Design of the Beta-Blocker Evaluation Survival Trial (BEST)

Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure.

1986 • 1,297 citations

Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy

1993 • 1,218 citations

Effect of chronic beta-adrenergic receptor blockade in congestive cardiomyopathy.

1975 • 835 citations

Long-term beta-blockade in dilated cardiomyopathy. Effects of short- and long-term metoprolol treatment followed by withdrawal and readministration of metoprolol.

1989 • 447 citations

Improvement in symptoms and exercise tolerance by metoprolol in patients with dilated cardiomyopathy: a double-blind, randomized, placebo-controlled trial.

1985 • 443 citations

Increased beta-receptor density and improved hemodynamic response to catecholamine stimulation during long-term metoprolol therapy in heart failure from dilated cardiomyopathy.

1989 • 429 citations

Effect of propranolol after acute myocardial infarction in patients with congestive heart failure.

1986 • 416 citations

Sample Sizes Based on the Log-Rank Statistic in Complex Clinical Trials

1988 • 330 citations

Effect of metoprolol on myocardial function and energetics in patients with nonischemic dilated cardiomyopathy: A randomized, double-blind, placebo-controlled study

1994 • 318 citations

Unwanted effects of propranolol

1966 • 300 citations

Dose-response of chronic beta-blocker treatment in heart failure from either idiopathic dilated or ischemic cardiomyopathy. Bucindolol Investigators.

1994 • 280 citations

Effect of beta-adrenergic blockade on myocardial function and energetics in congestive heart failure. Improvements in hemodynamic, contractile, and diastolic performance with bucindolol.

1990 • 252 citations

Long-term β-Blocker vasodilator therapy improves cardiac function in idiopathic dilated cardiomyopathy: A double-blind, randomized study of bucindolol versus placebo

1990 • 245 citations

Beta-blockade with bucindolol in heart failure caused by ischemic versus idiopathic dilated cardiomyopathy.

1991 • 232 citations

The β-Blocker Heart Attack Trial

1981 • 226 citations

Role of neurohormonal mechanisms in determining survival in patients with severe chronic heart failure.

1987 • 197 citations

Adverse effects of beta-blockade withdrawal in patients with congestive cardiomyopathy.

1980 • 185 citations

Six-Year Follow-up of the Norwegian Multicenter Study on Timolol after Acute Myocardial Infarction

1985 • 173 citations

Pathophysiologic and pharmacologic rationales for clinical management of chronic heart failure with beta-blocking agents

1993 • 154 citations

Usefulness of bucindolol in congestive heart failure

1990 • 107 citations

Sample size determination in clinical trials with time-dependent rates of losses and noncompliance

1986 • 105 citations

The paradox of β-adrenergic blockade for the management of congestive heart failure

1992 • 102 citations

Receptor Pharmacology of Carvedilol in the Human Heart

1992 • 85 citations

Mechanism of Action of Bucindolol in Human Ventricular Myocardium

1990 • 75 citations

The Lopressor Intervention Trial: Multicentre study of metoprolol in survivors of acute myocardial infarction

1987 • 67 citations

Effects of bucindolol in heart failure

1993 • 22 citations