Transcriptional regulation of Th17 cell differentiation

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2006 • 6,720 citations

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

2006 • 4,815 citations

Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

2005 • 4,573 citations

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

2005 • 4,165 citations

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

2005 • 3,961 citations

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

2006 • 3,545 citations

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

The RXR heterodimers and orphan receptors

1995 • 3,168 citations

Transforming growth factor-β induces development of the TH17 lineage

2006 • 3,014 citations

A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

2006 • 2,903 citations

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

2003 • 2,856 citations

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

2007 • 2,575 citations

Interleukin-17 Family Members and Inflammation

2004 • 2,340 citations

IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

2007 • 2,031 citations

Reciprocal T _H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid

2007 • 1,890 citations

Phenotypic and functional features of human Th17 cells

2007 • 1,832 citations

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

2007 • 1,816 citations

IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

2007 • 1,808 citations

Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells

2007 • 1,773 citations

Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells

2007 • 1,772 citations

Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

2003 • 1,652 citations

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

2007 • 1,446 citations

Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation

2007 • 1,443 citations

STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells

2007 • 1,418 citations

Distinct Effects of T-bet in T _H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells

2002 • 1,169 citations

Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17

2007 • 1,133 citations

A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis

2006 • 987 citations

Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17–producing T cell responses

2007 • 968 citations

Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system

2006 • 947 citations

An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells

2003 • 917 citations

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17–producing T cells

2006 • 831 citations

Interleukin-23 drives innate and T cell–mediated intestinal inflammation

2006 • 814 citations

Requirement for RORγ in Thymocyte Survival and Lymphoid Organ Development

2000 • 714 citations

The development of inflammatory TH-17 cells requires interferon-regulatory factor 4

2007 • 665 citations

Th17: the third member of the effector T cell trilogy

2007 • 642 citations

IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC–activated Th2 memory cells

2007 • 641 citations

Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

2006 • 629 citations

IL-21 Is Produced by Th17 Cells and Drives IL-17 Production in a STAT3-dependent Manner

2007 • 622 citations

Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae

2005 • 598 citations

Expanding the effector CD4 T-cell repertoire: the Th17 lineage

2006 • 595 citations

IL-23 plays a key role inHelicobacter hepaticus–induced T cell–dependent colitis

2006 • 570 citations

IL‐23 and the Th17 pathway promote inflammation and impair antifungal immune resistance

2007 • 550 citations

Cutting Edge: Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STAT1 During Initial Th1 Commitment

2003 • 534 citations

Thymic Origin of Intestinal αß T Cells Revealed by Fate Mapping of RORγt ⁺ Cells

2004 • 482 citations

Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice

2007 • 477 citations

The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs

2005 • 439 citations

Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation

2005 • 428 citations

Signals mediated by transforming growth factor-β initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease

2006 • 392 citations

IL-25 regulates Th17 function in autoimmune inflammation

2007 • 384 citations

T Helper Cell Differentiation: Regulation by cis Elements and Epigenetics

2006 • 315 citations

Chromatin Remodeling of Interleukin-17 (IL-17)-IL-17F Cytokine Gene Locus during Inflammatory Helper T Cell Differentiation

2007 • 296 citations

Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-γ

2007 • 289 citations

T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17

2006 • 259 citations

RORγt, a Novel Isoform of an Orphan Receptor, Negatively Regulates Fas Ligand Expression and IL-2 Production in T Cells

1998 • 235 citations

The ROR nuclear orphan receptor subfamily: Critical regulators of multiple biological processes

2001 • 227 citations

An Indispensable Role for STAT1 in IL-27-Induced T-bet Expression but Not Proliferation of Naive CD4+ T Cells

2004 • 223 citations

ROR-γ: The Third Member of ROR/RZR Orphan Receptor Subfamily That Is Highly Expressed in Skeletal Muscle

1994 • 211 citations

Biology of IL‐21 and the IL‐21 receptor

2004 • 196 citations

The role of the nuclear hormone receptor RORγt in the development of lymph nodes and Peyer's patches

2003 • 193 citations

Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-γ during the differentiation of T helper type 2 cells

2007 • 168 citations

CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation

2007 • 161 citations

T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype

2006 • 148 citations

Cloning of a cDNA encoding the murine orphan receptor RZR/RORγ and characterization of its response element

1996 • 123 citations

Roles of αv integrins in vascular biology and pulmonary pathology

2004 • 93 citations

Genomic Structure and Chromosomal Mapping of the Nuclear Orphan Receptor RORγ (RORC) Gene

1997 • 60 citations

Oral tolerance: Passing CD11b on the way to tolerance

2007 • 6 citations