Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins.

Vectors for selective expression of cloned DNAs by T7 RNA polymerase

1987 • 1,449 citations

A novel viral oncogene with structural similarity to phospholipase C

1988 • 789 citations

Cloning of bovine GAP and its interaction with oncogenic ras p21

1988 • 666 citations

Binding of SH2 Domains of Phospholipase Cγ1, GAP, and Src to Activated Growth Factor Receptors

1990 • 608 citations

Sequence similarity of phospholipase C with the non-catalytic region of src

1988 • 541 citations

Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses

1983 • 518 citations

Src homology region 2 domains direct protein-protein interactions in signal transduction.

1990 • 498 citations

Polyoma virus transforming protein associates with the product of the c-src cellular gene

1983 • 497 citations

Molecular Cloning of Two Types of GAP Complementary DNA from Human Placenta

1988 • 492 citations

A Noncatalytic Domain Conserved among Cytoplasmic Protein-Tyrosine Kinases Modifies the Kinase Function and Transforming Activity of Fujinami Sarcoma Virus P130^gag-fps

1986 • 478 citations

Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation.

1985 • 439 citations

Two genes required for cell fusion during yeast conjugation: evidence for a pheromone-induced surface protein.

1987 • 439 citations

Binding of Transforming Protein, P47 ^gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

1990 • 433 citations

Cloning of a 67-kD Neutrophil Oxidase Factor with Similarity to a Noncatalytic Region of p60 ^c-src

1990 • 393 citations

Recombinant 47-Kilodalton Cytosol Factor Restores NADPH Oxidase in Chronic Granulomatous Disease

1989 • 341 citations

Rat cell line 3y1 and its virogenic polyoma‐ and SV40‐transformed derivatives

1975 • 340 citations

A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps.

1986 • 317 citations

Homology of a yeast actin-binding protein to signal transduction proteins and myosin-I

1990 • 315 citations

Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase.

1989 • 310 citations

N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl.

1989 • 288 citations

Non-catalytic domains of cytoplasmic protein-tyrosine kinases: regulatory elements in signal transduction.

1988 • 250 citations

Rous sarcoma virus variants that carry the cellular src gene instead of the viral src gene cannot transform chicken embryo fibroblasts.

1984 • 239 citations

Inositol phospholipid-specific phospholipase C: complete cDNA and protein sequences and sequence homology to tyrosine kinase-related oncogene products.

1988 • 223 citations

Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3

1990 • 209 citations

Deletion of an N-terminal regulatory domain of the c-abl tyrosine kinase activates its oncogenic potential.

1989 • 207 citations

Two Genes Required for Cell Fusion During Yeast Conjugation: Evidence for a Pheromone-Induced Surface Protein

1987 • 205 citations

RAPID TRANSFORMATION OF CELLS BY ROUS SARCOMA VIRUS

1969 • 203 citations

Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity.

1990 • 191 citations

Local mutagenesis of Rous sarcoma virus: The major sites of tyrosine and serine phosphorylation of p60src are dispensable for transformation

1983 • 189 citations

Association of the polyomavirus middle-T antigen with c-yes protein

1987 • 172 citations

Amino acid substitutions sufficient to convert the nontransforming p60c-src protein to a transforming protein.

1986 • 171 citations

Stable Association of Activated pp60^src with Two Tyrosine-Phosphorylated Cellular Proteins

1989 • 168 citations

Primary structure of the brain alpha-spectrin [published erratum appears in J Cell Biol 1989 Mar;108(3):following 1175]

1989 • 164 citations

A C-terminal domain of GAP is sufficient to stimulate ras p21 GTPase activity.

1989 • 161 citations

A Second Type of Rat Phosphoinositide-specific Phospholipase C Containing a src-related Sequence Not Essential for Phosphoinositide-hydrolyzing Activity

1989 • 160 citations

Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src.

