162 citations

Mycotoxins: food contamination, mechanism, carcinogenic potential and preventive measures

1991 • 160 citations

Inhibitors of mutagenesis and their relevance to carcinogenesis

1986 • 156 citations

Effects of indole-3-carbinol on lung tumorigenesis and DNA methylation induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and on the metabolism and disposition of NNK in A/J mice.

1990 • 150 citations

Relative value of carotenoids as precursors of vitamin A

1983 • 141 citations

Carotenoid Analyses of Selected Raw and Cooked Foods Associated With a Lower Risk for Cancer

1990 • 132 citations

Carcinogenic factors in food with relevance to colon cancer development

1993 • 122 citations

Inhibitory effect of chlorophyll on the genotoxicity of 3-amino-1-methyl-5H-pyrido[4,3-b indole (Trp-P-2)

1989 • 119 citations

Naturally Occurring Anticarcinogenic Substances in Foodstuffs

1985 • 114 citations

Chemopreventive properties of chlorophyllin: inhibition of aflatoxin B₁ (AFB₁)-DNA binding in vivo and anti-mutagenic activity against AFB₁ and two heterocyclic amines in the salmonella mutagenicity assay

1991 • 110 citations

Quantitative inter-relationships between aflatoxin B1 carcinogen dose, indole-3-carbinol anti-carcinogen dose, target organ DNA adduction and final tumor response

1989 • 101 citations

Tannins as Potent Inhibitors of DNA Topoisomerase II In Vitro

1993 • 100 citations

Antimutagenesis in microbial systems

1975 • 99 citations

Multiple dietary factors in the enhancement of dimethylhydrazine carcinogenesis: main effect of indole-3-carbinol.

1986 • 93 citations

Mammalian cell mutagenicity and metabolism of heterocyclic aromatic amines

1991 • 90 citations

Inhibitory effects of flavourings on mutagenesis induced by chemicals in bacteria

1986 • 87 citations

Screening for chemopreventive (anticarcinogenic) compounds in rodents

1992 • 82 citations

Comparative antimutagenicity of 5 compounds against 5 mutagenic complex mixtures in Salmonella typhimurium strain TA98

1989 • 79 citations

Induction of Tumours by Tannin Extracts

1960 • 77 citations

Chlorophyll: The active factor in wheat sprout extract inhibiting the metabolic activation of carcinogens in vitro

1979 • 73 citations

Protection by chlorophyllin against the covalent binding of 2-amino-3-methylimidazo[4,5-f]qiiinoline (IQ) to rat liver DNA

1992 • 73 citations

Post-replication repair and recombination in uvrA umuC strains of Escherichia coli are enhanced by vanillin, an antimutagenic compound

1988 • 72 citations

The Carotene and Retinol Efficacy Trial (CARET) to prevent lung cancer in high-risk populations: pilot study with cigarette smokers.

1993 • 72 citations

Chlorophyllin is both a positive and negative modifier of mutagenicity

1992 • 71 citations

Antimutagenic potency of chlorophyllin in the salmonella assay and its correlation with binding constants of mutagen‐inhibitor complexes

1993 • 64 citations

Vitamin A, carotenoids, and retinoids

1986 • 64 citations

Modification of Genotoxicity by Naturally Occurring Flavorings and Their Derivatives

1993 • 56 citations

Antimutagenicity profiles of some natural substances

1992 • 56 citations

Effects of disulfiram, diethyldithiocarbamate, bisethylxanthogen, and benzyl isothiocyanate on glutathione transferase activities in mouse organs.

1985 • 55 citations

Modulation of the mutagenic response in prokaryotes

1992 • 53 citations

Chlorophyllin, an antimutagen, acts as a tumor promoter in the rat-dimethylhydrazine colon carcinogenesis model.

1992 • 52 citations

Inhibition of 2-amino-3-methylimidazo[4.5-f] (IQ)-DNA binding by chlorophyllin: studies of enzyme inhibition and molecular complex formation

1992 • 52 citations

The epidemiological evidence concerning intake of mutagenic activity from the fried surface and the risk of cancer cannot justify preventive measures

1993 • 48 citations

Inhibition of in vitro metabolic activation of carcinogens by wheat sprout extracts

1978 • 48 citations

Antimutagenesis by factors affecting DNA repair in bacteria

1988 • 47 citations

Chemical carcinogens and inhibitors of carcinogenesis in the human diet

1985 • 43 citations

Contrasting effects of SH-compounds on oxidative DNA damage: repair and increase of damage

1993 • 41 citations

Synthesis and chemical carcinogen inhibitory activity of 2-tert-butyl-4-hydroxyanisole

1979 • 40 citations

The metabolic activation of 4-nitro-o-phenylenediamine by chlorophyll-containing plant extracts: The relationship between mutagenicity and antimutagenicity

1991 • 39 citations

The adsorption of a range of dietary carcinogens by α-cellulose, a model insoluble dietary fiber

1993 • 38 citations

Mutagens and carcinogens produced by the reaction of environmental aromatic compounds with nitrite.

1989 • 36 citations

Problems and prospects in antimutagenesis and anticarcinogenesis

1988 • 30 citations

Adsorption of a hydrophobic mutagen to dietary fibre from the skin and flesh of potato tubers

1991 • 29 citations

Antimutagenesis Studies in Japan

1990 • 20 citations

Condensed tannins induce micronuclei in cultured V79 Chinese hamster cells

1985 • 19 citations

Antigenotoxic Activity of Carotenoids in Carcinogen-Exposed Populations

1990 • 16 citations

Antimutagenesis by shift in monooxygenase isoenzymes and induction of epoxide hydrolase

1988 • 16 citations

Hypothesis on the relationship between gastric cancer and intragastric nitrosation: N-nitrosamines in gastric juice of subjects from a high-risk area for gastric cancer and the inhibition of N-nitrosamine formation by fruit juices.

1993 • 15 citations

Specificity of Antimutagens against Chemical Mutagens in Microbial Systems

1990 • 13 citations

Inhibition of Chemical Carcinogenesis

1989 • 12 citations

The Concept of Activity Profiles of Antimutagens

1990 • 7 citations