Ex vivo analysis of tumor antigen specific CD8+ T cell responses using MHC/peptide tetramers in cancer patients

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C

1998 • 2,114 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.

1991 • 1,946 citations

Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma

1998 • 1,826 citations

Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs.

1968 • 1,363 citations

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

1996 • 1,281 citations

Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.

1981 • 1,281 citations

Vaccination with Mage-3a1 Peptide–Pulsed Mature, Monocyte-Derived Dendritic Cells Expands Specific Cytotoxic T Cells and Induces Regression of Some Metastases in Advanced Stage IV Melanoma

1999 • 1,260 citations

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

1999 • 1,131 citations

Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor.

1994 • 1,108 citations

TELOMERE LENGTH REGULATION

1996 • 1,010 citations

A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.

1994 • 934 citations

Direct Visualization of Antigen-specific CD8+T Cells during the Primary Immune Response to Epstein-Barr Virus In Vivo

1998 • 902 citations

Tracking the Response of Natural Killer T Cells to a Glycolipid Antigen Using Cd1d Tetramers

2000 • 891 citations

HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function

2000 • 879 citations

T CELL MEMORY

1998 • 863 citations

Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes.

1994 • 850 citations

Tumor regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by geneMAGE-3 and presented by HLA-A1

1999 • 803 citations

Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia

2000 • 679 citations

Alterations in Signal Transduction Molecules in T Lymphocytes from Tumor-Bearing Mice

1992 • 650 citations

Structure, chromosomal localization, and expression of 12 genes of the MAGE family

1994 • 595 citations

The Telomerase Catalytic Subunit Is a Widely Expressed Tumor-Associated Antigen Recognized by Cytotoxic T Lymphocytes

1999 • 574 citations

Determination of antigen-specific memory/effector CD4+ T cell frequencies by flow cytometry: evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency.

1997 • 560 citations

Ex Vivo Staining of Metastatic Lymph Nodes by Class I Major Histocompatibility Complex Tetramers Reveals High Numbers of Antigen-experienced Tumor-specific Cytolytic T Lymphocytes

1998 • 534 citations

A Re-Evaluation of the Frequency of CD8+ T Cells Specific for EBV in Healthy Virus Carriers

1999 • 520 citations

A Kinetic Basis For T Cell Receptor Repertoire Selection during an Immune Response

1999 • 515 citations

High Frequencies of Naive Melan-a/Mart-1–Specific Cd8+ T Cells in a Large Proportion of Human Histocompatibility Leukocyte Antigen (Hla)-A2 Individuals

1999 • 497 citations

Reverse ELISPOT assay for clonal analysis of cytokine production I. Enumeration of gamma-interferon-secreting cells

1988 • 496 citations

Enhanced Generation of Specific Tumor-Reactive CTL In Vitro by Selected Melan-A/MART-1 Immunodominant Peptide Analogues

1998 • 487 citations

Loss of HLA class I antigens by melanoma cells: molecular mechanisms, functional significance and clinial relevance

1995 • 478 citations

Detection of Antigen-Specific T Cells with Multivalent Soluble Class II MHC Covalent Peptide Complexes

1998 • 465 citations

Isolation of High Avidity Melanoma-Reactive CTL from Heterogeneous Populations Using Peptide-MHC Tetramers

1999 • 423 citations

Melanocyte Destruction after Antigen-Specific Immunotherapy of Melanoma

2000 • 423 citations

Monitoring CD8 T cell responses to NY-ESO-1: Correlation of humoral and cellular immune responses

2000 • 407 citations

CD28- T lymphocytes. Antigenic and functional properties.

1993 • 403 citations

MHC class II tetramers identify peptide-specific human CD4+ T cells proliferating in response to influenza A antigen

1999 • 379 citations

Self Antigens Expressed by Solid Tumors Do Not Efficiently Stimulate Naive or Activated T Cells: Implications for Immunotherapy

1997 • 316 citations

Is cancer dangerous to the immune system?

