Structure of 85 kDa Subunit of Human Phosphatidylinositol 3‐Kinase Analyzed by Using Monoclonal Antibodies

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii

2007 • 11,720 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

Antibodies: A laboratory manual

1989 • 4,532 citations

SRα Promoter: an Efficient and Versatile Mammalian cDNA Expression System Composed of the Simian Virus 40 Early Promoter and the R-U5 Segment of Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

1988 • 1,351 citations

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

1988 • 1,027 citations

Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane Enzymes

1991 • 973 citations

A Retroviral Oncogene, akt , Encoding a Serine-Threonine Kinase Containing an SH2-Like Region

1991 • 900 citations

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

1985 • 813 citations

A novel viral oncogene with structural similarity to phospholipase C

1988 • 789 citations

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

1991 • 785 citations

Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

1987 • 670 citations

Cloning of bovine GAP and its interaction with oncogenic ras p21

1988 • 666 citations

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

1991 • 641 citations

SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat.

1988 • 638 citations

Binding of SH2 Domains of Phospholipase Cγ1, GAP, and Src to Activated Growth Factor Receptors

1990 • 608 citations

cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

1991 • 585 citations

Sequence similarity of phospholipase C with the non-catalytic region of src

1988 • 541 citations

Activation of phosphatidylinositol 3-kinase by insulin.

1990 • 531 citations

Role of Phosphatidylinositol Kinase in PDGF Receptor Signal Transduction

1989 • 516 citations

Src homology region 2 domains direct protein-protein interactions in signal transduction.

1990 • 498 citations

Molecular Cloning of Two Types of GAP Complementary DNA from Human Placenta

1988 • 492 citations

A Noncatalytic Domain Conserved among Cytoplasmic Protein-Tyrosine Kinases Modifies the Kinase Function and Transforming Activity of Fujinami Sarcoma Virus P130^gag-fps

1986 • 478 citations

Binding of Transforming Protein, P47 ^gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

1990 • 433 citations

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

1991 • 344 citations

The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase

1989 • 342 citations

A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps.

1986 • 317 citations

Phosphatidylinositol kinase or an associated protein is a substrate for the insulin receptor tyrosine kinase.

1990 • 266 citations

The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase.

1991 • 259 citations

Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase.

1990 • 244 citations

Association of cdk2 Kinase with the Transcription Factor E2F During S Phase

1992 • 239 citations

Inositol phospholipid-specific phospholipase C: complete cDNA and protein sequences and sequence homology to tyrosine kinase-related oncogene products.

1988 • 223 citations

Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B-cell antigen receptor-mediated signaling.

1992 • 212 citations

Phosphatidylinositol kinase activity associates with viral p60src protein.

1989 • 194 citations

SH2 Domains of the p85α Subunit of Phosphatidylinositol 3-Kinase Regulate Binding to Growth Factor Receptors

1992 • 186 citations

Activated type I phosphatidylinositol kinase is associated with the epidermal growth factor (EGF) receptor following EGF stimulation.

1990 • 185 citations

Selective binding of activated pp60c-src by an immobilized synthetic phosphopeptide modeled on the carboxyl terminus of pp60c-src.

1991 • 175 citations

A guanine nucleotide-dependent phosphatidylinositol 4,5-diphosphate phospholipase C in cells transformed by the v-fms and v-fes oncogenes.

1986 • 168 citations

Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor.

1990 • 167 citations

Interleukin-2 receptor regulates activation of phosphatidylinositol 3-kinase

1991 • 166 citations

A Second Type of Rat Phosphoinositide-specific Phospholipase C Containing a src-related Sequence Not Essential for Phosphoinositide-hydrolyzing Activity

1989 • 160 citations

Two types of phosphatidylinositol 3-kinase from bovine thymus. Monomer and heterodimer form

1991 • 151 citations

Structural features of the colony-stimulating factor 1 receptor that affect its association with phosphatidylinositol 3-kinase.

1990 • 146 citations

The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of phosphatidylinositol 3-kinase to phosphorylated platelet-derived growth factor beta receptor.

1992 • 143 citations

Phosphatidylinositol 3-Phosphate Is Present in Normal and Transformed Fibroblasts and Is Resistant to Hydrolysis by Bovine Brain Phospholipase C II

1989 • 137 citations

STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases.

1991 • 128 citations

Membrane Ig cross-linking regulates phosphatidylinositol 3-kinase in B lymphocytes.

1992 • 128 citations

Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins.

1991 • 127 citations

IL-2 binding activates a tyrosine-phosphorylated phosphatidylinositol-3-kinase.

1991 • 126 citations

Thrombin-dependent association of phosphatidylinositol-3 kinase with p60c-src and p59fyn in human platelets.

1990 • 126 citations

Phosphatidylinositol 3-Kinase and Its Novel Product, Phosphatidylinositol 3-phosphate, Are Present in Saccharomyces cerevisiae

1989 • 118 citations

The CD19 complex of B lymphocytes. Activation of phospholipase C by a protein tyrosine kinase-dependent pathway that can be enhanced by the membrane IgM complex.

1991 • 116 citations

Interleukin 2- and Polyomavirus Middle T Antigen-Induced Modification of Phosphatidylinositol 3-Kinase Activity in Activated T Lymphocytes

1991 • 98 citations

Phosphatidylinositol kinase type I activity associates with various oncogene products.

1989 • 98 citations

Mutations of the Platelet-Derived Growth Factor Receptor That Cause a Loss of Ligand-Induced Conformational Change, Subtle Changes in Kinase Activity, and Impaired Ability To Stimulate DNA Synthesis

1989 • 89 citations

SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors.

1992 • 74 citations

Phosphatidylinositol turnover and transformation of cells by Abelson murine leukaemia virus.

1985 • 61 citations

Phosphatidylinositol-3 kinase is activated in v-src, v-yes, and v-fps transformed chicken embryo fibroblasts.

1991 • 60 citations

Interleukin 2- and polyomavirus middle T antigen-induced modification of phosphatidylinositol 3-kinase activity in activated T lymphocytes.

1991 • 58 citations

Mutations of the platelet-derived growth factor receptor that cause a loss of ligand-induced conformational change, subtle changes in kinase activity, and impaired ability to stimulate DNA synthesis.

1989 • 54 citations

Phosphatidylinositol Kinase Activity Associates with Viral p60^src Protein

1989 • 46 citations

Baculovirus expression of functional P210 BCR-ABL oncogene product.

1989 • 39 citations

Interactions of Phosphatidylinositol Kinase, GTPase-Activating Protein (GAP), and GAP-Associated Proteins with the Colony-Stimulating Factor 1 Receptor

1990 • 38 citations

STY, a Tyrosine-Phosphorylating Enzyme with Sequence Homology to Serine/Threonine Kinases

1991 • 35 citations

Biological and biochemical activity of v-Crk chimeras containing the SH2/SH3 regions of phosphatidylinositol-specific phospholipase C-gamma and Src

1992 • 33 citations

Identification of Domains of the v-crk Oncogene Product Sufficient for Association with Phosphotyrosine-Containing Proteins

1991 • 30 citations

Preferential Generation of Monoclonal IgG-Producing Hybridomas by Use of Vesicular Stomatitis Virus-Mediated Cell Fusion

1991 • 26 citations

Thrombin-Dependent Association of Phosphatidylinositol-3 Kinase with p60^c-src and p59^fyn in Human Platelets

1990 • 20 citations

Cited By (0)

No citing papers found in database