The Stress Response and the Regulation of Inflammatory Disease

Characterization of a 41-Residue Ovine Hypothalamic Peptide that Stimulates Secretion of Corticotropin and β-Endorphin

1982 • 3,896 citations

Interleukin-1 Stimulates the Secretion of Hypothalamic Corticotropin-Releasing Factor

1987 • 1,512 citations

Corticotropin-Releasing Factor-Producing Neurons in the Rat Activated by Interleukin-1

1987 • 1,152 citations

Clinical and Biochemical Manifestations of Depression

1988 • 1,052 citations

Corticosteroid‐Mediated Immunoregulation in Man

1982 • 902 citations

Responses to Corticotropin-Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease

1986 • 773 citations

Interleukin-1 Immunoreactive Innervation of the Human Hypothalamus

1988 • 771 citations

Corticotropin releasing factor produces behavioural activation in rats

1982 • 752 citations

Evidence for Impaired Activation of the Hypothalamic-Pituitary-Adrenal Axis in Patients with Chronic Fatigue Syndrome

1991 • 736 citations

Inflammatory mediator-induced hypothalamic-pituitary-adrenal axis activation is defective in streptococcal cell wall arthritis-susceptible Lewis rats.

1989 • 723 citations

Release of Multiple Hormones by a Direct Action of Interleukin-1 on Pituitary Cells

1987 • 670 citations

Corticosteroids inhibit murine macrophage Ia expression and interleukin 1 production.

1982 • 665 citations

A central nervous system defect in biosynthesis of corticotropin-releasing hormone is associated with susceptibility to streptococcal cell wall-induced arthritis in Lewis rats.

1989 • 579 citations

Clinical and Biochemical Manifestations of Depression

1988 • 528 citations

Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA.

1988 • 510 citations

Corticotropin-Releasing Activity of Monokines

1985 • 500 citations

EFFECTS OF CORTISONE ACETATE AND PITUITARY ACTH ON RHEUMATOID ARTHRITIS, RHEUMATIC FEVER AND CERTAIN OTHER CONDITIONS

1950 • 491 citations

Autocrine or Paracrine Inflammatory Actions of Corticotropin-Releasing Hormone in Vivo

1991 • 485 citations

Human interleukin (IL) 1 alpha, murine IL-1 alpha and murine IL-1 beta are transported from blood to brain in the mouse by a shared saturable mechanism.

1991 • 449 citations

An Investigation of the Cause of the Eosinophilia–Myalgia Syndrome Associated with Tryptophan Use

1990 • 361 citations

Association of the Eosinophilia–Myalgia Syndrome with the Ingestion of Tryptophan

1990 • 361 citations

Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. Therapeutic implications.

1991 • 338 citations

Bidirectional transport of interleukin-1 alpha across the blood-brain barrier

1989 • 323 citations

Neuropeptides and Inflammation: The Role of Substance P

1989 • 285 citations

Synthesis of interleukin 1/endogenous pyrogen in the brain of endotoxin-treated mice: a step in fever induction?

1984 • 279 citations

Corticotropin releasing hormone related behavioral and neuroendocrine responses to stress in Lewis and Fischer rats

1992 • 265 citations

Scleroderma, Fasciitis, and Eosinophilia Associated with the Ingestion of Tryptophan

1990 • 248 citations

Adrenal secretion of cortisol in patients with rheumatoid arthritis.

1990 • 238 citations

Alpha melanocyte stimulating hormone inhibits immunostimulatory and inflammatory actions of interleukin 1.

1986 • 221 citations

The syndrome of hypopituitarism.

1949 • 217 citations

Antiinflammatory steroid action: Basic and clinical aspects

1990 • 202 citations

An assessment of the effects of glucocorticoids on degranulation, chemotaxis, binding to vascular endothelium and formation of leukotriene B4 by purified human neutrophils.

1989 • 202 citations

The role of the neuroendocrine system in determining genetic susceptibility to experimental allergic encephalomyelitis in the rat.

1990 • 201 citations

Effects of glucocorticosteroids on inflammatory cells relevant to their therapeutic applications in asthma.

1990 • 196 citations

Catecholamine effects upon rat hypothalamic corticotropin-releasing hormone secretion in vitro.

1988 • 190 citations

Lymphocyte structure and function

1978 • 184 citations

Characterization of "Peak E," a Novel Amino Acid Associated with Eosinophilia-Myalgia Syndrome

1990 • 182 citations

Restraint stress differentially affects anti-viral cellular and humoral immune responses in mice

1991 • 171 citations

The toxic and hematologic effects of interleukin-1 alpha administered in a phase I trial to patients with advanced malignancies.

