Antimutagenesis in microbial systems

SPERMIDINE, SPERMINE, AND RELATED AMINES.

1964 • 547 citations

BASE-CHANGE MUTAGENESIS AND PROPHAGE INDUCTION IN STRAINS OF ESCHERICHIA COLI WITH DIFFERENT DNA REPAIR CAPACITIES

1970 • 405 citations

Studies on the Biochemical Basis of Spontaneous Mutation

1972 • 340 citations

MUTANTS OF YEAST DEFECTIVE IN MUTATION INDUCED BY ULTRAVIOLET LIGHT

1971 • 321 citations

Dominant Mutations ( lex ) in Escherichia coli K-12 Which Affect Radiation Sensitivity and Frequency of Ultraviolet Light-Induced Mutations

1972 • 310 citations

Time, Temperature, and Protein Synthesis: A Study of Ultraviolet-Induced Mutation in Bacteria

1956 • 307 citations

Ultraviolet reactivation and ultraviolet mutagenesis of λ in different genetic systems

1971 • 278 citations

ULTRAVIOLET-INDUCED MUTATION AND DNA REPAIR

1969 • 252 citations

Drugs which affect the Structure and Function of DNA

1968 • 229 citations

Thermal Enhancement of Ultraviolet Mutability in a tif-1 uvrA Derivative of Escherichia coli B/r: Evidence That Ultraviolet Mutagenesis Depends upon an Inducible Function

1974 • 219 citations

Spontaneous Mutation: Genetic Control of Mutation Rates in Bacteriophage T4

1969 • 206 citations

Studies on radiation-sensitive mutants of E. coli

1968 • 200 citations

ULTRAVIOLET‐INDUCED LETHALITY AND REVERSION TO PROTOTROPHY IN ESCHERICHIA COLI STRAINS WITH NORMAL AND REDUCED DARK REPAIR ABILITY

1965 • 180 citations

Modification of mutagenesis initiated by ultraviolet light through posttreatment of bacteria with basic dyes

1961 • 150 citations

Specificity and frequency of ultraviolet-induced reversion of an iso-1-cytochrome c ochre mutant in radiation-sensitive strains of yeast

1974 • 149 citations

The mutability toward ultarviolet light of recombination-deficient strains of Escherichia coli

1969 • 144 citations

Mutagenesis in Escherichia coli IV. Photosensitization to near ultraviolet light by 8-methoxypsoralen

1970 • 141 citations

THE BIOCHEMICAL ROLE OF NATURALLY OCCURRING POLYAMINES IN NUCLEIC ACID SYNTHESIS

1970 • 138 citations

Prophage induction and cell division in E. coli

1972 • 136 citations

Allelism tests of mutants affecting sensitivity to radiation in yeast and a proposed nomenclature

1971 • 125 citations

Ribosomal mutations affecting efficiency of amber suppression

1970 • 124 citations

Ultraviolet mutagenesis in polA and UvrA polA derivatives of Escherichia coli B-R: evidence for an inducible error-prone repair system.

1973 • 124 citations

EXPERIMENTS ON SPONTANEOUS AND CHEMICALLY INDUCED MUTATIONS OF BACTERIA GROWING IN THE CHEMOSTAT

1951 • 120 citations

Mutagenesis in Escherichia coli

1968 • 115 citations

Antimutagenic DNA Polymerases of Bacteriophage T4

1968 • 114 citations

The Interaction of Caffeine with Ultra-violet-light-irradiated DNA

1970 • 113 citations

Mechanism of Caffeine Enhancement of Mutations Induced by Sublethal Ultraviolet Dosages

1968 • 106 citations

On the darkreactivation mechanism in ultraviolet irradiated bacteria

1964 • 99 citations

Cytoplasmic and nuclear genetic events induced by UV light in strains of Saccharomyces cerevisiae with different UV sensitivites

