Antimutagenesis by shift in monooxygenase isoenzymes and induction of epoxide hydrolase

Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test

1975 • 7,413 citations

Mammalian Epoxide Hydrases: Inducible Enzymes Catalysing the Inactivation of Carcinogenic and Cytotoxic Metabolites Derived from Aromatic and Olefinic Compounds

1973 • 825 citations

Epoxides in Polycyclic Aromatic Hydrocarbon Metabolism and Carcinogenesis

1974 • 739 citations

Biological Reactive Intermediates

1977 • 597 citations

Arene oxides and the NIH shift: The metabolism, toxicity and carcinogenicity of aromatic compounds

1972 • 593 citations

Microsomes, Drug Oxidations and Chemical Carcinogenesis

1980 • 498 citations

Hepatic epoxide hydrase. Structure-activity relations for substrates and inhibitors

1971 • 316 citations

Metabolism of benzo(a)pyrene and benzo (a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes.

1976 • 316 citations

The Molecular Biology of Cancer

1974 • 298 citations

Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse

1975 • 245 citations

Purification and specificity of a human microsomal epoxide hydratase

1974 • 165 citations

Conversion of naphthalene to trans-naphthalene dihydrodiol: Evidence for the presence of a coupled aryl monooxygenase-epoxide hydrase system in hepatic microsomes

1972 • 151 citations

Hepatic microsomal epoxide hydrase: a sensitive radiometric assay for hydration of arene oxides of carcinogenic aromatic hydrocarbons.

1977 • 147 citations

The apparent ubiquity of epoxide hydratase in rat organs

1977 • 145 citations

Epoxides as microsomal metabolites of polycyclic hydrocarbons

1971 • 144 citations

Purification of rat liver epoxide hydratase to apparent homogeneity

1975 • 126 citations

A rapid assay for epoxide hydratase activity with benzo(a)pyrene 4,5-(K-region-)oxide as substrate

1976 • 120 citations

Induction, activation and inhibition of epoxide hydrase: an anomalous prevention of chlorobenzene-induced hepatotoxicity by an inhibitor of epoxide hydrase

1973 • 115 citations

Dependence of specific metabolism of benzo(a)pyrene on the inducer of hydroxylase activity.

1974 • 105 citations

Dual role of epoxide hydratase in both activation and inactivation of benzo(a)pyrene

1977 • 101 citations

Inactivation of electrophilic metabolites by glutathione S-transferases and limitation of the system due to subcellular localization

1977 • 89 citations

Epoxides metabolically produced from some known carcinogens and from some clinically used drugs. I. Differences in mutagenicity

1975 • 84 citations

Distribution of enzymes involved in metabolism of polycyclic aromatic hydrocarbons among rat liver endomembranes and plasma membranes.

1980 • 84 citations

Epoxides Derived from Various Polycyclic Hydrocarbons as Substrates of Homogeneous and Microsome‐Bound Epoxide Hydratase

1976 • 82 citations

Effects of Butylated Hydroxyanisole on the Metabolism of Benzo[a]pyrene by Mouse Liver Microsomes2

1977 • 78 citations

Mutagenicity of phenanthrene and phenanthrene K-region derivatives

1979 • 70 citations

Phylogenetic distribution of epoxide hydratase in different vertebrate species, strains and tissues measured using three substrates

1978 • 69 citations

Trans-stilbene oxide: a selective inducer of rat liver epoxide hydratase.

1978 • 69 citations

Effects of Administration to Mice of Butylated Hydroxyanisole by Oral Intubation on Benzo[ a ]pyrene-Induced Pulmonary Adenoma Formation and Metabolism of Benzo[ a ]pyrene 2

1978 • 63 citations

Prevention of benzo(a)pyrene‐induced mutagenicity by homogeneous epoxide hydratase

1976 • 63 citations

Inactivation of a Diol Epoxide by Dihydrodiol Dehydrogenase But Not by Two Epoxide Hydrolases

1982 • 52 citations

Inactivation of a diol-epoxide and a K-region epoxide with high efficiency by glutathione transferase X.

1983 • 49 citations

The epoxide hydratase inducer trans-stilbene oxide shifts the metabolic epoxidation of benzo(a)pyrene from the bay- to the K-region and reduces its mutagenicity.

1979 • 41 citations

Purification and characterization of a new cytosolic glutathione S-transferase (glutathione S-transferase X) from rat liver

1983 • 37 citations

Metabolizing systems in short-term In vitro tests for carcinogenicity

1986 • 11 citations