Pharmacogenetics of Beta-1- and Beta-2-Adrenergic Receptors

Complex promoter and coding region β ₂ -adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness

2000 • 971 citations

Amino-Terminal Polymorphisms of the Human .beta.2-Adrenergic Receptor Impart Distinct Agonist-Promoted Regulatory Properties

1994 • 780 citations

Mutations in the Gene Encoding for the β₂-adrenergic Receptor in Normal and Asthmatic Subjects

1993 • 633 citations

Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing.

1997 • 624 citations

A Gain-of-function Polymorphism in a G-protein Coupling Domain of the Human β1-Adrenergic Receptor

1999 • 588 citations

The Effect of Polymorphisms of the β₂-Adrenergic Receptor on the Response to Regular Use of Albuterol in Asthma

2000 • 560 citations

A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor.

1993 • 470 citations

Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells.

1995 • 443 citations

Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function.

1997 • 418 citations

Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype.

1995 • 407 citations

Comparison of Regularly Scheduled with As-Needed Use of Albuterol in Mild Asthma

1996 • 353 citations

The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure.

1998 • 350 citations

Association between β2-adrenoceptor polymorphism and susceptibility to bronchodilator desensitisation in moderately severe stable asthmatics

1997 • 342 citations

Association of Glu 27 β2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects

1995 • 298 citations

Polymorphisms of the 5' leader cistron of the human beta2-adrenergic receptor regulate receptor expression.

1998 • 278 citations

Impact of genetic polymorphisms of the β -adrenergic receptor on albuterol bronchodilator pharmacodynamics

1999 • 256 citations

β₂-Adrenergic Receptor Haplotypes in Mild, Moderate and Fatal/Near Fatal Asthma

1998 • 201 citations

Myocardial signaling defects and impaired cardiac function of a human beta 2-adrenergic receptor polymorphism expressed in transgenic mice.

1996 • 177 citations

β-2 Adrenoceptor genetic variation is associated with genetic predisposition to essential hypertension: The Bergen Blood Pressure Study

1998 • 144 citations

Polymorphism of the beta2-adrenoceptor and the response to long-term beta2-agonist therapy in asthma

1998 • 132 citations

β2-Adrenergic receptor polymorphisms at amino acid 16 differentially influence agonist-stimulated blood pressure and peripheral blood flow in normal individuals

2000 • 117 citations

Identification of novel polymorphisms within the promoter region of the human β₂ adrenergic receptor gene

1999 • 111 citations

Racial differences in the frequencies of cardiac ?1-adrenergic receptor polymorphisms: Analysis of c145A>G and c1165G>C

1999 • 106 citations

Effects of Genetic Polymorphism on Ex Vivo and In Vivo Function of β2-Adrenoceptors in Asthmatic Patients

1999 • 78 citations

Polymorphism in the 5′-Leader Cistron of theβ 2-Adrenergic Receptor Gene Associated with Obesity and Type 2 Diabetes

1999 • 74 citations

β 2-Adrenoceptor polymorphism and bronchoprotective sensitivity with regular short- and long-acting β2-agonist therapy

1999 • 64 citations

Beta 2 adrenergic receptor gene restriction fragment length polymorphism and bronchial asthma.

1995 • 63 citations

[beta ]-Adrenergic receptor polymorphisms at amino acid 16 differentially influence agonist-stimulated blood pressure and peripheral blood flow in normal individuals

2000 • 38 citations