A cAMP response element in the beta 2-adrenergic receptor gene confers transcriptional autoregulation by cAMP.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.

1986 • 1,424 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

Cyclic AMP and the induction of eukaryotic gene transcription.

1988 • 1,041 citations

A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence

1989 • 914 citations

A cyclic AMP- and phorbol ester-inducible DNA element

1986 • 780 citations

Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA

1988 • 772 citations

Cell-Specific Expression of the Rat Insulin Gene: Evidence for Role of Two Distinct 5′ Flanking Elements

1985 • 698 citations

Identification of DNA sequences required for transcription of the human α1-globin gene in a new SV40 host-vector system

1981 • 624 citations

Adrenergic receptors. Models for the study of receptors coupled to guanine nucleotide regulatory proteins.

1988 • 455 citations

Tissue-specific enhancer of the human glycoprotein hormone alpha-subunit gene: dependence on cyclic AMP-inducible elements.

1987 • 409 citations

Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription.

1988 • 342 citations

Structure of mouse metallothionein-I gene and its mRNA

1981 • 301 citations

Cyclic AMP regulation of the human glycoprotein hormone alpha-subunit gene is mediated by an 18-base-pair element.

1987 • 293 citations

Two distinct pathways for cAMP-mediated down-regulation of the β2-adrenergic receptor

1989 • 271 citations

A family of immunologically related transcription factors that includes multiple forms of ATF and AP-1.

1988 • 259 citations

Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions.

1987 • 248 citations

Regulation of transcription by cyclic AMP-dependent protein kinase.

1989 • 247 citations

Cyclic AMP responsiveness of human gonadotropin-alpha gene transcription is directed by a repeated 18-base pair enhancer. Alpha-promoter receptivity to the enhancer confers cell-preferential expression.

1987 • 216 citations

cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure.

1989 • 200 citations

Expression of cDNAs for two isoforms of the catalytic subunit of cAMP-dependent protein kinase.

1987 • 194 citations

The regulated expression of β-globin genes introduced into mouse erythroleukemia cells

1983 • 186 citations

The catalytic subunit of cAMP-dependent protein kinase induces expression of genes containing cAMP-responsive enhancer elements

1988 • 186 citations

The CGTCA sequence motif is essential for biological activity of the vasoactive intestinal peptide gene cAMP-regulated enhancer.

1988 • 181 citations

Cyclic AMP stabilizes the mRNA for phosphoenolpyruvate carboxykinase (GTP) against degradation.

1988 • 165 citations

Identification of multiple protein binding domains in the promoter-regulatory region of the phosphoenolpyruvate carboxykinase (GTP) gene

1989 • 152 citations

Cyclic AMP regulation of lactate dehydrogenase. Isoproterenol and N6,O2-dibutyryl cyclic amp increase the rate of transcription and change the stability of lactate dehydrogenase a subunit messenger RNA in rat C6 glioma cells.

1983 • 146 citations

Activation of cAMP-dependent protein kinase is required for heterologous desensitization of adenylyl cyclase in S49 wild-type lymphoma cells.

1988 • 144 citations

Functional characterization of a cAMP-responsive element of the rat insulin I gene.

1990 • 107 citations

Genetic regulation of β2-adrenergic receptors in 3T3-L1 fibroblasts

1989 • 55 citations

Cyclic AMP and phorbol esters interact synergistically to regulate expression of the chorionic gonadotropin genes.

1988 • 52 citations

Direct evidence that the protein kinase catalytic subunit mediates the effects of cAMP on tyrosine aminotransferase synthesis.

1983 • 49 citations

Isoproterenol response following transfection of the mouse beta 2-adrenergic receptor gene into Y1 cells.

1988 • 48 citations

Presence of both beta1- and beta2-adrenergic receptors in a single cell type.

1981 • 48 citations

Increased turnover of the messenger RNA encoding tyrosine aminotransferase can account for the desensitization and de-induction of tyrosine aminotransferase by 8-bromo-cyclic AMP treatment and removal.

1988 • 18 citations

A rapid affinity method for isolation and characterization of sequence specific DNA binding factor

1987 • 11 citations

Further characterization of leukotriene d 4 ltd 4 receptors in the guinea pig left atria gpla

1990 • 2 citations