A Gain-of-function Polymorphism in a G-protein Coupling Domain of the Human β1-Adrenergic Receptor

Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure.

1986 • 1,297 citations

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

1993 • 1,213 citations

STRUCTURE AND FUNCTION OF G PROTEIN-COUPLED RECEPTORS

1994 • 1,070 citations

[71] Use of eukaryotic expression technology in the functional analysis of cloned genes

1987 • 834 citations

Epidemiology of heart failure

1991 • 822 citations

Amino-Terminal Polymorphisms of the Human .beta.2-Adrenergic Receptor Impart Distinct Agonist-Promoted Regulatory Properties

1994 • 780 citations

Palmitoylation of the human β2-adrenergic receptor

1989 • 599 citations

Cloning of the cDNA for the human beta 1-adrenergic receptor.

1987 • 577 citations

A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor.

1993 • 470 citations

Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells.

1995 • 443 citations

Site-directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling.

1988 • 400 citations

Beta 1- and beta 2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium.

1989 • 370 citations

Rapid β-Adrenergic Modulation of Cardiac Calcium Channel Currents by a Fast G Protein Pathway

1989 • 307 citations

Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: thermodynamic interpretation of negative antagonism and of receptor activity in the absence of ligand.

1992 • 232 citations

Adrenergic Receptors — Evolving Concepts and Clinical Implications

1996 • 201 citations

Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors.

1988 • 160 citations

Intermittent, ambulatory dobutamine infusions in patients with severe congestive heart failure

1986 • 155 citations

Sustained Activation of a G Protein-coupled Receptor via “Anchored” Agonist Binding

1996 • 155 citations

Beta 1- and beta 2-adrenergic receptors display subtype-selective coupling to Gs.

1992 • 117 citations

A proline-rich region of the third intracellular loop imparts phenotypic beta 1-versus beta 2-adrenergic receptor coupling and sequestration

1994 • 98 citations

Chimeric Mutagenesis of Putative G-protein Coupling Domains of the α2A-Adrenergic Receptor

1996 • 86 citations

Use of Alkyltrimethylammonium Bromides for the Isolation of Ribo- and Deoxribo-nucleic Acids

1963 • 62 citations

[35S]GTPγS binding: A tool to evaluate functional activity of a cloned opioid receptor transiently expressed in COS cells

1996 • 42 citations

Distinct receptor domains determine subtype-specific coupling and desensitization phenotypes for human beta1- and beta2-adrenergic receptors.

1996 • 31 citations

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