1969 • 93 citations

Metabolism and Function of Spermine and Related Polyamines

1970 • 89 citations

Different modes of loss of photoreversibility of mutation and lethal damage in ultraviolet-light resistant and sensitive bacteria

1969 • 87 citations

TERMINAL SYNTHESIS OF XANTHOMMATIN IN DROSOPHILA MELANOGASTER. III. MUTATIONAL PLEIOTROPY AND PIGMENT GRANULE ASSOCIATION OF PHENOXAZINONE SYNTHETASE

1973 • 82 citations

THE EFFECT OF POSTTREATMENT WITH OHLORAMPHENICOL VARIOUS ULTRAVIOLET-INDUCED MUTATIONS IN ESCHERICHIA COLI

1960 • 76 citations

Suppression of Chemical Mutagenesis in Bacteriophage T4 by Genetically Modified DNA Polymerases

1970 • 76 citations

Effect of Gene Induction on the Rate of Mutagenesis by ICR-191 in Escherichia coli

1971 • 75 citations

Relation between repair mechanisms and induced mitotic recombination after UV irradiation, in the yeast Schizosaccharomyces pombe

1972 • 73 citations

Induction of forward mutations in mutationally defective yeast

1972 • 72 citations

Mutation in continuous cultures. I. Dependence of mutational response upon growth-limiting factors

1964 • 69 citations

PROPERTIES OF BACTERIOPHAGE T4 MUTANTS DEFECTIVE IN DNA POLYMERASE

1970 • 68 citations

Mutagenic and antimutagenic effects of acridine orange in Escherichia coli

1963 • 68 citations

INFLUENCE OF BACKGROUND GENOME ON ENZYMATIC CHARACTERISTICS OF YELLOW (Ay/-, Avy/-) MICE

1973 • 66 citations

Mutation and the repair of radiation damage in bacteria.

1966 • 65 citations

Mutagenic action during meiosis and antimutagenic action during mitosis by 5-aminoacridine in yeast

1964 • 64 citations

Four radiation sensitive mutants of Saccharomyces

1970 • 61 citations

Caffeine- and amino acid-effects upon try+ revertant yield in U.V.-irradiated hcr+ and hcr- mutants of E. coli B/r

1967 • 60 citations

Mapping of genes involved in the synthesis of spermidine in Escherichia coli

1972 • 59 citations

SOME BIOCHEMICAL ASPECTS OF THE POSTIRRADIATION MODIFICATION OF ULTRAVIOLET-INDUCED MUTATION FREQUENCY IN BACTERIA

1960 • 52 citations

INTERACTION OF STREPTOMYCIN AND A SUPPRESSOR FOR GALACTOSE FERMENTATION IN E. COLI K-12

1964 • 51 citations

Adriamycin and Daunorubicin Inhibition of Mutant T4 DNA Polymerases

1974 • 51 citations

“MUTATIONAL SYNERGISM” OF ULTRAVIOLET LIGHT AND CAFFEINE IN ESCHERICHIA COLI

1962 • 48 citations

Requirement for Protein Synthesis inrec-Dependent Repair of Deoxyribonucleic Acid inEscherichia coliafter Ultraviolet or X Irradiation

1972 • 48 citations

Effects of Mutations to Streptomycin Resistance on the Rate of Translation of Mutant Genetic Information

1966 • 47 citations

Dégradation par la cellule hôte du DNA du bactériophage lambda irradié par le rayonnement ultraviolet

1967 • 46 citations

On the effect of caffeine on mutation and recombination in Schizosaccharomyces pombe

1971 • 45 citations

Analysis of photoenzymatic repair of UV lesions in DNA by single light flashes VIII. Inhibition of photoenzymatic repair of UV lesions in E. coli DNA by caffeine

1970 • 45 citations

Effect of Quinacrine on X-Ray Sensitivity and the Repair of Damaged DNA in Escherichia coli K-12

1971 • 45 citations

Differential mutation of the beta-galactosidase gene of Escherichia coli.

