Antimutagenicity profiles of some natural substances

Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids).

1976 • 993 citations

Artificial transmutation of the gene

1996 • 966 citations

Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials: a review.

1990 • 402 citations

Chemoprevention of cancer with retinoids

1981 • 367 citations

Rationale and strategies for chemoprevention of cancer in humans.

1987 • 366 citations

Mechanisms of inhibitors of mutagenesis and carcinogenesis. Classification and overview

1988 • 290 citations

Antimutagenicity profiles for some model compounds

1990 • 284 citations

Antimutagens and anticarcinogens: A survey of putative interceptor molecules

1990 • 268 citations

Vitamin A acid (retinoic acid), a potent inhibitor of 12-O-tetradecanoyl-phorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis.

1977 • 234 citations

The Cytochrome P450 I Gene Family of Microsomal Hemoproteins and Their Role in the Metabolic Activation of Chemicals

1990 • 222 citations

New pathway for retinol metabolism in liver microsomes.

1985 • 159 citations

Reversible inhibition by retinoids of 3-methylcholanthrene-induced neoplastic transformation in C3H/10T1/2 clone 8 cells.

1979 • 154 citations

Inhibition of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis by retinyl acetate.

1976 • 149 citations

13- cis -Retinoic Acid: Inhibition of Bladder Carcinogenesis Induced in Rats by N -Butyl- N -(4-hydroxybutyl)nitrosamine

1977 • 112 citations

Antimutagenesis and Anticarcinogenesis Mechanisms II

1990 • 95 citations

Use of computerized data listings and activity profiles of genetic and related effects in the review of 195 compounds

1988 • 88 citations

Anti-mutagens

1952 • 84 citations

Substrate specificities and functions of the P450 cytochromes

1990 • 79 citations

Vitamin A compounds and analogs as inhibitors of mixed-function oxidases that metabolize carcinogenic polycyclic hydrocarbons and other compounds.

1974 • 79 citations

Screening of antioxidants and other compounds for antimutagenic properties towards benzo[a]pyrene-induced mutagenicity in strain TA98 of Salmonella typhimurium

1982 • 76 citations

Modifying role of dietary factors on the mutagenicity of aflatoxin B1: In vitro effect of vitamins

1987 • 74 citations

Retinoids: Tumor Preventers or Tumor Enhancers?4

1980 • 71 citations

Inhibition of Benzo[<italic>a</italic>]pyrene-Induced Mammary Carcinogenesis by Retinyl Acetate<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1981 • 67 citations

Retinol (vitamin A) as an inhibitor of the mutagenicity of aflatoxin B1

1980 • 58 citations

Comparative antimutagenicity of chlorophyllin and five other agents against aflatoxin B₁‐induced reversion in Salmonella typhimurium strain TA98

1988 • 56 citations

Factors modulating the formation of DNA adduct by aflatoxin B₁ in vitro

1984 • 55 citations

Inhibition of rat mammary carcinogenesis by short dietary exposure to retinyl acetate.

1980 • 55 citations

Effects of vitamins A, C, and E on aflatoxin B₁‐induced mutagenesis in Salmonella typhimurium TA‐98 and TA‐100

1985 • 45 citations

Inhibition of protein pyrolysate mutagenicity by retinol (Vitamin A)

1982 • 43 citations

Retinol (vitamin A) inhibits sister chromatid exchanges and cell cycle delay induced by cyclophosphamide and aflatoxin B₁ in Chinese hamster V79 cells

1982 • 42 citations

Utility of short‐term tests for genetic toxicity in the aftermath of the NTP's analysis of 73 chemicals

1988 • 40 citations

Anticlastogenic effect of β-carotene in Chinese hamsters time and dose response studies with different mutagens

1985 • 38 citations

Inhibition of carcinogenesis by retinoids.

1980 • 37 citations

Inhibition of 2-Fluorenamine-Induced Mutagenesis in <italic>Salmonella typhimurium</italic> by Vitamin A<xref ref-type="fn" rid="FN2">2</xref>

1979 • 35 citations

Effect of retinoids on carcinogen-induced mutagenesis in Salmonella tester strains

1985 • 30 citations

Retinoids as inhibitors of ortho-aminoazotoluene-induced mutagenesis in the Salmonella/liver microsome test

1982 • 30 citations

Influence of retinol on carcinogen‐induced sister chromatid exchanges and chromosome aberrations in V79 cells

1985 • 29 citations

Retinol (vitamin A) as a modifier of 2-aminofluorene and 2-acetyl-aminofluorene mutagenesis in the Salmonella/microsome assay

1982 • 29 citations

Effects of vitamin A on cyclophosphamide mutagenicity in vitro (Ames test) and in vivo (mouse micronucleus test)

1984 • 29 citations

Retinol (vitamin A) inhibition of dimethylnitrosamine (DMN) and diethylnitrosamine (DEN) induced sister-chromatid exchanges in V79 cells and mutations in Salmonella/microsome assays

1987 • 27 citations

Mechanism of the in vitro antimutagenic action of retinol

1990 • 24 citations

Effect of retinoids on plating efficiency, sister-chromatid exchange (SCE) and mitomycin-C-induced SCE in cultured Chinese hamster cells

1981 • 19 citations

Complex effects of retinol on the metabolic activation of 2‐aminofluorene

1983 • 18 citations

Induction of sister-chromatid exchanges and cell-cycle delays in human lymphocytes by vitamin A alone in or in combination with melphalan and caffeine

1985 • 16 citations

Influence of mouse liver stored vitamin A on the induction of mutations (Ames tests) and SCE of bone marrow cells by aflatoxin B₁, benzo(a)pyrene, or cyclophosphamide

1986 • 15 citations

Retinoids as modulators of metabolism: their inhibitory effect on cyclophosphamide and 7, 12-dimethylbenz[a]anthracene induced sister chromatid exchanges in a metabolically competent cell line

1990 • 12 citations

Modulation of ultraviolet light‐, ethyl methanesulfonate‐, and 7, 12‐dimethylbenz[a]anthracene‐induced unscheduled dna synthesis by retinol and retinoic acid in the primary rat hepatocyte

1987 • 11 citations

Inhibition of 7,12-dimethylbenz[a]anthracene-induced genotoxicity in Chinese hamster ovary cells by retinol and retinoic acid

1988 • 8 citations

The Concept of Activity Profiles of Antimutagens

1990 • 7 citations

Are short‐term genetic tests useful for predicting carcinogenicity? a panel discussion revisited

1990 • 6 citations