Altered Beta-adrenergic Receptor Gene Regulation and Signaling in Chronic Heart Failure

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1986 • 1,297 citations

Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A

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β-Adrenergic Receptor Blockade in Chronic Heart Failure

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1994 • 745 citations

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1995 • 714 citations

Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors

1992 • 703 citations

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1994 • 696 citations

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1985 • 692 citations

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1998 • 690 citations

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1987 • 577 citations

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1986 • 564 citations

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1999 • 557 citations

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1991 • 555 citations

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1988 • 545 citations

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1995 • 544 citations

HuR Regulates p21 mRNA Stabilization by UV Light

2000 • 534 citations

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2000 • 514 citations

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1997 • 511 citations

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1997 • 493 citations

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1998 • 482 citations

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1993 • 470 citations

Medical Therapy Can Improve the Biological Properties of the Chronically Failing Heart

1996 • 468 citations

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2001 • 452 citations

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1996 • 451 citations

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1990 • 449 citations

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1999 • 449 citations

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2000 • 415 citations

Gene expression informatics —it's all in your mine

1999 • 406 citations

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2000 • 396 citations

Early and Delayed Consequences of β ₂ -Adrenergic Receptor Overexpression in Mouse Hearts

2000 • 395 citations

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1999 • 379 citations

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1998 • 378 citations

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2000 • 374 citations

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1989 • 370 citations

Pleckstrin Homology Domain-mediated Membrane Association and Activation of the β-Adrenergic Receptor Kinase Requires Coordinate Interaction with Gβγ Subunits and Lipid

1995 • 360 citations

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1998 • 353 citations

Functional coupling of the beta 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes.

1995 • 350 citations

The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure.

1998 • 350 citations

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1999 • 325 citations

Increase of Gi alpha in human hearts with dilated but not ischemic cardiomyopathy.

1990 • 324 citations

Beta-adrenergic pathways in nonfailing and failing human ventricular myocardium.

1990 • 319 citations

Phosphorylation and Desensitization of the Human β1-Adrenergic Receptor

1995 • 317 citations

Effects of carvedilol on left ventricular mass, chamber geometry, and mitral regurgitation in chronic heart failure

1999 • 314 citations

Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein.

1985 • 312 citations

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1989 • 308 citations

Rapid β-Adrenergic Modulation of Cardiac Calcium Channel Currents by a Fast G Protein Pathway

1989 • 307 citations

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1996 • 302 citations

Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart.

1994 • 300 citations

Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy

2000 • 298 citations

Reduced Ca2+-Sensitivity of SERCA 2a in Failing Human Myocardium due to Reduced Serin-16 Phospholamban Phoshorylation

1999 • 282 citations

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1999 • 279 citations

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1998 • 278 citations

Down-regulation of beta-adrenergic receptors: agonist-induced reduction in receptor mRNA levels.

1988 • 268 citations

Agonist-induced Destabilization of β-Adrenergic Receptor mRNA

1989 • 267 citations

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1996 • 266 citations

Myocardial-Directed Overexpression of the Human β1-Adrenergic Receptor in Transgenic Mice

2000 • 264 citations

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2000 • 263 citations

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1991 • 254 citations

Beta 1-adrenoceptor stimulation and beta 2-adrenoceptor stimulation differ in their effects on contraction, cytosolic Ca2+, and Ca2+ current in single rat ventricular cells.

1993 • 241 citations

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1999 • 240 citations

Reduced beta 1 receptor messenger RNA abundance in the failing human heart.

1993 • 237 citations

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1997 • 232 citations

Calcineurin Promotes Protein Kinase C and c-Jun NH2-terminal Kinase Activation in the Heart

2000 • 232 citations

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1999 • 229 citations

Calcineurin-Mediated Hypertrophy Protects Cardiomyocytes From Apoptosis In Vitro and In Vivo

2000 • 228 citations

Calcineurin and Beyond

2000 • 227 citations

Low- and high-level transgenic expression of β ₂ -adrenergic receptors differentially affect cardiac hypertrophy and function in Gαq-overexpressing mice

1999 • 227 citations

Assembly of an A kinase-anchoring protein–β 2 -adrenergic receptor complex facilitates receptor phosphorylation and signaling

2000 • 219 citations

The peptide product of a 5' leader cistron in the beta 2 adrenergic receptor mRNA inhibits receptor synthesis.