1971 • 45 citations

REPAIR-MECHANISMS AND RADIATION-INDUCED MUTATIONS IN FISSION YEAST

1968 • 45 citations

Cell Division and Prophage Induction inEscherichia coli: Effects of Pantoyl Lactone and Various Furan Derivatives

1972 • 43 citations

Effect of spermidine on the activity of DNA polymerases

1972 • 43 citations

INDUCTION OF MUTATION IN CHLORAMPHENICOL-INHIBITED BACTERIA

1959 • 41 citations

Differential effects of caffeine in mutagen-treated Schizosaccharomyces pombe

1968 • 41 citations

Pathways of ultraviolet mutability in Saccharomyces cerevisiae☆☆☆I. Some properties of double mutants involving uvs9 and rev

1971 • 41 citations

Mutation to prototrophy in Escherichia coli K-12: Effect of broth on UV-induced mutation in strain AB1157 and four excision-deficient mutants

1972 • 40 citations

Pathways of ultraviolet mutability in Saccharomyces cerevisiae☆☆☆II. The effect of rev genes on recombination

1971 • 40 citations

On the mechanism of bromouracil-induced mutagenesis

1973 • 39 citations

The antimutagenic action of polyamines: suppression of the mutagenic action of an E. coli mutator gene and of 2-aminopurine.

1966 • 38 citations

STUDIES WITH MUTANTS BLOCKED IN THE SYNTHESIS OF POLYAMINES*

1970 • 38 citations

THE MUTAGENIC EFFECT OF 8-ETHOXYCAFFEIN, CAFFEIN AND DIMETHYLSULFATE IN THE OPHIOSTOMA BACK-MUTATION TEST

2010 • 36 citations

Mutation in continuous cultures

1964 • 36 citations

THE REVERSIBLE SUPPRESSION OF STATIONARY PHASE MUTATION IN ESCHERICHIA COLI BY CAFFEINE

1966 • 36 citations

MUTATIONAL SYNERGISM BETWEEN RADIATIONS AND METHYLATED PURINES IN ESCHERICHIA COLI

1964 • 31 citations

Induction of mutations in Saccharomyces cerevisiae by ultraviolet light

1969 • 31 citations

Induction of mutation by 5-fluorouracil and amino acid analogues in Ustilago maydis

1971 • 30 citations

Induced mutation in UV-sensitive mutants of Aspergillus nidulans and Neurospora crassa

1968 • 30 citations

Ultraviolet Mutagenesis in Strains of E. coli deficient in DNA Polymerase

1971 • 29 citations

Effects of the rec and exr mutations of Escherichia coli on UV reactivation of bacteriophage lambda damaged by different agents

1972 • 29 citations

Interactions of methylated acridines with DNA

1966 • 29 citations

The effect of a histidine operator-constitutive mutation on UV-induced mutability within the histidine operon ofSalmonella typhimurium

1972 • 28 citations

Evolution and Prevention of Drug-Resistance

1964 • 27 citations

Suppression by Methionine of Reversions to Adenine Independence in Schizosaccharomyces pombe

1963 • 27 citations

THE EFFECT OF ARABINOSE-SPECIFIC ENZYME SYNTHESIS ON RECOMBINATION IN THE ARABINOSE GENES OF ESCHERICHIA COLI

1967 • 26 citations

Prevention of the Emergence of Drug Resistance in Bacteria by Acridines, Phenothiazines, and Dibenzocycloheptenes

1966 • 25 citations

Genetic effects of caffeine

1974 • 25 citations

Su-II-specific restriction of amber suppression by mutation to streptomycin resistance

1968 • 24 citations

Mutagenic and antimutagenic effects of acridinium salts in yeast

1967 • 24 citations

Apparent Suppression of Mutation Rates in Bacteria by Spermine

1965 • 24 citations

Prevention of the emergence of antibiotic-resistant strains of bacteria by atabrine

