A study of complexes of class II invariant chain peptide: Major histocompatibility complex class II molecules using a new complex‐specific monoclonal antibody

Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: Evidence for membrane cycling from Golgi to ER

1989 • 1,685 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.

1993 • 900 citations

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

1992 • 763 citations

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

1991 • 663 citations

Peptides Presented to the Immune System by the Murine Class II Major Histocompatibility Complex Molecule I-A _d

1992 • 654 citations

Brefeldin A redistributes resident and itinerant Golgi proteins to the endoplasmic reticulum.

1989 • 581 citations

MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

1990 • 565 citations

Intracellular transport of class II MHC molecules directed by invariant chain

1990 • 548 citations

Degradation from the endoplasmic reticulum: Disposing of newly synthesized proteins

1988 • 488 citations

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

1990 • 486 citations

Dissection of the Golgi complex. I. Monensin inhibits the transport of viral membrane proteins from medial to trans Golgi cisternae in baby hamster kidney cells infected with Semliki Forest virus.

1983 • 430 citations

Isolation and characterization of the intracellular MHC class II compartment

1994 • 426 citations

MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding

1991 • 394 citations

HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides

1992 • 380 citations

An essential role for HLA–DM in antigen presentation by class II major histocompatibility molecules

1994 • 378 citations

Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cells

1994 • 349 citations

Role for intracellular proteases in the processing and transport of class II HLA antigens.

1988 • 336 citations

Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain

1991 • 326 citations

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.

1993 • 326 citations

Membrane insertion and oligomeric assembly of HLA-DR histocompatibility antigens

1982 • 308 citations

Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways

1990 • 303 citations

On the complexity of self

1991 • 261 citations

HLA-DMA and DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells

1994 • 247 citations

Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells

1994 • 247 citations

Developmental regulation of IgM secretion: The role of the carboxy-terminal cysteine

1990 • 245 citations

Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs

1992 • 234 citations

Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes.

1992 • 219 citations

Invariant Chain Peptides in Most HLA-DR Molecules of an Antigen-Processing Mutant

1992 • 218 citations

The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules.

1994 • 196 citations

Assembly and transport properties of invariant chain trimers and HLA-DR-invariant chain complexes.

1992 • 189 citations

Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II.

1995 • 186 citations

The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancy.

1994 • 184 citations

Degradation of newly synthesized apolipoprotein B-100 in a pre-Golgi compartment.

1990 • 182 citations

Endosomal aspartic proteinases are required for invariant-chain processing.

1994 • 182 citations

A novel MHC class II epitope expressed in thymic medulla but not cortex

1989 • 175 citations

Dissection of the Golgi complex. II. Density separation of specific Golgi functions in virally infected cells treated with monensin.

1983 • 144 citations

The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation.

1992 • 125 citations

The segment of invariant chain that is critical for association with major histocompatibility complex class II molecules contains the sequence of a peptide eluted from class II polypeptides.

1993 • 123 citations

Mapping functional regions in the lumenal domain of the class II-associated invariant chain.

1994 • 122 citations

Intracellular assembly and transport of endogenous peptide-MHC class II complexes

1994 • 111 citations

The invariant chain of murine ia antigens: Its glycosylation, abundance and subcellular localization

1981 • 108 citations

A mutant human histocompatibility leukocyte antigen DR molecule associated with invariant chain peptides.

1994 • 91 citations

Antigen presentation and assembly by mouse I-Ak class II molecules in human APC containing deleted or mutated HLA DM genes.

1994 • 78 citations

Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell lines.

1994 • 77 citations

MHC class II deletion mutant expresses normal levels of transgene encoded class II molecules that have abnormal conformation and impaired antigen presentation ability.

1992 • 72 citations

Structurally interdependent and independent regions of allelic polymorphism in class II MHC molecules. Implications for Ia function and evolution.

1990 • 67 citations

T cell recognition of major histocompatibility complex class II complexes with invariant chain processing intermediates.

1995 • 58 citations

Degradation of T-cell receptor chains in the endoplasmic reticulum is inhibited by inhibitors of cysteine proteases.

1991 • 37 citations