The role of the nuclear hormone receptor RORγt in the development of lymph nodes and Peyer's patches

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

1999 • 3,340 citations

The protein Id: A negative regulator of helix-loop-helix DNA binding proteins

1990 • 2,273 citations

The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator

2002 • 2,045 citations

Prox1 Function Is Required for the Development of the Murine Lymphatic System

1999 • 1,525 citations

RANK is essential for osteoclast and lymph node development

1999 • 1,417 citations

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

2001 • 1,333 citations

NFAT Signaling

2002 • 1,316 citations

A chemokine-driven positive feedback loop organizes lymphoid follicles

2000 • 1,220 citations

Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice

1995 • 1,167 citations

A Putative Chemokine Receptor, BLR1, Directs B Cell Migration to Defined Lymphoid Organs and Specific Anatomic Compartments of the Spleen

1996 • 1,125 citations

An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype

2002 • 894 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways

2002 • 891 citations

A transcription factor response element for gene expression during circadian night

2002 • 852 citations

Development of peripheral lymphoid organs and natural killer cells depends on the helix–loop–helix inhibitor Id2

1999 • 841 citations

Requirement for RORγ in Thymocyte Survival and Lymphoid Organ Development

2000 • 714 citations

The Lymphotoxin β Receptor Controls Organogenesis and Affinity Maturation in Peripheral Lymphoid Tissues

1998 • 710 citations

Developing Lymph Nodes Collect CD4 + CD3 − LTβ + Cells That Can Differentiate to APC, NK Cells, and Follicular Cells but Not T or B Cells

1997 • 654 citations

Severe osteopetrosis, defective interleukin‐1 signalling and lymph node organogenesis in TRAF6‐deficient mice

1999 • 639 citations

TRANCE, a TNF Family Member, Activates Akt/PKB through a Signaling Complex Involving TRAF6 and c-Src

1999 • 583 citations

On the origin of the lymphatic system from the veins and the development of the lymph hearts and thoracic duct in the pig

1902 • 542 citations

Disruption of the nuclear hormone receptor RORα in staggerer mice

1996 • 478 citations

Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily.

1994 • 434 citations

Melatonin receptors step into the light: cloning and classification of subtypes

1996 • 422 citations

Identification of committed NK cell progenitors in adult murine bone marrow

2001 • 345 citations

A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice

1994 • 327 citations

Retinoid-related orphan receptor γ (RORγ) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis

2000 • 308 citations

The lymphatic system in human embryos, with a consideration of the morphology of the system as a whole

1909 • 292 citations

IL-7 receptor α+ CD3– cells in the embryonic intestine induces the organizing center of Peyer's patches

1999 • 289 citations

X-Ray Structure of the hRORα LBD at 1.63 Å

2002 • 285 citations

staggerer phenotype in retinoid-related orphan receptor α-deficient mice

1998 • 272 citations

Overlapping Roles of CXCL13, Interleukin 7 Receptor α, and CCR7 Ligands in Lymph Node Development

2003 • 244 citations

Transcriptional activation of the nuclear receptor RZRα by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand

1995 • 244 citations

RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers.

1994 • 242 citations

A developmental switch in lymphocyte homing receptor and endothelial vascular addressin expression regulates lymphocyte homing and permits CD4+ CD3- cells to colonize lymph nodes.

1996 • 240 citations

The Fetal Liver Counterpart of Adult Common Lymphoid Progenitors Gives Rise to All Lymphoid Lineages, CD45+CD4+CD3− Cells, As Well As Macrophages

2001 • 240 citations

Different Cytokines Induce Surface Lymphotoxin-αβ on IL-7 Receptor-α Cells that Differentially Engender Lymph Nodes and Peyer's Patches

2002 • 240 citations

RORγt, a Novel Isoform of an Orphan Receptor, Negatively Regulates Fas Ligand Expression and IL-2 Production in T Cells

1998 • 235 citations

Molecular Basis for Hematopoietic/Mesenchymal Interaction during Initiation of Peyer's Patch Organogenesis

2001 • 231 citations

The ROR nuclear orphan receptor subfamily: Critical regulators of multiple biological processes

