The role of adrenocorticoids as modulators of immune function in health and disease: neural, endocrine and immune interactions

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Précis ofThe neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system

1982 • 4,511 citations

A Syndrome produced by Diverse Nocuous Agents

1936 • 3,733 citations

Stress and the Individual

1993 • 3,458 citations

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

Resilience in the Face of Adversity

1985 • 3,283 citations

Physiological Functions of Glucocorticoids in Stress and Their Relation to Pharmacological Actions*

1984 • 3,073 citations

Biology of Natural Killer Cells

1989 • 2,970 citations

Two Receptor Systems for Corticosterone in Rat Brain: Microdistribution and Differential Occupation

1985 • 2,530 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

EFFECT OF PSYCHOSOCIAL TREATMENT ON SURVIVAL OF PATIENTS WITH METASTATIC BREAST CANCER

1989 • 2,377 citations

Interleukin-10

1993 • 1,820 citations

The Role of the Hippocampus in Feedback Regulation of the Hypothalamic-Pituitary-Adrenocortical Axis*

1991 • 1,690 citations

Psychological Stress and Susceptibility to the Common Cold

1991 • 1,679 citations

Mineralocorticoid Action: Target Tissue Specificity Is Enzyme, Not Receptor, Mediated

1988 • 1,607 citations

Immune Response in Mice that Lack the Interferon-γ Receptor

1993 • 1,570 citations

Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones

1986 • 1,521 citations

Interleukin-1 Stimulates the Secretion of Hypothalamic Corticotropin-Releasing Factor

1987 • 1,512 citations

Immune-Neuro-Endocrine Interactions: Facts and Hypotheses

1996 • 1,477 citations

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

A TH1→TH2 switch is a critical step in the etiology of HIV infection

1993 • 1,403 citations

Circadian variation and triggers of onset of acute cardiovascular disease.

1989 • 1,400 citations

Malignant Melanoma

1979 • 1,323 citations

Lymphokine Control of In Vivo Immunoglobulin Isotype Selection

1990 • 1,303 citations

Corticosteroid Inhibition of ACTH Secretion*

1984 • 1,212 citations

Two functional components of the hippocampal memory system

1994 • 1,114 citations

Effect of Neonatal Handling on Age-Related Impairments Associated with the Hippocampus

1988 • 1,068 citations

Malignant Melanoma

1993 • 1,050 citations

Corticosteroids and Lymphoid Cells

1972 • 1,030 citations

Diabetes in identical twins

1981 • 965 citations

DEPRESSED LYMPHOCYTE FUNCTION AFTER BEREAVEMENT

1977 • 949 citations

Aggression, suicide, and serotonin: relationships to CSF amine metabolites

1982 • 915 citations

Corticosteroid‐Mediated Immunoregulation in Man

1982 • 902 citations

Hypothalamic Control of Adrenocorticotropin Secretion: Advances since the Discovery of 41-Residue Corticotropin-Releasing Factor

1986 • 874 citations

Psychosocial Modifiers of Immunocompetence in Medical Students

1984 • 793 citations

Superantigens: Mechanism of T-Cell Stimulation and Role in Immune Responses

1991 • 783 citations

The Serum Transport of Steroid Hormones

1982 • 777 citations

Psychoneuroendocrine Influences on Immunocompetence and Neoplasia

1981 • 763 citations

Chemical and Anatomical Plasticity of Brain

1964 • 757 citations

A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1.

1992 • 727 citations

Inflammatory mediator-induced hypothalamic-pituitary-adrenal axis activation is defective in streptococcal cell wall arthritis-susceptible Lewis rats.

1989 • 723 citations

Effects of stress on immune cell distribution. Dynamics and hormonal mechanisms.

1995 • 719 citations

Evolution of the Stress Concept

2020 • 713 citations

Stress and infectious disease in humans.

1991 • 683 citations

Cytotoxic T-cell memory without antigen

1994 • 669 citations

Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders.

1996 • 653 citations

Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 appearance during lethal bacteremia.

1989 • 651 citations

Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism.

1990 • 629 citations

LEUKOKINETIC STUDIES. IV. THE TOTAL BLOOD, CIRCULATING AND MARGINAL GRANULOCYTE POOLS AND THE GRANULOCYTE TURNOVER RATE IN NORMAL SUBJECTS*

1961 • 626 citations

Opioid Peptides Mediate the Suppressive Effect of Stress on Natural Killer Cell Cytotoxicity

1984 • 611 citations

The Effect of In Vivo Hydrocortisone on Subpopulations of Human Lymphocytes

1974 • 607 citations

A central nervous system defect in biosynthesis of corticotropin-releasing hormone is associated with susceptibility to streptococcal cell wall-induced arthritis in Lewis rats.

1989 • 579 citations

The neuronal mineralocorticoid eeceptor as a mediator of glucocorticoid response

1988 • 576 citations

Glucocorticoid-induced inhibition of T cell growth factor production. I. The effect on mitogen-induced lymphocyte proliferation.

1979 • 567 citations

The Functions of Corticosteroid-Binding Globulin and Sex Hormone-Binding Globulin: Recent Advances*

1990 • 559 citations

The Virology and Immunobiology of Lymphocytic Choriomeningitis Virus Infection

1980 • 554 citations

Stress and the individual. Mechanisms leading to disease

1993 • 522 citations

Stress, loneliness, and changes in herpesvirus latency

1985 • 500 citations

Inhibition of Granulocyte Adherence by Ethanol, Prednisone, and Aspirin, Measured with an Assay System

1974 • 496 citations

Autocrine or Paracrine Inflammatory Actions of Corticotropin-Releasing Hormone in Vivo

1991 • 485 citations

Endothelial cell binding of NAP-1/IL-8: role in neutrophil emigration

1992 • 477 citations

Stress-induced changes in blood leukocyte distribution. Role of adrenal steroid hormones.

1996 • 472 citations

The Stress Response and the Regulation of Inflammatory Disease

1992 • 469 citations

The Role of Inheritance in Behavior

1990 • 455 citations

Stress-Induced Modulation of the Immune Response

1977 • 449 citations

Stress-induced enhancement of antigen-specific cell-mediated immunity.

1996 • 421 citations

Modulation of cellular immunity in medical students

1986 • 418 citations

Network of immune-neuroendocrine interactions.

1977 • 413 citations

Proteoglycans on endothelial cells present adhesion-inducing cytokines to leukocytes

1993 • 412 citations

Biochemistry, Molecular Biology, and Physiology of the Glucocorticoid Receptor*

1987 • 409 citations

Regulation of the in vitro antibody response by neuroendocrine hormones

1982 • 405 citations

Dexamethasone-mediated inhibition of human T cell growth factor and gamma-interferon messenger RNA.