1996 • 296 citations

Increased Vaccine-Specific T Cell Frequency After Peptide-Based Vaccination Correlates with Increased Susceptibility to In Vitro Stimulation But Does Not Lead to Tumor Regression

1999 • 290 citations

Enhancement of cellular immunity in melanoma patients immunized with a peptide from MART-1/Melan A.

1997 • 286 citations

Inverse relationship of melanocyte differentiation antigen expression in melanoma tissues and CD8+ cytotoxic-T-cell responses: Evidence for immunoselection of antigen-loss variantsin vivo

1996 • 274 citations

A New Look at T Cells

1998 • 269 citations

Cutting Edge: Cytolytic Effector Function in Human Circulating CD8+ T Cells Closely Correlates with CD56 Surface Expression

2000 • 263 citations

An inverse relationship between T cell receptor affinity and antigen dose during CD4⁺T cell responsesin vivoandin vitro

1999 • 259 citations

Cytotoxic T cell immunity against telomerase reverse transcriptase in humans

2000 • 259 citations

The Relationship of MHC-Peptide Binding and T Cell Activation Probed Using Chemically Defined MHC Class II Oligomers

2000 • 254 citations

Activation-induced apoptosis in lymphocytes

1994 • 238 citations

Identification of functional subsets by flow cytometry: Intracellular detection of cytokine expression

1998 • 219 citations

Induction of Rapid T Cell Activation and Tolerance by Systemic Presentation of an Orally Administered Antigen

1998 • 219 citations

Human tumor antigens recognized by T cells

1996 • 217 citations

Immunization against epitopes in the human melanoma antigen gp100 following patient immunization with synthetic peptides.

1996 • 215 citations

Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors

2000 • 205 citations

In Vivo Expression of Natural Killer Cell Inhibitory Receptors by Human Melanoma–Specific Cytolytic T Lymphocytes

1999 • 202 citations

Enrichment and detection of live antigen-specific CD4+ and CD8+ T cells based on cytokine secretion

1999 • 199 citations

An Expanded Peripheral T Cell Population to a Cytotoxic T Lymphocyte (Ctl)-Defined, Melanocyte-Specific Antigen in Metastatic Melanoma Patients Impacts on Generation of Peptide-Specific Ctls but Does Not Overcome Tumor Escape from Immune Surveillance in Metastatic Lesions

1999 • 197 citations

Naturally occurring human lymphocyte antigen-A2 restricted CD8+ T-cell response to the cancer testis antigen NY-ESO-1 in melanoma patients.

2000 • 192 citations

Faces and phases of human CD8+ T-cell development

1999 • 187 citations

Heterogeneous expression of immunotherapy candidate proteins gp100, MART-1, and tyrosinase in human melanoma cell lines and in human melanocytic lesions.

1997 • 187 citations

A PR1-human leukocyte antigen-A2 tetramer can be used to isolate low-frequency cytotoxic T lymphocytes from healthy donors that selectively lyse chronic myelogenous leukemia.

1999 • 177 citations

Cytolytic T lymphocyte recognition of the immunodominant HLA-A*0201-restricted Melan-A/MART-1 antigenic peptide in melanoma.

1997 • 176 citations

Identification of NY-ESO-1 Peptide Analogues Capable of Improved Stimulation of Tumor-Reactive CTL

2000 • 172 citations

Heterogeneous expression of melanoma-associated antigens and HLA-A2 in metastatic melanoma in vivo

1998 • 166 citations

Efficient detection and immunomagnetic sorting of specific T cells using multimers of MHC class I and peptide with reduced CD8 binding

2000 • 155 citations

Cutting Edge: In Situ Tetramer Staining of Antigen-Specific T Cells in Tissues

2000 • 143 citations

Use of soluble peptide–DR4 tetramers to detect synovial T cells specific for cartilage antigens in patients with rheumatoid arthritis

2000 • 138 citations

A Shift in the Phenotype of Melan-A-Specific CTL Identifies Melanoma Patients with an Active Tumor-Specific Immune Response

2000 • 138 citations

Quantitation of antigen-reactive T cells in peripheral blood by IFNγ-ELISPOT assay and chromium-release assay: a four-centre comparative trial

2000 • 135 citations

Quantitative assessment of the pool size and subset distribution of cytolytic T lymphocytes within human resting or alloactivated peripheral blood T cell populations.