1994 • 210 citations

β-Adrenergic Receptor Subtypes Differentially Affect Apoptosis in Adult Rat Ventricular Myocytes

2000 • 209 citations

Dynamic Complexes of β2-Adrenergic Receptors with Protein Kinases and Phosphatases and the Role of Gravin

1999 • 208 citations

Changes in myocardial and vascular receptors in heart failure

1993 • 199 citations

Beta 2-adrenergic receptor-stimulated increase in cAMP in rat heart cells is not coupled to changes in Ca2+ dynamics, contractility, or phospholamban phosphorylation.

1994 • 199 citations

Mechanisms of β-Adrenergic Receptor Desensitization and Resensitization

1997 • 193 citations

Desensitization of the isolated .beta.2-adrenergic receptor by .beta.-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms

1992 • 187 citations

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1975 • 185 citations

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2000 • 179 citations

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1996 • 177 citations

Cardiac-Directed Adenylyl Cyclase Expression Improves Heart Function in Murine Cardiomyopathy

1999 • 175 citations

Phospholamban and Cardiac Contractile Function

2000 • 171 citations

Apoptosis of Cardiac Myocytes in Gsα Transgenic Mice

1999 • 168 citations

Conditional expression of a G _i -coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy

2000 • 166 citations

β1-Adrenergic Receptor Association with PSD-95

2000 • 166 citations

β-Adrenergic Pathway Induces Apoptosis through Calcineurin Activation in Cardiac Myocytes

2000 • 164 citations

Cardiomyopathy induced by cardiac Gs alpha overexpression

1997 • 163 citations

p38 Mitogen-activated Protein Kinase Pathway Protects Adult Rat Ventricular Myocytes against β-Adrenergic Receptor-stimulated Apoptosis

2000 • 161 citations

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2000 • 160 citations

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1992 • 156 citations

A Single Site (Ser16) Phosphorylation in Phospholamban Is Sufficient in Mediating Its Maximal Cardiac Responses to β-Agonists

2000 • 153 citations

Both Gs and Gi Proteins Are Critically Involved in Isoproterenol-induced Cardiomyocyte Hypertrophy

1999 • 153 citations

Depressed Heart Rate Variability and Arterial Baroreflex in Conscious Transgenic Mice With Overexpression of Cardiac G _sα

1998 • 150 citations

DESENSITIZATION OF G-PROTEIN–COUPLED RECEPTORS IN THE CARDIOVASCULAR SYSTEM

1999 • 150 citations

Regulation of the mRNA-binding Protein AUF1 by Activation of the β -Adrenergic Receptor Signal Transduction Pathway

1996 • 149 citations

β ₂ -Adrenergic and Several Other G Protein–Coupled Receptors in Human Atrial Membranes Activate Both G _s and G _i

2000 • 147 citations

Adhesion-Dependent Regulation of an A+U-Rich Element-Binding Activity Associated with AUF1

1997 • 146 citations

Protein kinase C isoform diversity in the heart

1995 • 146 citations

Molecular Analysis of β₂-Adrenoceptor Coupling to G_s-, G_i-, and G_q-Proteins

2000 • 146 citations

Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the β1-adrenergic receptor

1999 • 145 citations

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2001 • 143 citations

Overexpression of Gs alpha protein in the hearts of transgenic mice.

1995 • 140 citations

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2000 • 140 citations

cAMP concentrations, cAMP dependent protein kinase activity, and phospholamban in non-failing and failing myocardium

1994 • 134 citations

A cAMP response element in the beta 2-adrenergic receptor gene confers transcriptional autoregulation by cAMP.

1990 • 132 citations

β2-Adrenergic Receptor-induced p38 MAPK Activation Is Mediated by Protein Kinase A Rather than by Gi or Gβγ in Adult Mouse Cardiomyocytes

2000 • 126 citations

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1999 • 124 citations

Adrenergic hormones and control of cardiac myocyte growth

1991 • 122 citations

β-Adrenergic receptor blockade arrests myocyte damage and preserves cardiac function in the transgenic Gsα mouse

1999 • 120 citations

Acute Effects of β ₁ -Selective and Nonselective β-Adrenergic Receptor Blockade on Cardiac Sympathetic Activity in Congestive Heart Failure

1996 • 117 citations

Thyroid hormones transcriptionally regulate the beta 1-adrenergic receptor gene in cultured ventricular myocytes

1991 • 111 citations

Characterization of a Unique Genetic Variant in the β1-adrenoceptor Gene and Evaluation of its Role in Idiopathic Dilated Cardiomyopathy

1999 • 109 citations

Interactions Between Phospholamban and β-Adrenergic Drive May Lead to Cardiomyopathy and Early Mortality

2001 • 107 citations

Racial differences in the frequencies of cardiac ?1-adrenergic receptor polymorphisms: Analysis of c145A>G and c1165G>C

1999 • 106 citations

Distinct regulation of beta 1- and beta 2-adrenergic receptors in Chinese hamster fibroblasts.