1984 • 390 citations

Stress-Induced Suppression of Immunity in Adrenalectomized Rats

1983 • 390 citations

Stress-related immune suppression: Health implications

1987 • 389 citations

Experimental basis for neural-immune interactions

1995 • 386 citations

Nonhuman primate model of alcohol abuse: effects of early experience, personality, and stress on alcohol consumption.

1991 • 375 citations

Contrasting effects of glucocorticoids on the capacity of T cells to produce the growth factors interleukin 2 and interleukin 4

1989 • 372 citations

Interactions between the Neuroendocrine and Immune Systems: Common Hormones and Receptors

1987 • 371 citations

Alcohol and Central Serotonin Metabolism in Man

1979 • 368 citations

Stress and cancer.

1981 • 367 citations

Intracellular Receptor Concentration Limits Glucocorticoid-Dependent Enhancer Activity*

1987 • 363 citations

ACADEMIC STRESS, POWER MOTIVATION, AND DECREASE IN SECRETION RATE OF SALIVARY SECRETORY IMMUNOGLOBULIN A

1983 • 360 citations

Short Papers

1977 • 360 citations

Less Mortality but More Relapses in Experimental Allergic Encephalomyelitis in CD8 ^-/- Mice

1992 • 359 citations

Suppression of Immunity by Stress: Effect of a Graded Series of Stressors on Lymphocyte Stimulation in the Rat

1981 • 354 citations

Role of CD8 ⁺ T Cells in Murine Experimental Allergic Encephalomyelitis

1992 • 351 citations

Regulation of murine lymphokine production in vivo. III. The lymphoid tissue microenvironment exerts regulatory influences over T helper cell function.

1990 • 349 citations

Mechanisms of corticosteroid action on lymphocyte subpopulations. I. Redistribution of circulating T and b lymphocytes to the bone marrow.

1975 • 345 citations

Changes in Blood Hormone Levels during the Immune Response

1975 • 342 citations

Cellular events in the lymph node and lung of mice with influenza. Consequences of depleting CD4+ T cells.

1990 • 340 citations

Emotional, behavioral, and physiological effects of chronic stress at Three Mile Island.

1983 • 332 citations

Sympathetic innervation of murine thymus and spleen: Evidence for a functional link between the nervous and immune systems

1981 • 325 citations

Programmed T lymphocyte death. Cell activation- and steroid-induced pathways are mutually antagonistic.

1990 • 319 citations

Murine NK cell cultures: effects of interleukin-2 and interferon on cell growth and cytotoxic reactivity.

1981 • 317 citations

Activation of T lymphocytes in dengue virus infections. High levels of soluble interleukin 2 receptor, soluble CD4, soluble CD8, interleukin 2, and interferon-gamma in sera of children with dengue.

1991 • 310 citations

Comparison of agents producing a neutrophilic leukocytosis in man. Hydrocortisone, prednisone, endotoxin, and etiocholanolone.

1975 • 310 citations

Human lymphocyte subpopulations. Effect of corticosteroids.

1974 • 307 citations

Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes.

1994 • 305 citations

Alternate-Day Prednisone

1974 • 298 citations

Cytotoxic cells induced during lymphocytic choriomeningitis virus infection of mice. I. Characterization of natural killer cell induction

1978 • 296 citations

Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor.

1988 • 295 citations

Stress response, adrenal steroid receptor levels and corticosteroid-binding globulin levels — a comparison between Sprague-Dawley, Fischer 344 and Lewis rats

1993 • 294 citations

Cytokines as modulators of the hypothalamus-pituitary-adrenal axis

1991 • 289 citations

Hormones, peripherally activated prohormones and regulation of the Th1/Th2 balance

1994 • 286 citations

Natural killer (NK) cell activity in the rat. I. Isolation and characterization of the effector cells.

1981 • 284 citations

Perturbing the organism: the biology of stressful experience

1993 • 283 citations

Stress and cancer.

1981 • 282 citations

The Periaqueductal Gray Matter Mediates Opiate-Induced Immunosuppression

1989 • 280 citations

Direct evidence for the role of LGL in the inhibition of experimental tumor metastases.

1985 • 279 citations

Possible Connections between Stress, Diabetes, Obesity, Hypertension and Altered Lipoprotein Metabolism that may Result in Atherosclerosis

1989 • 275 citations

Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor.

1995 • 272 citations

Effects of Corticosteroid Therapy on Human Monocyte Function

1975 • 268 citations

Virus-Induced Corticosterone in Hypophysectomized Mice: A Possible Lymphoid Adrenal Axis

1982 • 266 citations

Susceptibility Rhythm to E. coli Endotoxin and Bioassay.

1960 • 263 citations

In vivo biologic and immunohistochemical analysis of interleukin-1 alpha, beta and tumor necrosis factor during experimental endotoxemia. Kinetics, Kupffer cell expression, and glucocorticoid effects.

1991 • 262 citations

Immunological changes in young and old adults during brief laboratory stress.

1991 • 262 citations

Coexpression of T4 and T8 on peripheral blood T cells demonstrated by two-color fluorescence flow cytometry.

1985 • 261 citations

Genetic variation in the stress response: susceptibility to experimental allergic encephalomyelitis and implications for human inflammatory disease

1991 • 254 citations

Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype.

1991 • 254 citations

THE EFFECT OF GLUCOCORTICOSTEROIDS ON THE KINETICS OF MONONUCLEAR PHAGOCYTES

1970 • 252 citations

Diurnal and Acute Stress-Induced Changes in Distribution of Peripheral Blood Leukocyte Subpopulations

1994 • 250 citations

Tumor Rejection in Rats After Inescapable or Escapable Shock

1982 • 249 citations

Glucocorticoid receptor-mediated suppression of the interleukin 2 gene expression through impairment of the cooperativity between nuclear factor of activated T cells and AP-1 enhancer elements.

1992 • 246 citations

Glucocorticoids and Immune Function

1991 • 245 citations

Glucocorticoid-induced inhibition of T cell growth factor production. II. The effect on the in vitro generation of cytolytic T cells.

1979 • 244 citations

Stress increases metastatic spread of a mammary tumor in rats: Evidence for mediation by the immune system

1991 • 244 citations

Studies on the bioperiodicity of the immune response. I. Circadian rhythms of human T, B, and K cell traffic in the peripheral blood.

1981 • 242 citations

Stress depresses interferon production by leukocytes concomitant with a decrease in natural killer cell activity.

