Effects of indole-3-carbinol on lung tumorigenesis and DNA methylation induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and on the metabolism and disposition of NNK in A/J mice.

A procedure for the isolation of deoxyribonucleic acid from micro-organisms

1961 • 11,554 citations

Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke

1988 • 689 citations

Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles.

1978 • 432 citations

Nicotine-derived N-nitrosamines and tobacco-related cancer: current status and future directions.

1985 • 332 citations

Glutathione <italic>S</italic>-Transferase Activity: Enhancement by Compounds Inhibiting Chemical Carcinogenesis and by Dietary Constituents<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1982 • 325 citations

Induction of lung and exocrine pancreas tumors in F344 rats by tobacco-specific and Areca-derived N-nitrosamines.

1988 • 306 citations

Aryl Hydrocarbon Hydroxylase Induction in Rat Tissues by Naturally Occurring Indoles of Cruciferous Plants<xref ref-type="fn" rid="fn2">2</xref>

1975 • 246 citations

Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation and tumorigenicity in the lung of F344 rats by dietary phenethyl isothiocyanate.

1989 • 197 citations

Effects of aromatic isothiocyanates on tumorigenicity, O6-methylguanine formation, and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung.

1989 • 184 citations

Rapid single-dose model for lung tumor induction in A/J mice by 4-(methylnitrosainino)-1-(3-pyridyl)-1-butanone and the effect of diet

1989 • 132 citations

Effect of dietary indole-3-carbinol on intestinal and hepatic monooxygenase, glutathione S-transferase and epoxide hydrolase activities in the rat

1984 • 130 citations

Inhibition of aflatoxin B¹ carcinogenesis in rainbow trout by flavone and indole compounds

1984 • 121 citations

Effects of alkyl chain length on the inhibition of NNK-induced lung neoplasia in A/J mice by arylalkyl isothiocyanates

1989 • 112 citations

Accumulation and persistence of DNA adducts in respiratory tissue of rats following multiple administrations of the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone.

1986 • 107 citations

Enhancement of carcinogenesis by the natural anticarcinogen indole-3-carbinol.

1987 • 105 citations

Quantitative inter-relationships between aflatoxin B1 carcinogen dose, indole-3-carbinol anti-carcinogen dose, target organ DNA adduction and final tumor response

1989 • 101 citations

Multiple dietary factors in the enhancement of dimethylhydrazine carcinogenesis: main effect of indole-3-carbinol.

1986 • 93 citations

Effects of dietary indoles and isothiocyanates on N-nitrosodimethylamine and 4-(methylnitrosamino)-1-(3-pyridyl)- 1-butanone α-hydroxylation and DNA methylation in rat liver

1985 • 88 citations

Cell selective alkylation of DNA in rat lung following low dose exposure to the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone.

1987 • 81 citations

Mechanisms of anti-carcinogenesis by indole-3-carbinol

1990 • 69 citations

Strain a Mouse Lung Tumor Bioassay

1982 • 62 citations

Effects of dietary compounds on alpha-hydroxylation of N-nitrosopyrrolidine and N'-nitrosonornicotine in rat target tissues.

1984 • 59 citations

Indole-3-carbinol protects against covalent binding of benzo[a]pyrene and N-nitrosodimethylamine metabolites to mouse liver macromolecules

1984 • 54 citations

Effects of dietary sinigrin or indole-3-carbinol on O⁶-methylguanine-DNA-transmethylase activity and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA methylation and tumorigenicity in F344 rats

1988 • 43 citations

The Metabolic Formation of γ-(3-Pyridyl)-γ-hydroxybutyric Acid and Its Possible Intermediary Role in the Mammalian Metabolism of Nicotine

1964 • 37 citations

Comparison of two routes of chemical administration on the lung adenoma response in strain AJ mice

1986 • 36 citations

Species- and length of exposure-dependent differences in the benzo(a)pyrene:DNA adducts formed in embryo cell cultures from mice, rats, and hamsters.

1985 • 29 citations