Endogenous mutagens and the causes of aging and cancer

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Bilirubin Is an Antioxidant of Possible Physiological Importance

1987 • 3,406 citations

Dietary Carcinogens and Anticarcinogens

1983 • 3,028 citations

Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.

1981 • 2,777 citations

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

1991 • 2,172 citations

Free Radicals in Biology

1976 • 1,879 citations

Ascorbate is an outstanding antioxidant in human blood plasma.

1989 • 1,876 citations

The aging process.

1981 • 1,871 citations

The Chemical Basis of Radiation Biology

1987 • 1,843 citations

The chemical basis of radiation biology

1987 • 1,788 citations

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

1990 • 1,747 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Antioxidant defenses and lipid peroxidation in human blood plasma.

1988 • 1,253 citations

Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.

1990 • 1,100 citations

Cell Proliferation in Carcinogenesis

1990 • 1,063 citations

The Inheritance of Epigenetic Defects

1987 • 1,058 citations

DNA Repair Enzymes

1982 • 905 citations

Increased cell division as a cause of human cancer.

1990 • 894 citations

Transcriptional Regulator of Oxidative Stress-Inducible Genes: Direct Activation by Oxidation

1990 • 869 citations

Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues

1987 • 778 citations

Too Many Rodent Carcinogens: Mitogenesis Increases Mutagenesis

1990 • 773 citations

Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain.

1988 • 765 citations

Antioxidant activity of albumin-bound bilirubin.

1987 • 763 citations

Identification of a Gene Located at Chromosome 5q21 that Is Mutated in Colorectal Cancers

1991 • 758 citations

Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis

1990 • 741 citations

Endogenous Oxidative DNA Damage, Aging, and Cancer

1989 • 711 citations

The Dawn of Darwinian Medicine

1991 • 707 citations

Estrogens as a cause of human cancer: the Richard and Hinda Rosenthal Foundation award lecture.

1988 • 703 citations

Hydroxyl Free Radical Adduct of Deoxyguanosine: Sensitive Detection and Mechanisms of Formation

1986 • 660 citations

Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations.

1990 • 621 citations

Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis.

1988 • 589 citations

Oxidative damage to DNA: relation to species metabolic rate and life span.

1988 • 587 citations

Ranking Possible Carcinogenic Hazards

1987 • 570 citations

Chemically induced birth defects

1986 • 515 citations

Genomic 5-methyldeoxycytidine decreases with age.

1987 • 504 citations

Chemical carcinogenesis: too many rodent carcinogens.

1990 • 498 citations

Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid

1991 • 485 citations

Dietary pesticides (99.99% all natural).

1990 • 400 citations

Thymine glycol and thymidine glycol in human and rat urine: a possible assay for oxidative DNA damage.

1984 • 365 citations

Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA

1987 • 343 citations

A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures

1988 • 329 citations

Spontaneous cancer and its possible relationship to oxygen metabolism.

1980 • 298 citations

Human Lymphocytes Exposed to Low Doses of Ionizing Radiations Become Refractory to High Doses of Radiation as Well as to Chemical Mutagens that Induce Double-strand Breaks in DNA

1988 • 283 citations

Antioxidants, Aging, and Longevity

1984 • 279 citations

Nature's chemicals and synthetic chemicals: comparative toxicology.

1990 • 275 citations

Injection of mitochondria into human cells leads to a rapid replacement of the endogenous mitochondrial DNA

1988 • 275 citations

Modern Biological Theories of Aging

1987 • 274 citations

HUMAN TUMOR SUPPRESSOR GENES

1990 • 266 citations

Oxidative DNA and RNA damage in the livers of Sprague-Dawley rats treated with the hepatocarcinogen 2-nitropropane.

1989 • 250 citations

The Age Distribution of Cancer: Implications for Models of Carcinogenesis

1971 • 242 citations

Methods for detecting DNA damaging agents in humans : applications in cancer epidemiology and prevention

1988 • 230 citations

Mechanisms of induction of enzymes that protect against chemical carcinogenesis

1989 • 226 citations

Formation of 8-hydroxyguanine moiety in deoxyribonucleic acid on .gamma.-irradiation in aqueous solution

1985 • 224 citations

Anticarcinogenesis and Radiation Protection

1987 • 210 citations

Role of activation of protein kinase C in the stimulation of colonic epithelial proliferation and reactive oxygen formation by bile acids.

1987 • 199 citations

Hepatocarcinogenesis due to chronic liver cell injury in hepatitis B virus transgenic mice.

1990 • 199 citations

Radiation-induced Decomposition of the Purine Bases within DNA and Related Model Compounds

1985 • 193 citations

Diet, Nutrition, and Cancer A Critical Evaluation

1985 • 189 citations

Oxidative Stress and Tumour Cell Proliferation

1990 • 179 citations

Low dose radiation : biological bases of risk assessment

1989 • 162 citations

Hydroxymethyluracil DNA glycosylase in mammalian cells.

1984 • 157 citations

IARC monographs on the evaluation of carcinogenic risks to humans. v. 51: Coffee, tea, mate, methylxanthines and methylglyoxal

1991 • 154 citations

Third chronological supplement to the carcinogenic potency database: standardized results of animal bioassays published through December 1986 and by the National Toxicology Program through June 1987.

1990 • 147 citations

Potential role of conjugated bilirubin and copper in the metabolism of lipid peroxides in bile.

1987 • 146 citations

Chemical, Oncogene and Growth Factor Inhibition of Gap Junctional Intercellular Communication: An Integrative Hypothesis of Carcinogenesis

1990 • 145 citations

The age distribution of cancer: implications for models of carcinogenesis.