1986 • 241 citations

Perceived social support and tumor estrogen/progesterone receptor status as predictors of natural killer cell activity in breast cancer patients.

1990 • 241 citations

Adrenal steroid type I and type II receptor binding: estimates of in vivo receptor number, occupancy, and activation with varying level of steroid

1990 • 238 citations

A kinetic study of immune mediators in the lungs of mice infected with influenza A virus.

1992 • 238 citations

Functional analysis of T lymphocyte subsets in antiviral host defense.

1987 • 237 citations

Premorbid psychological factors as related to cancer incidence

1978 • 235 citations

T-cell-mediated immunopathology versus direct cytolysis by virus: implications for HIV and AIDS

1994 • 235 citations

The effect of Hydrocortisone on the kinetics of normal human lymphocytes

1975 • 234 citations

Effects of IL-12 on the response and susceptibility to experimental viral infections.

1994 • 233 citations

A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3E gene.

1994 • 233 citations

Stress and Antibody Response in Rats

1969 • 233 citations

Effects of coping behavior with and without a feedback signal on stress pathology in rats.

1971 • 230 citations

Interactions between Tumor Necrosis Factor-α, Hypothalamic Corticotropin-Releasing Hormone, and Adrenocorticotropin Secretion in the Rat*

1990 • 227 citations

Stress and Immune Function in Humans

1991 • 224 citations

Activation of the glucocorticoid-receptor complex

1982 • 224 citations

Paradoxical effects of adrenal steroids on the brain: Protection versus degeneration

1992 • 222 citations

Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids.

1995 • 215 citations

Effect of chronic stress and exogenous glucocorticoids on regional fat distribution and metabolism

1992 • 214 citations

CD4+ subset regulation in viral infection. Preferential activation of Th2 cells during progression of retrovirus-induced immunodeficiency in mice.

1992 • 213 citations

Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT.

1993 • 211 citations

Therapeutic concentrations of glucocorticoids suppress the antimicrobial activity of human macrophages without impairing their responsiveness to gamma interferon.

1985 • 206 citations

Predominance of Th1 cells in ocular tissues during herpetic stromal keratitis.

1992 • 202 citations

An assessment of the effects of glucocorticoids on degranulation, chemotaxis, binding to vascular endothelium and formation of leukotriene B4 by purified human neutrophils.

1989 • 202 citations

Rescue of thymocytes and T cell hybridomas from glucocorticoid‐induced apoptosis by stimulation via the T cell receptor/CD3 complex: a possible in vitro model for positive selection of the T cell repertoire

1991 • 199 citations

Stress depresses interferon production by leukocytes concomitant with a decrease in natural killer cell activity.

1986 • 197 citations

In vitro alteration of receptors for vasoactive intestinal peptide changes the in vivo localization of mouse T cells.

1984 • 189 citations

Stress, opioid peptides, the immune system, and cancer

1985 • 188 citations

Characterization of Rat Brain Aldosterone Receptors Reveals High Affinity for Corticosterone

1983 • 188 citations

Cytokines in the generation of immune responses to, and resolution of, virus infection

1994 • 185 citations

Protection against acute lethal viral infections with the native steroid dehydroepiandrosterone (DHEA)

1988 • 183 citations

Steroid Hormone Receptors and the Nucleus*

1985 • 181 citations

Endogenous glucocorticoids restrain catecholamine synthesis and release at rest and during immobilization stress in rats.

1993 • 180 citations

Timing of surgery during menstrual cycle and survival of premenopausal women with operable breast cancer

1991 • 179 citations

Alternate-day prednisone therapy and human lymphocyte subpopulations.

1975 • 179 citations

How corticosteroids work*1, *2

1975 • 177 citations

Endogenous cortisol: A regulator of the number of lymphocytes in peripheral blood

1980 • 175 citations

Glucocorticoids increase the synthesis of immunoglobulin E by interleukin 4-stimulated human lymphocytes.

1991 • 174 citations

Effect of sport stress on lymphocyte transformation and antibody formation.

1978 • 173 citations

Immunosuppression by Glucocorticoids: Inhibition of Production of Multiple Lymphokines by in Vivo Administration of Dexamethasone

1993 • 173 citations

Restraint stress differentially affects anti-viral cellular and humoral immune responses in mice

1991 • 171 citations

Thymus-Derived Lymphocytes Sequestered in the Bone Marrow of Hydrocortisone-Treated Mice

1972 • 171 citations

Mechanisms of corticosteroid action on lymphocyte subpopulations

1979 • 168 citations

Hydrocortisne resistance of graft vs host activity in mouse thymus, spleen and bone marrow.

1970 • 165 citations

IL-4 and IL-2 selectively rescue Th cell subsets from glucocorticoid-induced apoptosis.

1992 • 165 citations

Negative regulation of interleukin 2 transcription by the glucocorticoid receptor.

1992 • 164 citations

Glucocorticoid-mediated control of the activation and clonal deletion of peripheral T cells in vivo.

1993 • 163 citations

In search of an emotional system in the brain: Leaping from fear to emotion and consciousness.

1995 • 160 citations

Chronic social stress produces reductions in available splenic type II corticosteroid receptor binding and plasma corticosteroid binding globulin levels

1996 • 155 citations

Stressor exposure and immunological response in man: Interferon-producing capacity and phagocytosis

1976 • 154 citations

Human Lymphocyte Subpopulations

1978 • 154 citations

Inhibition of eicosanoid biosynthesis by glucocorticoids in humans.

1990 • 152 citations

Glucocorticoid inhibition of lymphokine secretion by alloreactive T lymphocyte clones.

1984 • 150 citations

Intracerebroventricular infusion of interleukin 1 rapidly decreases peripheral cellular immune responses.

1989 • 150 citations

Human gamma interferon increases the binding of T lymphocytes to endothelial cells.

1985 • 148 citations

Programmed cell death of T lymphocytes during acute viral infection: a mechanism for virus-induced immune deficiency

1993 • 147 citations

Cellular immunity after intravenous administration of methylprednisolone.

1974 • 147 citations

Evidence that shock-induced immune suppression is mediated by adrenal hormones and peripheral β-adrenergic receptors

1990 • 146 citations

Expression of interleukin 2, interferon-gamma, and the IL 2 receptor by human peripheral blood lymphocytes.