1992 • 171 citations

Mechanisms of Serotonin Receptor Agonist-Induced Activation of the Hypothalamic-Pituitary-Adrenal Axis in the Rat

1990 • 167 citations

Distinct Subsets of Somatostatin Receptors on Cultured Human Lymphocytes

1989 • 166 citations

Brain IL-1-induced immunosuppression occurs through activation of both pituitary-adrenal axis and sympathetic nervous system by corticotropin- releasing factor

1990 • 157 citations

Cerebrospinal Fluid Immunoreactive Cortieotropin-Releasing Hormone and Adrenocorticotropin Secretion in Cushing's Disease and Major Depression: Potential Clinical Implications

1991 • 146 citations

Neuropeptide Innervation of Lymphoid Organsa

1990 • 143 citations

A phase I trial of recombinant human interleukin-1 beta alone and in combination with myelosuppressive doses of 5-fluorouracil in patients with gastrointestinal cancer

1991 • 141 citations

Virus infection as a stressor: Influenza virus elevates plasma concentrations of corticosterone, and brain concentrations of MHPG and tryptophan

1989 • 141 citations

Abnormal Pituitary-Adrenal Responses to Corticotropin-Releasing Hormone in Patients with Seasonal Affective Disorder: Clinical and Pathophysiological Implications

1991 • 135 citations

Eosinophilia-myalgia syndrome. Results of national surveillance

1990 • 133 citations

The pituitary gland is required for protection against lethal effects of Salmonella typhimurium.

1991 • 130 citations

In Vitroandin VivoEffects of the Triazolobenzodiazepine Alprazolam on Hypothalamic Pituitary-Adrenal Function: Pharmacological and Clinical Implications*

1990 • 114 citations

Intracerebroventricular administration of interleukin-1 to mice alters investigation of stimuli in a novel environment

1990 • 102 citations

L-tryptophan implicated in human eosinophilia-myalgia syndrome causes fasciitis and perimyositis in the Lewis rat.

1990 • 101 citations

Eosinophilia-Myalgia Syndrome

1990 • 98 citations

Action site of circulating interleukin-1 on the rabbit brain

1991 • 89 citations

Effects of Short and Long Duration Hypothyroidism and Hyperthyroidism on the Plasma Adrenocorticotropin and Corticosterone Responses to Ovine Corticotropin-Releasing Hormone in Rats*

1991 • 87 citations

Passage of immunomodulators across the blood-brain barrier.

1990 • 73 citations

Neurohormones regulate T cell function.

1990 • 64 citations

Autoantibodies to recombinant lipocortin-1 in rheumatoid arthritis and systemic lupus erythematosus.

1989 • 64 citations

Effect of glucocorticosteroids on microvascular permeability.

1990 • 61 citations

Alpha-MSH peptides inhibit acute inflammation and contact sensitivity

1990 • 59 citations

The multi-factorial pathogenesis of autoimmune disease

1987 • 54 citations

Interrelation of peptidergic innervation with mast cells and ED1-positive cells in rat thymus

1991 • 48 citations

1,1′-ethylidenebis(L-tryptophan), structure determination of contaminant “97” - implicated in the Eosinophilia-myalgia syndrome (EMS)

1991 • 45 citations

Corticosteroid Metabolism and Rheumatoid Arthritis

1957 • 44 citations

Dual-label retrograde transport: CNS innervation of the mouse thymus distinct from other mediastinum viscera

1990 • 42 citations

Production of neuropeptides by inflammatory cells within the granulomas of murine Schistosomiasis mansoni

1991 • 39 citations

Heart Rate Depression during Sleep Apnea Depends on Hypoxic Chemosensitivity: A Study at High Altitude

1990 • 37 citations

Neuroendocrine hormonal factors in rheumatoid arthritis and related conditions

1990 • 34 citations

Vasoactive Intestinal Peptide. Messenger in a Neuroimmune Axisa

1990 • 26 citations

Biological effects and possible clinical applications of interleukin 1.

1991 • 25 citations

Negative endocrine control system for inflammation in rats

1990 • 24 citations

High molecular weight peptide with corticotropin-releasing factor activity from porcine hypothalami.

1981 • 23 citations

Monokines, lymphokines, and the brain.

1989 • 23 citations

Cortisol catabolism by lymphocytes of patients with systemic lupus erythematosus and rheumatoid arthritis.

1990 • 19 citations

Stress Responses and the Pathogenesis of Arthritis

1991 • 13 citations

Voluntary consumption of cyclophosphamide by nondeprived Mrl-lpr/lpr and Mrl +/+ mice

1990 • 12 citations

Depression and rheumatoid arthritis.

1988 • 7 citations

Evidence for an Impairment of the Immune-Adrenal Circuit in Patients with Acquired Immunodeficiency Syndrome

1990 • 6 citations

Induction of feline immunodeficiency syndrome by feline leukemia virus

1990 • 6 citations

Dexamethasone modulated protein synthesis in polymorphonuclear leukocytes: response in rheumatoid arthritis.

1988 • 6 citations

Characteristics of Lymphocyte‐derived Proopiomelanocortin‐related mRNA

1990 • 2 citations