2001 • 227 citations

Regulation of the TCRα repertoire by the survival window of CD4+CD8+ thymocytes

2002 • 227 citations

Thymocyte Selection Is Regulated by the Helix-Loop-Helix Inhibitor Protein, Id3

2000 • 220 citations

Disruption of retinoid-related orphan receptor β changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice

1998 • 214 citations

Initiation of NALT Organogenesis Is Independent of the IL-7R, LTβR, and NIK Signaling Pathways but Requires the Id2 Gene and CD3−CD4+CD45+ Cells

2002 • 212 citations

ROR-γ: The Third Member of ROR/RZR Orphan Receptor Subfamily That Is Highly Expressed in Skeletal Muscle

1994 • 211 citations

Id and development

2001 • 208 citations

Three distinctive steps in Peyer's patch formation of murine embryo

1997 • 205 citations

CD4+CD3− Cells Induce Peyer's Patch Development

2002 • 194 citations

A link between cell cycle and cell death: Bax and Bcl-2 modulate Cdk2 activation during thymocyte apoptosis

1998 • 192 citations

Expression patterns ofId1, Id2, andId3 are highly related but distinct from that ofId4 during mouse embryogenesis

1996 • 184 citations

The orphan receptor family RZR/ROR, melatonin and 5‐lipoxygenase: An unexpected relationship

1995 • 180 citations

Essential role of IL-7 receptor alpha in the formation of Peyer's patch anlage

1998 • 161 citations

Defect in Rearrangement of the Most 5′ TCR–Jα Following Targeted Deletion of T Early α (TEA): Implications for TCR α Locus Accessibility

1996 • 158 citations

The ExDression Pattern of the Orphan Nuclear Receptor RORβ in the Developing and Adult Rat Nervous System Suggests a Role in the Processing of Sensory Information and in Circadian Rhythm

1997 • 155 citations

Neural Crest Specification Regulated by the Helix-Loop-Helix Repressor Id2

1998 • 141 citations

Expression of α4β7 Integrin Defines a Distinct Pathway of Lymphoid Progenitors Committed to T Cells, Fetal Intestinal Lymphotoxin Producer, NK, and Dendritic Cells

2001 • 138 citations

Cloning of a cDNA encoding the murine orphan receptor RZR/RORγ and characterization of its response element

1996 • 123 citations

On the development of the superficial lymphatics in the skin of the pig

1904 • 122 citations

BCL-xL and BCL2 delay Myc-induced cell cycle entry through elevation of p27 and inhibition of G1 cyclin-dependent kinases

2002 • 117 citations

The mt1 Melatonin Receptor and RORβ Receptor Are Co-localized in Specific TSH-immunoreactive Cells in the Pars Tuberalis of the Rat Pituitary

2002 • 116 citations

RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers

1994 • 116 citations

In vitro and in vivo evidence for orphan nuclear receptor RORα function in bone metabolism

2000 • 115 citations

Requirement for the NF-κB Family Member RelA in the Development of Secondary Lymphoid Organs

2002 • 105 citations

A novel isoform of the orphan nuclear receptor RORβ is specifically expressed in pineal gland and retina

1998 • 100 citations

The role of CD45⁺CD4⁺CD3^– cells in lymphoid organ development

2002 • 87 citations

RORγT, a thymus-specific isoform of the orphan nuclear receptor RORγ / TOR, is up-regulated by signaling through the pre-T cell receptor and binds to the TEA promoter

1999 • 77 citations

Genomic Structure and Chromosomal Mapping of the Nuclear Orphan Receptor RORγ (RORC) Gene

1997 • 60 citations

The histogenesis of lymph nodes in rat and rabbit

1978 • 55 citations

Ontogeny of human fetal lymph nodes

1975 • 43 citations

Role of the Nuclear Hormone Receptor ROR in Transcriptional Regulation, Thymocyte Survival, and Lymphoid Organogenesis

1999 • 39 citations

Immunologic abnormalities of mice bearing the gld mutation suggest a common pathway for murine nonmalignant lymphoproliferative disorders with autoimmunity.

1985 • 33 citations

Symposium on the development and structure of the lymphatic system. III. Further evidence on the origin of the lymphatic endothelium from the endothelium of the blood vascular system

1908 • 27 citations