1986 • 143 citations

Mechanisms of stress-induced modulation of viral pathogenesis and immunity

1993 • 142 citations

Central Corticotropin-Releasing Factor Mediates the Suppressive Effect of Stress on Natural Killer Cytotoxicity*

1990 • 141 citations

Virus infection as a stressor: Influenza virus elevates plasma concentrations of corticosterone, and brain concentrations of MHPG and tryptophan

1989 • 141 citations

Mechanism of Surgical Stress Impairment of Human Perioperative Natural Killer Cell Cytotoxicity

1991 • 141 citations

Cloned suppressor T cells from a lepromatous leprosy patient suppress Mycobacterium leprae reactive helper T cells

1986 • 140 citations

Glucocorticoids suppress the production of interleukin 4 by human lymphocytes

1991 • 140 citations

Norepinephrine and the antibody response.

1985 • 139 citations

Adrenal steroid receptor activation in rat brain and pituitary following dexamethasone: Implications for the dexamethasone suppression test

1992 • 139 citations

Regulation of neutrophil-derived IL-8: the role of prostaglandin E2, dexamethasone, and IL-4.

1993 • 137 citations

The role of T cells in anti-herpes simplex virus immunity. I. Induction of antigen-specific cytotoxic T lymphocytes.

1977 • 136 citations

THE EFFECT OF GLUCOCORTICOSTEROIDS ON THE PROLIFERATION AND KINETICS OF PROMONOCYTES AND MONOCYTES OF THE BONE MARROW

1973 • 136 citations

Stress-induced suppression of herpes simplex virus (HSV)-specific cytotoxic T lymphocyte and natural killer cell activity and enhancement of acute pathogenesis following local HSV infection

1991 • 135 citations

Concurrent production of interleukin-2, interleukin-10, and gamma interferon in the regional lymph nodes of mice with influenza pneumonia

1994 • 134 citations

Regulation of transforming growth factor-beta 1 gene expression by glucocorticoids in normal human T lymphocytes.

1991 • 133 citations

Experimental Models for Understanding B Lymphocyte Formation

1987 • 132 citations

Intracerebral cytokine mRNA expression during fatal and nonfatal alphavirus encephalitis suggests a predominant type 2 T cell response.

1994 • 132 citations

Increased Susceptibility to Herpes Simplex in Mice Subjected to Avoidance-Learning Stress or Restraint.

1957 • 130 citations

Inhibition by cortisol of human natural killer (NK) cell activity

1987 • 130 citations

The Affect of Hopelessness and the Development of Cancer

1966 • 129 citations

Central nervous system influences on lymphocyte migration

1992 • 128 citations

Thymocyte apoptosis induced by elevated endogenous corticosterone levels

1994 • 126 citations

Diurnal differences in basal and acute stress levels of type I and type II adrenal steroid receptor activation in neural and immune tissues.

1993 • 126 citations

Accumulation of adoptively transferred adherent, lymphokine-activated killer cells in murine metastases.

1991 • 124 citations

Evidence for the role of natural immunity in the control of metastatic spread of head and neck cancer

1987 • 123 citations

Direct suppression of natural killer activity in human peripheral blood leukocyte cultures by glucocorticoids and its modulation by interferon.

1983 • 121 citations

Cytolytic T Lymphocytes

1983 • 119 citations

Studies of the bioperiodicity of the immune response. II. Co-variations of murine T and B cells and a role of corticosteroid.

1981 • 118 citations

The Swedish childhood diabetes study: indications of severe psychological stress as a risk factor for Type 1 (insulin-dependent) diabetes mellitus in childhood

1991 • 117 citations

Differential activation of adrenal steroid receptors in neural and immune tissues of Sprague Dawley, Fischer 344, and Lewis rats

1995 • 116 citations

Stress and Immune Responses III. Effect of Restraint Stress on Delayed Type Hypersensitivity (DTH) Response, Natural Killer (NK) Activity and Phagocytosis in Mice

1986 • 114 citations

Circadian rhythmicity of human plasma cortisol and PHA-induced lymphocyte transformation.

1975 • 114 citations

A MAP OF BLOOD AND URINARY CHANGES RELATED TO CIRCADIAN VARIATIONS IN ADRENAL CORTICAL FUNCTION IN NORMAL SUBJECTS

1962 • 110 citations

THE REVERSIBILITY OF CERTAIN RHEUMATIC AND NONRHEUMATIC CONDITIONS BY THE USE OF CORTISONE OR OF THE PITUITARY ADRENOCORTICOTROPIC HORMONE

1952 • 109 citations

Review of the effects of stress on cancer in laboratory animals: Importance of time of stress application and type of tumor.

1985 • 109 citations

The migration of lymphocytes across specialized vascular endothelium

1982 • 108 citations

Sex and strain differences in the circadian rhythm fluctuation of endocrine and immune function in the rat: implications for rodent models of autoimmune disease

1991 • 108 citations

Inhibition of O2- generation by dexamethasone is mimicked by lipocortin I in alveolar macrophages.

1989 • 108 citations

Interferon induces peripheral lymphadenopathy in mice.

1981 • 107 citations

CHANGES IN CONNECTIVE TISSUE REACTION INDUCED BY CORTISONE

1952 • 105 citations

Cerebral expression of multiple cytokine genes in mice with lymphocytic choriomeningitis.

1994 • 103 citations

Surgical stress impairs natural killer cell programming of tumor for lysis in patients with sarcomas and other solid tumors

1992 • 102 citations

Interleukin 2-induced proliferation of murine natural killer cells in vivo.

1990 • 102 citations

Immunosuppressive and Anti-Inflammatory Effects of Glucocorticoids

1979 • 101 citations

Enhancement of Antigen-Specific Humoral and Cell-Mediated Immunity by Electric Footshock Stress in Rats

1993 • 99 citations

Influence of stressor predictability and behavioral control on lymphocyte reactivity, antibody responses and neuroendocrine activation in rats

1988 • 99 citations

Vulnerability to Stress-Induced Tumor Growth Increases with Age in Rats: Role of Glucocorticoids*

1985 • 98 citations

The Developmental Biology Of T Lymphocytes

1988 • 98 citations

Early environmental programming hypothalamic-pituitary-adrenal responses to stress

1994 • 97 citations

Substance P: a late-acting B lymphocyte differentiation cofactor

1992 • 97 citations

Nuclear binding of glucocorticoid receptors: Relations between cytosol binding, activation and the biological response

1980 • 97 citations

Effect of Dexamethasone on Prostaglandin Synthesis and on Lipocortin Status in Human Endothelial Cells

1989 • 95 citations

Interleukin 1: a regulatory role in glucocorticoid-regulated hepatic metabolism.

1986 • 95 citations

Binding of [125I]corticotropin releasing factor to blood immunocytes and its reduction in Alzheimer's disease

1988 • 95 citations

Stress-induced modulation of the primary cellular immune response to herpes simplex virus infection is mediated by both adrenal-dependent and independent mechanisms

1993 • 95 citations

Neuroanatomy of lymphoid tissue: a review.