1983 • 134 citations

HLA-DQ Tetramers Identify Epitope-Specific T Cells in Peripheral Blood of Herpes Simplex Virus Type 2-Infected Individuals: Direct Detection of Immunodominant Antigen-Responsive Cells

2000 • 126 citations

Status of Activation of Circulating Vaccine-Elicited CD8+ T Cells

2000 • 118 citations

Quantification of antigen‐reactive cells among human T lymphocytes

1978 • 106 citations

Use of fluorogenic histocompatibility leukocyte antigen-A*0201/HPV 16 E7 peptide complexes to isolate rare human cytotoxic T-lymphocyte-recognizing endogenous human papillomavirus antigens.

2000 • 104 citations

Interleukin-2-induced, melanoma-specific T cells recognize camel, an unexpected translation product ofLAGE-1

1999 • 103 citations

Rapid Determination of Epstein-Barr Virus–Specific CD8+T-Cell Frequencies by Flow Cytometry

1999 • 100 citations

High Frequency of Autologous Anti-Melanoma CTL Directed Against an Antigen Generated by a Point Mutation in a New Helicase Gene

2000 • 97 citations

Tetramer-Guided Analysis of TCR β-Chain Usage Reveals a Large Repertoire of Melan-A-Specific CD8+ T Cells in Melanoma Patients

2000 • 91 citations

Efficient Simultaneous Presentation of NY-ESO-1/LAGE-1 Primary and Nonprimary Open Reading Frame-Derived CTL Epitopes in Melanoma

2000 • 86 citations

Generation and purification of CD8+ melan-A-specific cytotoxic T lymphocytes for adoptive transfer in tumor immunotherapy.

2000 • 85 citations

In situ detection of virus- and tumor-specific T-cell immunity

2000 • 79 citations

Expansion of Tumor-T Cell Pairs from Fine Needle Aspirates of Melanoma Metastases

2000 • 76 citations

Cytolytic T Lymphocytes Recognize an Antigen Encoded by MAGE-A10 on a Human Melanoma

1999 • 76 citations

Analysis of the cytolytic T lymphocyte response of melanoma patients to the naturally HLA-A*0201-associated tyrosinase peptide 368-376.

1999 • 71 citations

Killer inhibitory receptor (CD158b) modulates the lytic activity of tumor-specific T lymphocytes infiltrating renal cell carcinomas

2000 • 70 citations

Frequent cytolytic T-cell responses to peptide MAGE-A10(254-262) in melanoma.

2001 • 70 citations

Antiviral immunity

1997 • 69 citations

An antigen-targeted approach to adoptive transfer therapy of cancer.

1999 • 64 citations

Human CD8+ T cells expressing HLA-DR and CD28 show telomerase activity and are distinct from cytolytic effector T cells

2001 • 52 citations

Cd8^high+ (CD57+) T cells in patients with rheumatoid arthritis

1997 • 47 citations

CD8+ T-cell response to NY-ESO-1: relative antigenicity and in vitro immunogenicity of natural and analogue sequences.

2001 • 45 citations

High avidity melanoma-reactive cytotoxic T lymphocytes are efficiently induced from peripheral blood lymphocytes on stimulation by peptide-pulsed melanoma cells.

2000 • 43 citations

Human Immunodeficiency Virus Type 1 Envelope Epitope-Specific CD4⁺T Lymphocytes in Simian/Human Immunodeficiency Virus-Infected and Vaccinated Rhesus Monkeys Detected Using a Peptide-Major Histocompatibility Complex Class II Tetramer

2000 • 31 citations

Differential expression of CD28 and CD94 / NKG2 on T cells with identical TCR beta variable regions in primary melanoma and sentinel lymph node

2000 • 26 citations

Cytolytic T lymphocyte responses of cancer patients to tumor-associated antigens

1996 • 16 citations