1964 • 23 citations

Antimutagenic activity of actinomycin D and basic fuchsine in Saccharomyces cerevisiae

1968 • 23 citations

MUTATION RATES OF BACTERIA IN STEADY STATE POPULATIONS

1955 • 23 citations

The role of nutrient broth supplementation in UV mutagenesis of E. coli

1973 • 22 citations

A mutation in Escherichia coli enhancing the UV-mutability of phage λ but not of its infectious DNA in a spheroplast assay

1972 • 22 citations

Mutation and Recombination of Bacteriophage Lambda: Effect of Ultraviolet Radiation

1970 • 22 citations

Repair systems and nitrous acid mutagenesis in E. Coli B/r

1970 • 21 citations

Mutator activity in uvs mutants of Aspergillus nidulans

1972 • 21 citations

The influence of analogs of xanthine on the mutagenic effect of ultraviolet light

1968 • 20 citations

The induction of gene mutation and chromosome aberration inChlamydomonas eugametosby a phenylalanine analog

1969 • 20 citations

Prevention of the emergence of drug-resistant bacteria by polyamines

1962 • 20 citations

Relative susceptibilities of caffeine-sensitive and caffeine-resistant strains of Candida albicans to inactivation and mutation by ultraviolet radiation

1970 • 20 citations

On the identity of two bacterial mutator genes: effects of antimutagens

1969 • 19 citations

A case of mutagen specificity attributable to a plating medium effect

1962 • 19 citations

Do ultraviolet-induced mutations to steptomycin resistance exhibit susceptibility to mutation frequency decline?

1973 • 18 citations

The loss of phenotypic suppression in streptomycin-resistant mutants.

1967 • 17 citations

Effects of ethidium, quinacrine and hycanthone on survival and mutagenesis of UV-irradiated Hcr+ and Hcr- strains of E. Coli B/r.

1974 • 17 citations

Methionine as an antimutagen in Schizosaccharomyces pombe

1965 • 17 citations

Genes controlling ultraviolet mutability in yeast

1973 • 16 citations

EFFECT OF GENE INDUCTION ON FREQUENCY OF INTRAGENIC RECOMBINATION OF CHROMOSOME AND F-MEROGENOTE IN ESCHERICHIA COLI K-12

1968 • 16 citations

Ultraviolet mutagenesis in repair-deficient derivatives of Escherichia coli B/r: uvrA uvrB and uvrA recC strains

1972 • 15 citations

Effect of the recC gene in Escherichia coli on frequencies of ultraviolet-induced mutants

1973 • 15 citations

Bacterial genetic factors controlling the suppression of T4 phage Amber mutants

1968 • 15 citations

Synergistic effect of an Escherichiacoli mutator gene on mutagenesis by ultraviolet radiation and by alkylating agents

1972 • 14 citations

Effect of caffeine on the recombination process of Bacillus subtilis

1972 • 14 citations

UV-induced reversion to prototrophy in three strains of Chlamydomonas reinhardi differing in dark repair capacity

1968 • 14 citations

Effects of liquid holding on the induction of mutations in an ultraviolet-sensitive strain of Aspergillus nidulans

1969 • 14 citations

Einfluß von Coffein auf die Reparatur von UV-Prämutationen bei der phr−-Mutante von E. coli

1968 • 13 citations

Gene-controlled change in mutational stability of a tryptophanless mutant of E. coli WP2

1967 • 12 citations

MODIFICATION BY MANGANOUS CHLORIDE OF THE FREQUENCY OF MUTATION INDUCED BY NITROGEN MUSTARD

1962 • 12 citations

Mutagenicity of amino acid analogues in eukaryotes

1974 • 12 citations

Modification of Lethality and Mutagenesis by Growth Inhibition of Ultraviolet-irradiated Escherichia coli strain B/R

1968 • 11 citations

The influence of the cytoplasm on mutation in Aspergillus nidulans

1966 • 10 citations

Effect of Purine and Pyrimidine Analogues on Reversion of a Tryptophan-requiring Strain of Escherichia coli

1959 • 10 citations

THE RELATIONSHIP BETWEEN RECOMBINATION AND TRANSCRIPTION OF THE LACTOSE GENES OF ESCHERICHIA COLI K-12

1967 • 10 citations

Mutational and dark-repair specificities in U.V.-irradiated di-auxotrophs of E. coli B/r

1967 • 10 citations

In vitro characterization of a mutator T4 DNA polymerase.