1985 • 95 citations

Stress and cancer: The state of the art

1981 • 94 citations

Effects of six different cytokines on lymphocyte adherence to microvascular endothelium and in vivo lymphocyte migration in the rat.

1990 • 94 citations

Primary Cortisol Resistance Accompanied by a Reduction in Glucocorticoid Receptors in Two Members of the Same Family*

1985 • 93 citations

Suppression of specific antibody production by inescapable shock: Stability under varying conditions

1988 • 93 citations

Biosynthesis and surface expression of T8 by peripheral blood T4+ cells in vitro.

1986 • 92 citations

Kinetics of glucocorticoid response to restraint stress and/or experimental influenza viral infection in two inbred strains of mice

1994 • 92 citations

Heat shock induces translocation to the nucleus of the unliganded glucocorticoid receptor.

1992 • 89 citations

Adrenal steroid receptor binding in spleen and thymus after stress or dexamethasone.

1990 • 89 citations

Shock-induced modulation of lymphocyte reactivity: Suppression, habituation, and recovery

1987 • 88 citations

EMOTIONS AND IMMUNITY

1969 • 88 citations

Immunomodulatory effects of corticosteroids on natural killer and antibody-dependent cellular cytotoxic activities of human lymphocytes.

1984 • 86 citations

Human immunodeficiency virus glycoprotein (gp120) infused into rat brain induces interleukin 1 to elevate pituitary-adrenal activity and decrease peripheral cellular immune responses.

1991 • 86 citations

Cytokine network and acute primary HIV-1 infection

1993 • 86 citations

The systemic influence of recombinant interleukin 2 on the manifestations of lepromatous leprosy.

1991 • 85 citations

Cholinergic receptors of lymphocytes

1989 • 84 citations

Stress-induced occupancy and translocation of hippocampal glucocorticoid receptors

1988 • 83 citations

Behavioral and neural influences on cellular immune responses: effects of stress and interleukin-1.

1989 • 83 citations

Thymus-derived lymphocytes and hydrocortisone: Identification of subsets of theta-bearing cells and redistribution to bone marrow

1972 • 82 citations

Inhibition of Macrophage Differentiation and Function by Cortisol

1990 • 82 citations

Interleukin 1 beta mediates stress-induced immunosuppression via corticotropin-releasing factor.

1992 • 81 citations

Stress-induced effects on cell-mediated innate and adaptive memory components of the murine immune response to herpes simplex virus infection

1991 • 81 citations

Consequences of restraint stress on natural killer cell activity, behavior, and hormone levels in rhesus macaques (Macaca mulatta)

1993 • 80 citations

A role for transforming growth factor-beta 1 in regulating natural killer cell and T lymphocyte proliferative responses during acute infection with lymphocytic choriomeningitis virus.

1991 • 80 citations

Endogenous blood levels of corticosterone control the immunologic cell mass and B cell activity in mice.

1984 • 79 citations

Effects of a low-fat diet on brain serotonergic responsivity in cynomolgus monkeys

1992 • 79 citations

Killing of immature CD4⁺CD8⁺ thymocytes in vivo by anti‐CD3 or 5′‐(N‐ethyl)‐carboxamido‐adenosine is blocked by glucocorticoid receptor antagonist RU‐486

1993 • 79 citations

Shock-induced modulation of lymphocyte responsiveness and natural killer activity: Differential mechanisms of induction

1988 • 77 citations

Modification of the murine immune system by glucocorticosteroids: Alterations of the tissue localization properties of circulating lymphocytes

1986 • 77 citations

The effects of ACTH, adrenalectomy and dexamethasone on the acquisition of an avoidance response in rats

1970 • 77 citations

Correlation between glucocorticoid receptor and cytolytic response of murine lymphoid cell lines.

1979 • 76 citations

Effects of Newcastle disease virus administration to mice on the metabolism of cerebral biogenic amines, plasma corticosterone, and lymphocyte proliferation

1987 • 75 citations

Disruption of hypothalamic-pituitary-adrenocortical system in transgenic mice expressing type II glucocorticoid receptor antisense ribonucleic acid permanently impairs T cell function: effects on T cell trafficking and T cell responsiveness during postnatal development.

1995 • 75 citations

Restraint stress differentially affects the pathogenesis of an experimental influenza viral infection in three inbred strains of mice

1993 • 74 citations

Prolonged increase of corticosterone secretion by chronic social stress does not necessarily impair immune funnctions

1992 • 73 citations

Early effects of corticosteroids on basophils, leukocyte histamine, and tissue histamine

1979 • 73 citations

Mechanism of glucocorticoid-induced increase in insulin receptors of cultured human lymphocytes.

1982 • 72 citations

Transforming growth factor-beta expression and natural killer cell responses during virus infection of normal, nude, and SCID mice.

1993 • 72 citations

Thymus-dependent and -independent regulation of Ia antigen expression in situ by cells in the synovium of rats with streptococcal cell wall-induced arthritis. Differences in site and intensity of expression in euthymic, athymic, and cyclosporin A-treated LEW and F344 rats.

1987 • 72 citations

Lymphocytic choriomeningitis virus: pathogenesis of acute central nervous system disease.

1971 • 72 citations

Cytokine cross‐talk between phagocytic cells and lymphocytes: Relevance for differentiation/activation of phagocytic cells and regulation of adaptive immunity

1993 • 72 citations

Delayed-type hypersensitivity to influenza virus. Induction of antigen-specific suppressor T cells for delayed-type hypersensitivity to hemagglutinin during influenza virus infection in mice.

1980 • 71 citations

Effect of Stress on Skin Transplantation Immunity in Mice

1960 • 71 citations

The role of natural killer cells and interferon in resistance to acute infection of mice with herpes simplex virus type 1.

1986 • 69 citations

Effect of interferon on thoracic duct lymphocyte output: induction with either poly I:poly C or vaccinia virus.

1983 • 68 citations

Decreased herpes simplex viral immunity and enhanced pathogenesis following stressor administration in mice

1992 • 68 citations

Changes in lymphocyte β-adrenergic receptor density and noradrenaline content of the spleen are early indicators of immune reactivity in acute experimental allergic encephalomyelitis in the Lewis rat

1989 • 68 citations

Modulation of the immune response by emotional stress

1987 • 67 citations

Inhibition of pituitary-adrenal activity as a consequence of consummatory behavior

1979 • 67 citations

Hormone specific regulation of natural killer cells by cortisol Direct inactivation of the cytotoxic function of cloned human NK cells without an effect on cellular proliferation

1991 • 67 citations

Stress and cancer: The state of the art Part 1

1980 • 67 citations

Physiologic and psychobehavioral research in oncology

1991 • 66 citations

Changes in β‐adrenergic receptor distribution on immunocytes during differentiation: An analysis of T cells and macrpphages

1991 • 66 citations

Localization and role of transcortin-like molecules in the anterior pituitary

1977 • 66 citations

The activation of IL-2 transcription in L3T4+ and Lyt-2+ lymphocytes during virus infection in vivo.

