Back to search

Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-γ during the differentiation of T helper type 2 cells

Data up to Jan 2025

Published2007
Citations168
References53

Total Citations Per Year

Abstract

References (53)

The language of covalent histone modifications

2000 • 8,260 citations

A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells

2006 • 5,132 citations

Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes

2005 • 3,888 citations

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

Active genes are tri-methylated at K4 of histone H3

2002 • 2,064 citations

Histone modifications in transcriptional regulation

2002 • 1,200 citations

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1996 • 1,182 citations

Cellular Memory and the Histone Code

2002 • 1,137 citations

Epigenetic Regulation of Cellular Memory by the Polycomb and Trithorax Group Proteins

2004 • 1,049 citations

Molecular Mechanisms RegulatinG Th1 Immune Responses

2003 • 1,005 citations

A Hidden Markov Model approach to variation among sites in rate of evolution

1996 • 839 citations

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1998 • 800 citations

The key to development: interpreting the histone code?

2005 • 729 citations

Modulation of Chromatin Structure Regulates Cytokine Gene Expression during T Cell Differentiation

1998 • 697 citations

Histone H3 Lysine 9 Methylation and HP1γ Are Associated with Transcription Elongation through Mammalian Chromatin

2005 • 690 citations

The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation

2004 • 581 citations

TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes

2002 • 517 citations

T Helper Cell Fate Specified by Kinase-Mediated Interaction of T-bet with GATA-3

2005 • 505 citations

Early Transcription and Silencing of Cytokine Genes Underlie Polarization of T Helper Cell Subsets

2001 • 498 citations

Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain

1996 • 483 citations

An epigenetic view of helper T cell differentiation

2003 • 429 citations

Regulation of Transcription Factor YY1 by Acetylation and Deacetylation

2001 • 405 citations

Silencing by plant Polycomb-group genes requires dispersed trimethylation of histone H3 at lysine 27

2006 • 405 citations

Histone trimethylation and the maintenance of transcriptional ONand OFF states by trxG and PcG proteins

2006 • 397 citations

Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3

2004 • 351 citations

T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription

2006 • 326 citations

Cutting Edge: Changes in Histone Acetylation at the IL-4 and IFN-γ Loci Accompany Th1/Th2 Differentiation

2002 • 326 citations

T Helper Cell Differentiation: Regulation by cis Elements and Epigenetics

2006 • 315 citations

Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S.cerevisiae telomeres

1997 • 277 citations

Conserved non-genic sequences — an unexpected feature of mammalian genomes

2005 • 264 citations

Developmentally dynamic histone acetylation pattern of a tissue-specific chromatin domain

2000 • 228 citations

Identification of a Conserved GATA3 Response Element Upstream Proximal from the Interleukin-13 Gene Locus

2002 • 194 citations

A Distal Conserved Sequence Element Controls Ifng Gene Expression by T Cells and NK Cells

2006 • 182 citations

Distinct Contributions of Histone H3 Lysine 9 and 27 Methylation to Locus-Specific Stability of Polycomb Complexes

2004 • 176 citations

The Nuclear Factor YY1 Suppresses the Human Gamma Interferon Promoter through Two Mechanisms: Inhibition of AP1 Binding and Activation of a Silencer Element

1996 • 171 citations

EZH2 and Histone 3 Trimethyl Lysine 27 Associated with Il4 and Il13 Gene Silencing in TH1 Cells

2005 • 153 citations

Histone acetylation beyond promoters: long‐range acetylation patterns in the chromatin world*

2001 • 150 citations

A Distal Enhancer in the Interferon-γ (IFN-γ) Locus Revealed by Genome Sequence Comparison

2004 • 137 citations

Evolutionarily conserved sequence elements that positively regulate IFN-γ expression in T cells

2004 • 134 citations

Dynamic assembly of silent chromatin during thymocyte maturation

2004 • 132 citations

Polycomb Complexes and the Propagation of the Methylation Mark at the Drosophila Ubx Gene

2006 • 106 citations

Architecture of a Polycomb Nucleoprotein Complex

2006 • 96 citations

Chromatin landscape dynamics of theIl4Il13locus during T helper 1 and 2 development

2004 • 96 citations

Histone hyperacetylated domains across the Ifng gene region in natural killer cells and T cells

2005 • 91 citations

Synergistic Effect of IL-2, IL-12, and IL-18 on Thymocyte Apoptosis and Th1/Th2 Cytokine Expression

2005 • 64 citations

Long-range histone acetylation of the Ifng gene is an essential feature of T cell differentiation

2004 • 63 citations

Dynamic alterations in the conformation of the Ifng gene region during T helper cell differentiation

2003 • 59 citations

Cutting Edge: Distal Regulatory Elements Are Required to Achieve Selective Expression of IFN-γ in Th1/Tc1 Effector Cells

2002 • 50 citations

Cracking the Histone Code One, Two, Three Methyls, You're Out!

2003 • 48 citations

A Minimal IFN-γ Promoter Confers Th1 Selective Expression

2002 • 46 citations

Long-range histone acetylation: biological significance, structural implications, and mechanismsThis paper is one of a selection of papers published in this Special Issue, entitled 27th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.

2006 • 40 citations

Chromatin structure and gene regulation in T cell development and function

2006 • 34 citations

Cited By (0)

Loading...
Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-γ… (2007) – Nature Immunology | Metascience Observatory Explorer