1973 • 10 citations

A difference in the photoreactivation of UV-damage between genes in the repressed and genes in the de-repressed state

1965 • 10 citations

Genetic influence on the back-mutation rate in biochemical mutant strains of Ophiostoma

1962 • 9 citations

Pre- and Post-irradiation Effects upon Lethality and Reversion in Salmonella typhimurium

1971 • 9 citations

Prevention of Antibiotic Resistance in Vitro in Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa by Coumadin

1971 • 9 citations

DIFFERENTIAL MUTABILITIES TO TYPES OF MUTATIONS WITH ULTRAVIOLET LIGHT BETWEEN NORMAL AND UV-SENSITIVE MUTANT OF YEAST

1969 • 9 citations

Purification and Properties of Two Growth Stage-dependent Deoxyribonucleic Acid Polymerases from Lactobacillus acidophilus

1973 • 8 citations

Postirradiation Protein Synthesis and the Inductions of Cytoplasmic and Genic Mutations in <i>Saccharomyces</i> by Ultraviolet Radiation

1963 • 8 citations

Analysis of an apparent case of “gene-controlled mutational stability”: The auxotrophic preemption of a specific growth requirement

1969 • 8 citations

Utilization of aminopurine deoxynucleoside triphosphate by mutator, antimutator and wild-type DNA polymerases of bacteriophage T4.

1973 • 8 citations

Ethidium bromide inhibition of dark repair processes in ultraviolet- irradiated T$sub 1$ bacteriophage and bacteria

1973 • 8 citations

Population dynamics and results of fluctuation tests in a study of the role of Atabrine as an antimutagen in preventing streptomycin resistance in Staphylococcus aureus.

1966 • 7 citations

The dependence of UV-induced reversions to prototrophy on the streptomycin resistance allele in Escherichia coli

1973 • 7 citations

REACTIVATION BY MANGANOUS CHLORIDE OF SPORES INACTIVATED BY NITROGEN MUSTARD

1959 • 7 citations

The effect of the plating medium on the recovery of nonsense suppressors in Saccharomyces cerevisiae

1973 • 6 citations

A HISTIDINE OPERATOR-CONSTITUTIVE MUTATION DECREASES THE FREQUENCY OF RECOMBINATION WITHIN THE HISTIDINE OPERON OF SALMONELLA TYPHIMURIUM

1972 • 5 citations

Influence of streptomycin on UV-induced TRP+ reversions in a streptomycin-resistant strain of E. Coli B/R

1973 • 5 citations

Antimutagens and Antimicrobial Drug Resistance

1971 • 5 citations

Effect of the nutritional environment on the development of resistance to polymyxin B in Pseudomonas aeruginosa and its prevention by atabrine.

1968 • 4 citations

Effects of mutator, antimutator and wild-type DNA polymerase of T4 bacteriophage on mutation rates in rII cistrons of its own genome and in complemented amber mutants of gene 43.

1974 • 3 citations

Atabrine as an Adjuvant in Chemotherapy of Urinary Tract Infections

1970 • 3 citations

Interaction of manganous ions with DNA repair after uv irradiation in Proteus mirabilis

1973 • 2 citations

LETTERS TO THE EDITOR: AN ALTERNATIVE INTERPRETATION OF ULTRAVIOLET MUTAGENESIS

1973 • 2 citations