Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-γ during the differentiation of T helper type 2 cells
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References (53)
The language of covalent histone modifications
2000 • 8,260 citations
A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells
2006 • 5,132 citations
Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes
2005 • 3,888 citations
A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
2000 • 3,456 citations
The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells
1997 • 2,317 citations
Active genes are tri-methylated at K4 of histone H3
2002 • 2,064 citations
Histone modifications in transcriptional regulation
2002 • 1,200 citations
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
1996 • 1,182 citations
Cellular Memory and the Histone Code
2002 • 1,137 citations
Epigenetic Regulation of Cellular Memory by the Polycomb and Trithorax Group Proteins
2004 • 1,049 citations
Molecular Mechanisms RegulatinG Th1 Immune Responses
2003 • 1,005 citations
A Hidden Markov Model approach to variation among sites in rate of evolution
1996 • 839 citations
Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism
1998 • 800 citations
The key to development: interpreting the histone code?
2005 • 729 citations
Modulation of Chromatin Structure Regulates Cytokine Gene Expression during T Cell Differentiation
1998 • 697 citations
Histone H3 Lysine 9 Methylation and HP1γ Are Associated with Transcription Elongation through Mammalian Chromatin
2005 • 690 citations
The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation
2004 • 581 citations
TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes
2002 • 517 citations
T Helper Cell Fate Specified by Kinase-Mediated Interaction of T-bet with GATA-3
2005 • 505 citations
Early Transcription and Silencing of Cytokine Genes Underlie Polarization of T Helper Cell Subsets
2001 • 498 citations
Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain
1996 • 483 citations
An epigenetic view of helper T cell differentiation
2003 • 429 citations
Regulation of Transcription Factor YY1 by Acetylation and Deacetylation
2001 • 405 citations
Silencing by plant Polycomb-group genes requires dispersed trimethylation of histone H3 at lysine 27
2006 • 405 citations
Histone trimethylation and the maintenance of transcriptional ONand OFF states by trxG and PcG proteins
2006 • 397 citations
Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3
2004 • 351 citations
T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription
2006 • 326 citations
Cutting Edge: Changes in Histone Acetylation at the IL-4 and IFN-γ Loci Accompany Th1/Th2 Differentiation
2002 • 326 citations
T Helper Cell Differentiation: Regulation by cis Elements and Epigenetics
2006 • 315 citations
Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S.cerevisiae telomeres
1997 • 277 citations
Conserved non-genic sequences — an unexpected feature of mammalian genomes
2005 • 264 citations
Developmentally dynamic histone acetylation pattern of a tissue-specific chromatin domain
2000 • 228 citations
Identification of a Conserved GATA3 Response Element Upstream Proximal from the Interleukin-13 Gene Locus
2002 • 194 citations
A Distal Conserved Sequence Element Controls Ifng Gene Expression by T Cells and NK Cells
2006 • 182 citations
Distinct Contributions of Histone H3 Lysine 9 and 27 Methylation to Locus-Specific Stability of Polycomb Complexes
2004 • 176 citations
The Nuclear Factor YY1 Suppresses the Human Gamma Interferon Promoter through Two Mechanisms: Inhibition of AP1 Binding and Activation of a Silencer Element
1996 • 171 citations
EZH2 and Histone 3 Trimethyl Lysine 27 Associated with Il4 and Il13 Gene Silencing in TH1 Cells
2005 • 153 citations
Histone acetylation beyond promoters: long‐range acetylation patterns in the chromatin world*
2001 • 150 citations
A Distal Enhancer in the Interferon-γ (IFN-γ) Locus Revealed by Genome Sequence Comparison
2004 • 137 citations
Evolutionarily conserved sequence elements that positively regulate IFN-γ expression in T cells
2004 • 134 citations
Dynamic assembly of silent chromatin during thymocyte maturation
2004 • 132 citations
Polycomb Complexes and the Propagation of the Methylation Mark at the Drosophila Ubx Gene
2006 • 106 citations
Architecture of a Polycomb Nucleoprotein Complex
2006 • 96 citations
Chromatin landscape dynamics of theIl4–Il13locus during T helper 1 and 2 development
2004 • 96 citations
Histone hyperacetylated domains across the Ifng gene region in natural killer cells and T cells
2005 • 91 citations
Synergistic Effect of IL-2, IL-12, and IL-18 on Thymocyte Apoptosis and Th1/Th2 Cytokine Expression
2005 • 64 citations
Long-range histone acetylation of the Ifng gene is an essential feature of T cell differentiation
2004 • 63 citations
Dynamic alterations in the conformation of the Ifng gene region during T helper cell differentiation
2003 • 59 citations
Cutting Edge: Distal Regulatory Elements Are Required to Achieve Selective Expression of IFN-γ in Th1/Tc1 Effector Cells
2002 • 50 citations
Cracking the Histone Code One, Two, Three Methyls, You're Out!
2003 • 48 citations
A Minimal IFN-γ Promoter Confers Th1 Selective Expression
2002 • 46 citations
Long-range histone acetylation: biological significance, structural implications, and mechanismsThis paper is one of a selection of papers published in this Special Issue, entitled 27th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.
2006 • 40 citations
Chromatin structure and gene regulation in T cell development and function
2006 • 34 citations