Activated type I phosphatidylinositol kinase is associated with the epidermal growth factor (EGF) receptor following EGF stimulation.

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate

1983 • 2,596 citations

Induction of c-fos gene and protein by growth factors precedes activation of c-myc

1984 • 1,463 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.

1976 • 1,293 citations

RECEPTORS FOR EPIDERMAL GROWTH FACTOR AND OTHER POLYPEPTIDE MITOGENS

1987 • 1,274 citations

Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.

1980 • 1,184 citations

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

1988 • 1,027 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

1989 • 933 citations

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

1985 • 813 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

Autophosphorylation sites on the epidermal growth factor receptor

1984 • 730 citations

Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system

1979 • 727 citations

Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts

1983 • 721 citations

Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

1987 • 670 citations

Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells

1981 • 669 citations

Direct visualization of the binding and internalization of a ferritin conjugate of epidermal growth factor in human carcinoma cells A-431.

1979 • 528 citations

Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins

1989 • 524 citations

Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses

1983 • 518 citations

Role of Phosphatidylinositol Kinase in PDGF Receptor Signal Transduction

1989 • 516 citations

Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol.

1984 • 476 citations

Epidermal-Growth-Factor-Dependent Transformation by a Human EGF Receptor Proto-Oncogene

1987 • 448 citations

Enhancement of calcium uptake and phosphatidylinositol turnover by epidermal growth factor in A-431 cells

1981 • 426 citations

High-efficiency gene transfer into mammalian cells: generation of helper-free recombinant retrovirus with broad mammalian host range.

1984 • 407 citations

Pituitary Extracts and Steroid Hormones in the Control of 3T3 Cell Growth

1973 • 387 citations

Identification of multiple novel polypeptide substrates of the v-src, v-yes, v-fps, v-ros, and v-erb-B oncogenic tyrosine protein kinases utilizing antisera against phosphotyrosine.

1988 • 351 citations

An 81 kd protein complexed with middle T antigen and pp60c-src: A possible phosphatidylinositol kinase

1987 • 346 citations

The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase

1989 • 342 citations

Epidermal Growth Factor: Receptors in Human Fibroblasts and Modulation of Action by Cholera Toxin

1973 • 328 citations

Antiphosphotyrosine Recovery of Phospholipase C Activity After EGF Treatment of A-431 Cells

1988 • 324 citations

Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation

1987 • 307 citations

Polyphosphoinositides Produced by Phosphatidylinositol 3-Kinase Are Poor Substrates for Phospholipases C from Rat Liver and Bovine Brain

1989 • 238 citations

Phosphorylation of middle T by pp60c-src: A switch for binding of phosphatidylinositol 3-kinase and optimal tumorigenesis

1989 • 178 citations

Epidermal growth factor and angiotensin II stimulate formation of inositol 1,4,5- and inositol 1,3,4-trisphosphate in hepatocytes. Differential inhibition by pertussis toxin and phorbol 12-myristate 13-acetate.

1987 • 168 citations

Tyrosine Phosphorylation of Phospholipase C-II in Vitro by the Epidermal Growth Factor Receptor

1989 • 145 citations

Phosphatidylinositol 3-Phosphate Is Present in Normal and Transformed Fibroblasts and Is Resistant to Hydrolysis by Bovine Brain Phospholipase C II

1989 • 137 citations

Epidermal growth factor (EGF) stimulates inositol trisphosphate formation in cells which overexpress the EGF receptor

1987 • 99 citations

Phosphatidylinositol kinase type I activity associates with various oncogene products.

1989 • 98 citations

Epidermal growth factor receptor synthesis is stimulated by phorbol ester and epidermal growth factor. Evidence for a common mechanism.

1987 • 76 citations

Separation and characterization of a phosphatidylinositol kinase activity that co-purifies with the epidermal growth factor receptor.

1985 • 61 citations

Phosphatidylinositol kinase is activated in membranes derived from cells treated with epidermal growth factor.

1987 • 53 citations

Inability of anti-epidermal growth factor receptor monoclonal antibody to block “autocrine” growth stimulation in transforming growth factor-secreting melanoma cells.

1984 • 44 citations

Epidermal growth factor stimulates formation of inositol phosphates in BALB/c/3T3 cells pretreated with cholera toxin and isobutylmethylxanthine.

1988 • 43 citations

Epidermal growth factor-induced truncation of the epidermal growth factor receptor

1989 • 32 citations

Epidermal growth factor-nonresponsive 3T3 variants do not contain epidermal growth factor receptor-related antigens or mRNA.

1986 • 32 citations

Expression of a molecularly cloned human c-src oncogene by using a replication-competent retroviral vector.

1986 • 24 citations

Epidermal growth factor‐induced increases in inositol trisphosphates, inositol tetrakisphosphates, and cytosolic Ca²⁺ in a human hepatocellular carcinoma‐derived cell line

1988 • 23 citations

Expression of a Molecularly Cloned Human c-src Oncogene by Using a Replication-Competent Retroviral Vector

1986 • 4 citations