Identification of an additional gene required for eukaryotic nonsense mRNA turnover.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Experiments in molecular genetics

1972 • 28,260 citations

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformaion of Escherichia coli

1987 • 2,493 citations

Nuclear targeting sequences — a consensus?

1991 • 1,908 citations

Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: Identification of a class of bipartite nuclear targeting sequence

1991 • 1,501 citations

A simple method for site-directed mutagenesis using the polymerase chain reaction

1989 • 607 citations

The poly(A) binding protein is required for poly(A) shortening and 60S ribosomal subunit-dependent translation initiation

1989 • 561 citations

Regulation of the Yeast HO Gene

1985 • 526 citations

Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript.

1994 • 511 citations

The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon.

1991 • 487 citations

mRNA surveillance by the Caenorhabditis elegans smg genes.

1993 • 459 citations

Premature translational termination triggers mRNA decapping

1994 • 399 citations

Gene products that promote mRNA turnover in Saccharomyces cerevisiae.

1992 • 330 citations

mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor.

1993 • 307 citations

Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon.

1995 • 279 citations

Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen.

1995 • 278 citations

A new kind of informational suppression in the nematode Caenorhabditis elegans.

1989 • 272 citations

Temperature-sensitive Yeast Mutant Defective in Ribonucleic Acid Production

1969 • 201 citations

Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA.

1993 • 179 citations

The yeast homolog to mouse Tcp-1 affects microtubule-mediated processes.

1991 • 175 citations

Physical map of the Saccharomyces cerevisiae genome at 110-kilobase resolution.

1991 • 156 citations

Gene Products That Promote mRNA Turnover in Saccharomyces cerevisiae

1992 • 132 citations

The majority of yeast UPF1 co-localizes with polyribosomes in the cytoplasm.

1995 • 132 citations

Beta-globin nonsense mutation: deficient accumulation of mRNA occurs despite normal cytoplasmic stability.

1992 • 124 citations

Suppressible Four-Base Glycine and Proline Codons in Yeast

1981 • 49 citations

The Yeast Homolog to Mouse Tcp-1 Affects Microtubule-Mediated Processes†

1991 • 47 citations

FRAMESHIFT SUPPRESSION IN SACCHAROMYCES CEREVISIAE. IV. NEW SUPPRESSORS AMONG SPONTANEOUS CO-REVERTANTS OF THE GROUP II HIS4-206 AND LEU2-3 FRAMESHIFT MUTATIONS

1982 • 40 citations