1989 • 66 citations

Relationship between antigen-induced immune stimulation and activation of the hypothalamic-pituitary-adrenal axis in the rat.

1993 • 65 citations

Phenotypic and functional analysis of the cellular response in regional lymphoid tissue during an acute virus infection.

1989 • 65 citations

The influence of cold or isolation stress on resistance of mice to West Nile virus encephalitis

1990 • 65 citations

Corticosteroid alteration of human monocyte to macrophage differentiation.

1982 • 64 citations

Stress and the Immune Response in Rats

1976 • 64 citations

The effect of restraint stress on the kinetics, magnitude, and isotype of the humoral immune response to influenza virus infection

1991 • 63 citations

Stressful experience, brain, and emotions: Developmental, genetic, and hormonal influences.

1995 • 63 citations

Stressor-induced alteration of lymphocyte proliferation in mice: Evidence for enhancement of mitogenic responsiveness

1990 • 63 citations

Repression of major histocompatibility complex IA expression by glucocorticoids: the glucocorticoid receptor inhibits the DNA binding of the X box DNA binding protein.

1993 • 62 citations

Stress Causes Reduced Natural Killer Activity in Mice

1983 • 62 citations

In vivo administration of IL-1 induces thymic hypoplasia and increased levels of serum corticosterone.

1988 • 62 citations

Pavlovian conditioning of shock-induced supression of lymphocyte reactivity: Acquisition, extinction, and preexposure effects

1988 • 62 citations

Inhibition of lymphocyte recirculation by stress and corticotropin

1972 • 62 citations

IFN induction and associated changes in splenic leukocyte distribution.

1993 • 62 citations

Factors modifying survival pathways of germinal center B cells. Glucocorticoids and transforming growth factor‐β, but not cyclosporin A or anti‐CD19, block surface immunoglobulin‐mediated rescue from apoptosis

1992 • 61 citations

The effects of stress on the development of immunological memory following low-dose antigen priming in mice

1990 • 61 citations

Suppression of experimental autoimmune encephalomyelitis by restraint stress: Sex differences

1993 • 61 citations

Immunosuppressive effects of low doses of glucocorticoids: effects on autologous and allogeneic mixed leukocyte reactions.

1980 • 61 citations

Expression of complement alternative pathway proteins by endothelial cells. Differential regulation by interleukin 1 and glucocorticoids

1990 • 60 citations

The genetics of alzheimer's disease: A review and a discussion of the implications

1986 • 60 citations

Diurnal differences in basal and acute stress levels of type I and type II adrenal steroid receptor activation in neural and immune tissues

1993 • 60 citations

The Influence of Avoidance-Learning Stress on Resistance to Coxsackie B Virus in Mice

1963 • 59 citations

Lipopolysaccharide increases glucocorticoid receptor expression in murine macrophages. A possible mechanism for glucocorticoid-mediated suppression of endotoxicity.

1992 • 59 citations

Human recombinant IL-1 alters glucocorticoid receptor function in Reuber hepatoma cells.

1988 • 58 citations

Establishment of Cell-to-Cell Contact by Adoptively Transferred Adherent Lymphokine-Activated Killer Cells With Metastatic Murine Melanoma Cells

1991 • 58 citations

Free Cortisol in Human Plasma

1980 • 58 citations

Long‐Term Selective Down‐Regulation of Brain Glucocorticoid Receptors after Neonatal Dexamethasone Treatment in Rats

1996 • 56 citations

Activated type II receptors in brain cannot rebind glucocorticoids: relationship to progesterone's antiglucocorticoid actions

1988 • 56 citations

IFN-gamma mediates increased glucocorticoid receptor expression in murine macrophages.

1992 • 56 citations

Hydrocortisone inhibition of human interleukin-4.

1992 • 56 citations

Specific changes in lymphocyte subpopulations: a potential mechanism for stress-induced immunomodulation

1992 • 54 citations

The Development of Rational Strategies for Selective Immunotherapy against Autoimmune Demyelinating Disease

1991 • 54 citations

Endogenous glucocorticoids restrain catecholamine synthesis and release at rest and during immobilization stress in rats

1993 • 54 citations

Physiology and pathology of an immunoendocrine feedback loop

1988 • 53 citations

Restraint stress-induced elevations in plasma corticosterone and β-endorphin are not accompanied by alterations in immune function

1990 • 53 citations

Cells Mediating Delayed‐Type Hypersensitivity in the Lungs of Mice Infected with an Influenza A Virus

1980 • 53 citations

Beta 2-adrenoceptor stimulation increases the number of antigen-specific precursor B lymphocytes that differentiate into IgM-secreting cells without affecting burst size.

1992 • 51 citations

Augmentation of glucocorticoid action on human monocytes by interleukin-4.

1990 • 51 citations

Enhancement of rat splenic lymphocyte mitogenesis after short term preexposure to corticosteroids in vitro.

1994 • 49 citations

Activated and non-activated glucocorticoid-receptor complexes in rat thymus cells: Kinetics of formation and relation to steroid structure

1980 • 48 citations

Effects of restraint stress on inoculated tumor growth and immune response in rats.

1985 • 48 citations

Parallel determination of mineralocorticoid and glucocorticoid receptors in T- and B-lymphocytes of human spleen

1988 • 47 citations

Eosinopenic Response to Cortisone and A.C.T.H. in Normal Subjects

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Modulation of Immune Function by Intestinal Neuropeptides

1991 • 47 citations

Nonspecific stress prevents relapses of experimental allergic encephalomyelitis in rats

1987 • 46 citations

AUTORADIOGRAPHIC STUDIES OF EOSINOPHIL KINETICS: EFFECTS OF CORTISOL*

1969 • 46 citations

Disruption of hypothalamic-pituitary-adrenocortical system in transgenic mice expressing type II glucocorticoid receptor antisense ribonucleic acid permanently impairs T cell function: effects on T cell trafficking and T cell responsiveness during postnatal development

1995 • 45 citations

The effects of the potent glucocorticoid budesonide on adhesion of eosinophils to human vascular endothelial cells and on endothelial expression of adhesion molecules.

