A Single Site (Ser16) Phosphorylation in Phospholamban Is Sufficient in Mediating Its Maximal Cardiac Responses to β-Agonists

Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation.

1994 • 696 citations

Phospholamban: Protein Structure, Mechanism of Action, and Role in Cardiac Function

1998 • 566 citations

Fractional SR Ca release is regulated by trigger Ca and SR Ca content in cardiac myocytes

1995 • 545 citations

Concerted regulation of cardiac sarcoplasmic reticulum calcium transport by cyclic adenosine monophosphate dependent and calcium-calmodulin-dependent phosphorylations

1979 • 454 citations

Sequence analysis of phospholamban. Identification of phosphorylation sites and two major structural domains.

1986 • 435 citations

Phospholamban: A Prominent Regulator of Myocardial Contractility

1996 • 346 citations

Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice.

1996 • 319 citations

Phospholamban Phosphorylation in Intact Ventricles

1989 • 289 citations

Characterization of a transient outward K⁺ current with inward rectification in canine ventricular myocytes

1998 • 256 citations

Phosphorylation of phospholamban by calcium-activated, phospholipid-dependent protein kinase. Stimulation of cardiac sarcoplasmic reticulum calcium uptake.

1984 • 255 citations

In Vivo Echocardiographic Detection of Enhanced Left Ventricular Function in Gene-Targeted Mice With Phospholamban Deficiency

1995 • 241 citations

Cyclic GMP-dependent protein kinase phosphorylates phospholamban in isolated sarcoplasmic reticulum from cardiac and smooth muscle

1988 • 223 citations

Effect of ablation of phospholamban on dynamics of cardiac myocyte contraction and intracellular Ca2+

1996 • 161 citations

Calcium Sparks and Excitation–Contraction Coupling in Phospholamban‐Deficient Mouse Ventricular Myocytes

1997 • 142 citations

Frequency-encoding Thr17 Phospholamban Phosphorylation Is Independent of Ser16 Phosphorylation in Cardiac Myocytes

2000 • 140 citations

Phospholamban Regulates the Ca2+-ATPase through Intramembrane Interactions

1996 • 139 citations

Effects of phospholamban phosphorylation catalyzed by adenosine 3′:5′-monophosphate- and calmodulin-dependent protein kinases on calcium transport ATPase of cardiac sarcoplasmic reticulum

1983 • 136 citations

Regulation of Ca2+ transport by cyclic 3′,5′-AMP-dependent and calcium-calmodulin-dependent phosphorylation of cardiac sarcoplasmic reticulum

1985 • 123 citations

Phosphorylation of phospholamban in intact myocardium. Role of Ca2+-calmodulin-dependent mechanisms.

1985 • 120 citations

Phospholamban Gene Dosage Effects in the Mammalian Heart

1996 • 118 citations

Transgenic Approaches to Define the Functional Role of Dual Site Phospholamban Phosphorylation

1998 • 112 citations

Immunodetection of Phosphorylation Sites Gives New Insights into the Mechanisms Underlying Phospholamban Phosphorylation in the Intact Heart

1996 • 112 citations

Regulation of cardiac sarcoplasmic reticulum calcium transport by calcium-calmodulin-dependent phosphorylation.

1983 • 104 citations

Dependence of cardiac sarcoplasmic reticulum calcium pump activity on the phosphorylation status of phospholamban.

1991 • 90 citations

Phosphorylation States of Phospholamban^a

1998 • 86 citations

Sites of Regulatory Interaction between Calcium ATPases and Phospholamban^a

1998 • 61 citations

Mechanisms Involved in the Acidosis Enhancement of the Isoproterenol-induced Phosphorylation of Phospholamban in the Intact Heart

1998 • 50 citations

Monomeric Phospholamban Overexpression in Transgenic Mouse Hearts

1997 • 50 citations

Pentameric Assembly of Phospholamban Facilitates Inhibition of Cardiac Function in Vivo

1998 • 49 citations

Translation of Ser16 and Thr17 phosphorylation of phospholamban into Ca2+-pump stimulation

1996 • 47 citations

Co-ordinated changes in cAMP, phosphorylated phospholamban, Ca 2+ and contraction following β-adrenergic stimulation of rat heart

1998 • 44 citations

A basolateral CHIP28/MIP26-related protein (BLIP) in kidney principal cells and gastric parietal cells

1994 • 34 citations

Acidosis alters the phosphorylation of Ser 16 and Thr 17 of phospholamban in rat cardiac muscle

1997 • 33 citations

Phosphorylation of phospholamban in the intact heart. A study on the physiological role of the Ca2+-calmodulin-dependent protein kinase system

1992 • 30 citations