1990 • 151 citations

Mutagenic analysis of the v-crk oncogene: requirement for SH2 and SH3 domains and correlation between increased cellular phosphotyrosine and transformation

1990 • 128 citations

Phosphorylation of cellular proteins in Rous sarcoma virus-infected cells: analysis by use of anti-phosphotyrosine antibodies.

1988 • 121 citations

Linker insertion-deletion mutagenesis of the v-src gene: isolation of host- and temperature-dependent mutants

1989 • 107 citations

Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteins.

1989 • 100 citations

A conserved domain regulates interactions of the v-fps protein-tyrosine kinase with the host cell.

1987 • 89 citations

N-terminal deletions in Rous sarcoma virus p60src: effects on tyrosine kinase and biological activities and on recombination in tissue culture with the cellular src gene.

1985 • 88 citations

Activation of the proto-oncogene p60c-src by point mutations in the SH2 domain.

1990 • 85 citations

Activation of pp60c-src transforming potential by mutations altering the structure of an amino terminal domain containing residues 90-95.

1988 • 85 citations

Site-directed mutagenesis of the src gene of Rous sarcoma virus: construction and characterization of a deletion mutant temperature sensitive for transformation

1982 • 83 citations

Analysis of the catalytic domain of phosphotransferase activity of two avian sarcoma virus-transforming proteins.

1984 • 81 citations

Epitope Mapping of Monoclonal Antibodies to gag Protein p19 of Avian Sarcoma and Leukaemia Viruses

1987 • 78 citations

Deletions and insertions within an amino-terminal domain of pp60v-src inactivate transformation and modulate membrane stability

1989 • 75 citations

Biological properties of "partial" transformation mutants of Rous sarcoma virus and characterization of their pp60src kinase

1981 • 62 citations

Characterization of p47gag-crk, a Novel Oncogene Product with Sequence Similarity to a Putative Modulatory Domain of Protein-Tyrosine Kinases and Phospholipase C

1988 • 58 citations

Phosphorylation of Cellular Proteins in Rous Sarcoma Virus-Infected Cells: Analysis by Use of Anti-Phosphotyrosine Antibodies

1988 • 54 citations

Transformation of rat cells by fusion-infection with Rous sarcoma virus

1980 • 52 citations

Small deletion in src of Rous sarcoma virus modifying transformation phenotypes: identification of 207-nucleotide deletion and its smaller product with protein kinase activity

1983 • 52 citations

Molecular cloning and characterization of avian sarcoma virus UR2 and comparison of its transforming sequence with those of other avian sarcoma viruses

1984 • 50 citations

Identification of an amino terminal domain required for the transforming activity of the Rous sarcoma virus src protein

1987 • 41 citations

Catalytic and non-catalytic domains of the Fujinami sarcoma virus P130gag-fps protein-tyrosine kinase distinguished by the expression of v-fps polypeptides in Escherichia coli.

1987 • 30 citations

Phosphotyrosine-containing 120,000-dalton protein coimmunoprecipitated with pp60v-src from rous sarcoma virus-transformed mammalian cells

1986 • 27 citations

Src homology 2 domain deletion mutants of p60v-src do not phosphorylate cellular proteins of 120-150 kDa.

1989 • 20 citations

Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase

1989 • 19 citations

Morphf mutants of Rous sarcoma virus: nucleotide sequencing analysis suggests that a class of morphf mutants was generated through splicing of a cryptic intron

1987 • 15 citations

The amino-terminal region of pp60c-src has a modulatory role and contains multiple sites of tyrosine phosphorylation.

1990 • 15 citations

Purification and characterization of P47gag-crk expressed in insect cells.

1990 • 11 citations

Evidence that a phosphotyrosine-containing 120,000 Da protein from Rous sarcoma virus-infected cells is phosphorylated by pp60v-src.

1989 • 8 citations

Local Similarity in the Amino Acid Sequence between the Non-Catalytic Region of Rous Sarcoma Virus Oncogene Product p60v-src and Intermediate Filament Proteins1

1988 • 7 citations