1993 • 45 citations

Interleukin 1 beta mediates stress-induced immunosuppression via corticotropin-releasing factor

1992 • 45 citations

Interferon-alpha and dexamethasone inhibit adhesion of T cells to endothelial cells and synovial cells

1992 • 45 citations

Characterization of immune alterations induced by a conditioned aversive stimulus

1990 • 44 citations

Studies of psychosocial influences on coronary artery atherogenesis in cynomolgus monkeys.

1988 • 44 citations

Virus-induced alterations of lymphoid tissues

1970 • 44 citations

Down regulation of hepatic glucocorticoid receptors after endotoxin treatment

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Studies of psychosocial influences on coronary artery atherogenesis in cynomolgus monkeys.

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Enhancement of rat lymphocyte proliferation after prolonged exposure to stress☆

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Individual behavioral and neuroendocrine differences in responsiveness to audiogenic stress

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Influences of operative stress on cell‐mediated immunity and on tumor metastasis and their prevention by nonspecific immunotherapy: Experimental studies in rats

1982 • 38 citations

Effect of Physiological Stress on the Delayed Hypersensitivity Reaction

1965 • 38 citations

Influence of cytokines and cellular interactions on the glucocorticoid-induced Ig (E, G, A, M) synthesis of peripheral blood mononuclear cells.

1991 • 38 citations

Effects of selective type I and II adrenal steroid agonists on immune cell distribution

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Adrenal steroid receptor activation in vivo and immune function

1991 • 37 citations

Cyclosporin A inhibition of interleukin 2 gene expression, but not natural killer cell proliferation, after interferon induction in vivo.

1990 • 36 citations

Augmentation of the Resistance Against Listeria Monocytogenes by Oral Administration of A Hot Water Extt of Chlorella Vulgarism Mice

1994 • 36 citations

Adrenal Steroid Effects on the Brain: Versatile Hormones with Good and Bad Effects

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Cortisol at physiological concentrations and prostaglandin E2 are additive inhibitors of human natural killer cell activity

1986 • 35 citations

Relationship between antigen-induced immune stimulation and activation of the hypothalamic-pituitary-adrenal axis in the rat

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Effects of Cortisone and Antibiotics on Lethal Action of Endotoxins in Mice.

1954 • 35 citations

Selective suppressive effects of glucocorticoids on the early events in the human B cell activation process.

1984 • 34 citations

Differential expression of type I adrenal steroid receptors in immune tissues is associated with tissue-specific regulation of type II receptors by aldosterone.

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Electrical Stimulation of the Midbrain Mediates Metastatic Tumor Growth

1980 • 34 citations

Experimental allergic encephalomyelitis: Activation of myelin basic protein-sensitized spleen cells by specific antigen in culture

1981 • 33 citations

Differential Mineralocorticoid (Type 1) and Glucocorticoid (Type 2) Receptor Expression in Lewis and Fischer Rats

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Stress-Induced Immune Modulation in Animals: Opiates and Endogenous Opioid Peptides

1991 • 33 citations

The role of serum factors in the suppression of experimental allergic encephalomyelitis: evidence for immunoregulation by antibody to the encephalitogenic peptide.

1990 • 32 citations

Endocrine mediation of psychosocial stressor effects on mouse mammary tumor growth

1992 • 32 citations

Effects of cyclosporin A on IL-2 production and lymphocyte proliferation during infection of mice with lymphocytic choriomeningitis virus.

1990 • 32 citations

Glucocorticoids increase β-adrenoceptors on human intact lymphocytes

1984 • 31 citations

Glucocorticoid receptor conversion to high affinity nuclear binding and transcription enhancement activity in chinese hamster ovary cells subjected to heat and chemical stress

1993 • 31 citations

The effects of in vivo hydrocortisone on lymphocyte‐mediated cytotoxicity

1984 • 31 citations

Glucocorticoid hormones reduce the expression of major histocompatibility class I antigens on human epithelial cells

1990 • 31 citations

Susceptibility of natural killer cell activity of old rats to stress.

1987 • 30 citations

Antagonistic effects of gamma interferon and steroids on tissue antigenicity.

1986 • 30 citations

Activation of the glucocorticoid–receptor complex

1982 • 30 citations

Emotional stress and susceptibility to poliomyelitis virus infection in mice

1965 • 30 citations

The effects of corticosteroids on the antigen presenting properties of human monocytes and endothelial cells

1982 • 29 citations

Inhibition of anti-CD3 monoclonal antibody-induced T-cell proliferation by dexamethosone, isoproterenol, or prostaglandin E2 either alone or in combination

1992 • 29 citations

Glucocorticoid-mediated inhibition of interleukin-2 receptor α and -β subunit expression by human T cells

1994 • 29 citations

Synergistic regulation of pulmonary beta-adrenergic receptors by glucocorticoids and interleukin-1.

1988 • 29 citations

Suppression of the antigenic response of murine bone marrow B cells by physiological concentrations of glucocorticoids.

1991 • 27 citations

Stress and Immune Responses IV. Adrenal Involvement in the Alteration of Antibody Responses in Restraint-Stressed Mice

1986 • 27 citations

Opposing effects of dexamethasone on the clonal growth of granulocyte and macrophage progenitor cells and on the phagocytic capability of mononuclear phagocytes at different stages of differentiation

1985 • 26 citations

Psychosocial Influences on Herpesvirus Latency

1987 • 26 citations

Pertussis toxin inhibits activation-induced cell death of human thymocytes, pre-B leukemia cells and monocytes.

1994 • 25 citations

The timing of breast cancer surgery within the menstrual cycle

1994 • 24 citations

Central corticotropin releasing factor reduces natural cytotoxicity Time course of action

1989 • 24 citations

Regulation of Proenkephalin A Messenger Ribonucleic Acid Levels in Normal B Lymphocytes: Specific Inhibition by Glucocorticoid Hormones and Superinduction by Cycloheximide*

1991 • 24 citations

Enhancement by Restraint Stress of Natural Killer Cell Activity and Splenocyte Responsiveness to Concanavalin A in Fischer 344 Rats

1991 • 23 citations

Corticosteroids inhibit the generation of lymphokine-activated killer activity in vitro

1989 • 23 citations

[2] Standardization of assay of interferons

1981 • 23 citations

The effects of extended spaceflight on hematologic and immunologic systems.

1975 • 22 citations

IFN-gamma production in tissues of mice during acute infection with lymphocytic choriomeningitis virus.