1992 • 106 citations

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1995 • 105 citations

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2000 • 105 citations

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1997 • 103 citations

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1989 • 99 citations

Differential Activation of p38 Mitogen-activated Protein Kinase Isoforms Depending on Signal Strength

2000 • 98 citations

A proline-rich region of the third intracellular loop imparts phenotypic beta 1-versus beta 2-adrenergic receptor coupling and sequestration

1994 • 98 citations

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1984 • 90 citations

Maximal Inhibition of SERCA2 Ca2+ Affinity by Phospholamban in Transgenic Hearts Overexpressing a Non-phosphorylatable Form of Phospholamban

2000 • 89 citations

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1993 • 85 citations

Down-regulation of β-adrenergic receptor : agonist-induced reduction in mRNA levels

1988 • 82 citations

The functional importance of beta1 and beta2 adrenoceptors in the human heart

1988 • 76 citations

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1998 • 67 citations

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1967 • 63 citations

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2000 • 63 citations

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1985 • 60 citations

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1998 • 60 citations

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2000 • 58 citations

G proteins and cardiovascular disease.

1988 • 57 citations

Spontaneous Activation of β₂- but Not β₁-Adrenoceptors Expressed in Cardiac Myocytes from β₁β₂Double Knockout Mice

2000 • 57 citations

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1997 • 54 citations

Evidence for norepinephrine cardiotoxicity mediated by superoxide anion radicals in isolated rabbit hearts

1994 • 53 citations

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2000 • 50 citations

Cloning and sequence analysis of the human β1-adrenergic receptor 5′-flanking promoter region

1993 • 49 citations

Glucocorticoids down-regulate β1-adrenergic-receptor expression by suppressing transcription of the receptor gene

1994 • 47 citations

Identification of a Glucocorticoid Response Element in the Rat β₂-Adrenergic Receptor Gene

1998 • 46 citations

Overexpression of myocardial Gsalpha prevents full expression of catecholamine desensitization despite increased beta-adrenergic receptor kinase.

1998 • 45 citations

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1991 • 43 citations

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2000 • 38 citations

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1995 • 36 citations

Regulation of Mitogen-Activated Protein Kinase Signaling Networks by G Protein-Coupled Receptors

2000 • 35 citations

α_2c‐Adrenoceptor‐modulated release of noradrenaline in human right atrium

1995 • 34 citations

The effects of chronic, sustained-release moxonidine therapy on clinical and neurohumoral status in patients with heart failure

2000 • 34 citations

Distinct receptor domains determine subtype-specific coupling and desensitization phenotypes for human beta1- and beta2-adrenergic receptors.

1996 • 31 citations

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2000 • 30 citations

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1986 • 29 citations

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1998 • 27 citations

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1996 • 27 citations

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1996 • 25 citations

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1970 • 25 citations

β₂-Adrenergic receptor-selective agonist clenbuterol prevents Fas-induced liver apoptosis and death in mice

1999 • 24 citations

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1998 • 23 citations

Glucocorticoid induction of ?-adrenergic receptors in the DDT1 MF-2 smooth muscle cell line involves synthesis of new receptor

1987 • 23 citations

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1999 • 18 citations

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1989 • 17 citations

Beta 2-adrenergic receptors enhance contractility by stimulating HCO3(-)-dependent intracellular alkalinization

1997 • 17 citations

Identification of a glucocorticoid repressor domain in the rat beta 1-adrenergic receptor gene.

1996 • 15 citations

Identification of a Retinoic Acid Response Domain Involved in the Activation of the β1-Adrenergic Receptor Gene by Retinoic Acid in F9 Teratocarcinoma Cells

1998 • 8 citations

Localisation of Cardiac GSαin Transgenic Mice Overexpressing GSα

1997 • 6 citations

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1991 • 3 citations