1971 • 141 citations

Immunoaffinity isolation of urinary 8-hydroxy-2′-deoxygunosine and 8-hydroxyguanine and quantitation of 8-hydroxy-2′deoxyguanosine in DNA by polyclonal antibodies

1991 • 135 citations

Micronutrients in health and in disease prevention

1991 • 127 citations

Some tautologous aspects of the comparison of carcinogenic potency in rats and mice

1985 • 126 citations

Genetic basis of multidrug resistance of tumor cells

1990 • 124 citations

Interspecies extrapolation in carcinogenesis: prediction between rats and mice.

1989 • 124 citations

Calorie restriction and cellular proliferation in various tissues of the female Swiss Webster mouse

1990 • 123 citations

Mechanisms of Tumor Promotion: Potential Role of Intercellular Communication

1983 • 119 citations

Chromosomal Aberrations: Basic and Applied Aspects

2011 • 118 citations

Are we winning the fight against cancer? An epidemiological assessment

1990 • 102 citations

c-H-ras and c-K-ras gene hypomethylation in the livers and hepatomas of rats fed methyl-deficient, amino acid-defined diets

1988 • 96 citations

5-hydroxymethylcytosine DNA glycosylase activity in mammalian tissue

1988 • 93 citations

Age-specific models of mortality and tumor onset for historical control animals in the National Toxicology Program's carcinogenicity experiments.

1986 • 91 citations

Background Levels of DNA Damage in the Population

1986 • 89 citations

Historical perspective: calories and energy expenditure in carcinogenesis

1987 • 88 citations

Cytogenetic damage induced by folate deficiency in mice is enhanced by caffeine.

1990 • 87 citations

Inflammation, oxidative DNA damage, and carcinogenesis.

1987 • 78 citations

Altered methylation of ras oncogenes in benzidine-induced B6C3F1 mouse liver tumors

1989 • 62 citations

DNA methylation and epigenetic defects in carcinogenesis

1987 • 61 citations

Mechanisms of DNA Damage and Repair: Implications for Carcinogenesis and Risk Assessment

1986 • 58 citations

Evaluation of the cocarcinogenic effect of wounding in Rous sarcoma virus tumorigenesis.

1989 • 57 citations

Successful use of short-term tests for academic purposes: Their use in identification of new environmental carcinogens with possible risk for humans

1988 • 57 citations

Stimulation of tyrosine-specific protein phosphorylation in the rat liver plasma membrane by oxygen radicals

1986 • 57 citations

Ranking the potential carcinogenic hazards to workers from exposures to chemicals that are tumorigenic in rodents.

1987 • 52 citations

Changing concepts in cancer prevention: limitations and implications for future research in environmental carcinogenesis.

1988 • 51 citations

Food restriction retards age-related histological changes in rat small intestine

1990 • 48 citations

Non-genotoxic carcinogenesis: implications for testing and extrapolation to man

1989 • 44 citations

Theories of carcinogenesis

1990 • 43 citations

Measuring oxidative damage in humans: relation to cancer and ageing.

1988 • 41 citations

Effect of Dose Rate on the Induction of Experimental Lung Cancer in Hamsters by α Radiation

1985 • 40 citations

Mutagens: Some possible health impacts beyond carcinogenesis

1983 • 38 citations

Risks of Premature Death and Cancer Predicted by Body Weight in Early Adult Life

1991 • 36 citations

Threshold-Like Dose of Local β Irradiation Repeated Throughout the Life Span of Mice for Induction of Skin and Bone Tumors

1991 • 36 citations

Insecticides in health, agriculture and the environment

1974 • 33 citations

Measurement of Potato Steroidal Alkaloids in Human Serum and Saliva by Radioimmunoassay

1985 • 33 citations

Hypomethylation ofrasoncogenes in chemically induced and spontaneous b6c3f1 mouse liver tumors

1991 • 31 citations

Adaptation of Human Lymphocytes to Radiation or Chemical Mutagens: Differences in Cytogenetic Repair

1990 • 31 citations

Kinetics and retention of solanidine in man

1982 • 30 citations

In vitro analysis of modulators of intercellular communication: Implications for biologically, based risk assessment models for chemical exposure

1990 • 29 citations

Expression of Oxidant Stress-Related Genes in Tumor Promotion of Mouse Epidermal Cells JB6

1987 • 28 citations

Carcinogenic effect of the simultaneous administration of five heterocyclic amines to F344 rats.

1987 • 28 citations

A unifying concept for carcinogenic risk assessments

1983 • 26 citations

Determination of solanidine in human plasma by radioimmunoassay

1983 • 25 citations

Peroxidative in vitro metabolism of diethylstilbestrol induces formation of 8-hydroxy-2'-deoxyguanosine

1989 • 23 citations

A Unifying Concept for Carcinogenic Risk Assessments

1984 • 22 citations

Squamous-cell carcinoma and oral, pharyngeal and nasal lesions caused by foreign bodies in feed. Cases from a long-term study in rats

1989 • 20 citations

Towards Understanding Carcinogenic Hazards: A Crisis in Paradigms

1989 • 20 citations

Hypomethylation of ras oncogenes in chemically induced and spontaneous B6C3F1 mouse liver tumors.

1989 • 18 citations

Pre-existing, non-malignant disorders associated with increased cancer risk.

1980 • 9 citations

Chemically induced birth defects

1986 • 6 citations