1990 • 22 citations

The Effect of Epicutaneous Glucocorticostreroids on Human Monocyte and Neutrophil Migration in Vivo

1982 • 21 citations

Enhancement of rat splenic lymphocyte mitogenesis after short term preexposure to corticosteroids in vitro

1994 • 21 citations

In vitro corticosteroid modulation of lymphocyte migration

1980 • 21 citations

Depression of nonadaptive immunity after surgical stress: influence on metastatic spread.

1989 • 21 citations

Effect of Differential Housing in Mice on Natural Killer Cell Activity, Tumor Growth, and Plasma Corticosterone

1992 • 21 citations

Splenic noradrenergic and adrenocortical responses during the preclinical and clinical stages of adoptively transfered experimental autoimmune encephalomyelitis (EAE)

1990 • 20 citations

Asthma: Psychoneuroimmunologic Considerations

1991 • 20 citations

Glucocorticoid effect on arachidonic acid metabolism in vivo

1988 • 20 citations

Disrupted patterns of consummatory behavior in rats with fornix transections

1986 • 20 citations

In Vivo Antitumor Activity of Various Forms of Delayed-Type Hypersensitivity in Mice<xref ref-type="fn" rid="fn2">2</xref>

1979 • 20 citations

Protection from herpes simplex virus type 2 is associated with T cells involved in delayed type hypersensitivity that recognize glycosylation-related epitopes on glycoprotein D

1992 • 19 citations

Temporary Accumulation of Eosinophilic Leucocytes in Spleen of Mice Following Administration of Cortisone

1951 • 18 citations

Nongranular proteolytic enzymes of rat IL-2-activated natural killer cells. I. Subcellular localization and functional role.

1992 • 17 citations

Progress and challenges in psychosocial and behavioral research in cancer in the twentieth century

1991 • 17 citations

The Influence of Stress on Murine Leukemia Virus Infection

1968 • 17 citations

In Vivo Migration of Immune Cells

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PHYSIOLOGICAL RESPONSES TO HEAT STRESS AND ACTH OF NORMAL AND SCHIZOPHRENIC SUBJECTS

1951 • 16 citations

POTENTIATION OF KEYSTONE VIRUS INFECTION IN COTTON RATS BY GLUCOCORTICOID-INDUCED STRESS

1982 • 16 citations

The Effects of Cortisone on Acetylcholinesterase (AChE) in the Neonatal and Aged Thymusa

1988 • 15 citations

Differential expression of type I adrenal steroid receptors in immune tissues is associated with tissue-specific regulation of type II receptors by aldosterone

1993 • 15 citations

Therapeutic agents for treatment of established metastases and inhibitors of metastatic spread

1992 • 15 citations

Effect of adrenalectomy and steroid treatment on rat skin cytosol glucocorticoid receptor

1984 • 14 citations

Endocrine and Immunological Responses to Acute Stress

1986 • 14 citations

Natural killer cells and gene therapy: potential of gene transfection for optimizing effector cell functions and for targeting gene products into tumor metastases.

1994 • 14 citations

Effect of interleukin-6/interferon-β2 on glucocorticoid action in rat hepatoma cells

1989 • 12 citations

Effects of natural beta-interferon and recombinant alpha-2B-interferon on proliferation, glucocorticoid receptor content, and antigen expression in cultured HL-60 cells

1990 • 12 citations

Glucocorticoids upregulate the high affinity receptors for vasoactive intestinal peptide (VIP) on human mononuclear leucocytes in vitro

1991 • 12 citations

Isolation of a bovine serum albumin-specific T-suppressor cell clone and evaluation of its in vitro functions.

1987 • 11 citations

Nongranular proteolytic enzymes of rat IL‐2–activated natural killer cells. II. Purification and identification of rat A‐NKP 1 and A‐NKP 2 as constituents of the multicatalytic proteinase (proteasome) complex

1994 • 11 citations

Facilitation of Tumor Metastasis by Operative Stress and Participation of Cell-Mediated Immunity

1984 • 10 citations

Stress and the immune response

1986 • 10 citations

Psychoneuroimmunological Issues in Psycho-oncology

1993 • 10 citations

Overview of Current Understanding of Tumor Spread

1989 • 9 citations

Induction of CD8 antigen and suppressor activity by glucocorticoids in a CEM human leukemic cell clone

1993 • 8 citations

Metastasis and Neuroendocrine System in Stressed Micea

1992 • 8 citations

The effect of steroids on the circulating lymphocyte population. I. Changes in the thoracic duct lymphocyte population of the rat after neonatal thymectomy and prednisolone treatment.

1977 • 8 citations

Differentiation and Tolerance of CD4 ⁺ T Lymphocytes

2007 • 7 citations

Glucocorticoids modulate the induction of BLTE/granzyme A activity in the murine T cell hybridoma PC60

1992 • 7 citations

Suppressive and Permissive Actions of Glucocorticoids: A Way to Control Innate Immunity and to Facilitate Specificity of Adaptive Immunity?

1994 • 7 citations

Rotational Stress Reduces the Effectiveness of Antitumor Drugs in Micea

1994 • 7 citations

The effect of steroids on the circulating lymphocyte population. IV. The effect of stress on the thoracic duct lymphocyte population in normal and neonatally thymectomized rats.

1980 • 7 citations

Modification of the antitumor action of Corynebacterium parvum by stress

1986 • 6 citations

Long-term effects of ovariectomy on pituitary-adrenal axis and specific antibody response in rats

1991 • 5 citations

AUGMENTATION OF DELAYED-TYPE HYPERSENSITIVITY AND RESISTANCE AGAINST ALLOGENEIC OR SYNGENEIC METHYLCHOLANTHRENE-INDUCED TUMORS IN MICE PREIMMUNIZED WITH THE TUMOR EXTRACTS

1979 • 5 citations

Opposite effects of a glucocorticoid and an immunostimulating agent on prostaglandin production by two different cell types.

1985 • 4 citations

Murine suppressor T cell clones specific for minor histocompatibility antigens express CD4, CD8, and αβ T cell receptor molecules

1990 • 4 citations

Neuroendocrine modulation of tumor metastases. I. Effect of adrenalectomy on B16 melanoma metastases.

1994 • 3 citations

Natural Effector Cells in Influenza Virus Infection

1989 • 2 citations

The Source and Distribution of Autonomic Nervous System Nerves and Receptors within the Thymus Gland

1988 • 2 citations

Identification and Enrichment of Proteolytic Enzymes of IL-2 Activated Rat Natural Killer (A-NK) Cells: Potential Physiological Roles in NK Cell Function

2020 • 1 citations

Effects of Acute and Chronic Stress upon Lymphocyte Blastogenesis in Mice and Humans

2020 • 1 citations

Preface: Tumor invasion and brain cancer

1994 • 1 citations