Functional aspects of the X-ray structure of mitochondrial creatine kinase: a molecular physiology approach.

Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features

1983 • 14,802 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

RASMOL: biomolecular graphics for all

1995 • 2,601 citations

Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the ‘phosphocreatine circuit’ for cellular energy homeostasis

1992 • 1,958 citations

Progress in Clinical and Biological Research

1979 • 1,317 citations

Transport of Energy in Muscle: The Phosphorylcreatine Shuttle

1981 • 748 citations

THE CREATINE-CREATINE PHOSPHATE ENERGY SHUTTLE

1985 • 746 citations

Three-dimensional structure of the tryptophan synthase alpha 2 beta 2 multienzyme complex from Salmonella typhimurium.

1988 • 706 citations

A simple analysis of the "phosphocreatine shuttle"

1984 • 503 citations

Creatine Kinase of Rat Heart Mitochondria

1973 • 467 citations

Mitochondrial creatine kinase: a key enzyme of aerobic energy metabolism

1992 • 439 citations

ADENOSINETRIPHOSPHATE-CREATINE TRANSPHOSPHORYLASE

1954 • 396 citations

Creatine kinase in non-muscle tissues and cells

1994 • 372 citations

High activity of creatine kinase in mitochondria from muscle and brain and evidence for a separate mitochondrial isoenzyme of creatine kinase

1964 • 341 citations

Complexes between kinases, mitochondrial porin and adenylate translocator in rat brain resemble the permeability transition pore

1996 • 336 citations

Role of creatine phosphokinase in cellular function and metabolism

1978 • 298 citations

ADP/ATP carrier protein from beef heart mitochondria has high amounts of tightly bound cardiolipin, as revealed by phosphorus-31 nuclear magnetic resonance

1985 • 296 citations

Structure of mitochondrial creatine kinase

1996 • 291 citations

The ontogeny of creatine kinase isozymes

1964 • 259 citations

Open "Back Door" in a Molecular Dynamics Simulation of Acetylcholinesterase

1994 • 259 citations

Altered Ca2+ Responses in Muscles with Combined Mitochondrial and Cytosolic Creatine Kinase Deficiencies

1997 • 250 citations

Metabolic compartmentation and substrate channelling in muscle cells

1994 • 241 citations

ADENOSINETRIPHOSPHATE-CREATINE TRANSPHOSPHORYLASE

1954 • 239 citations

A Protein That Binds Specifically to the M-Line of Skeletal Muscle Is Identified as the Muscle Form of Creatine Kinase

1973 • 238 citations

Muscle-type MM creatine kinase is specifically bound to sarcoplasmic reticulum and can support Ca2+ uptake and regulate local ATP/ADP ratios.

1990 • 207 citations

Inhibition of adenosine 5′-triphosphate–creatine phosphotransferase by substrate–anion complexes. Evidence for the transition-state organization of the catalytic site

1971 • 191 citations

Creatine kinase of rat heart mitochondria. The demonstration of functional coupling to oxidative phosphorylation in an inner membrane-matrix preparation.

1985 • 186 citations

Cell and Muscle Motility

1982 • 185 citations

Native mitochondrial creatine kinase forms octameric structures. I. Isolation of two interconvertible mitochondrial creatine kinase forms, dimeric and octameric mitochondrial creatine kinase: characterization, localization, and structure-function relationships.

1988 • 167 citations

Sequence homology and structure predictions of the creatine kinase isoenzymes

1994 • 158 citations

Localization and Function of M-Line-Bound Creatine Kinase

1985 • 158 citations

The possible role of the mitochondrial bound creatine kinase in regulation of mitochondrial respiration

1966 • 158 citations

Localization of creatine kinase isoenzymes in myofibrils. II. Chicken heart muscle.

1977 • 152 citations

Non-bilayer lipids are required for efficient protein transport across the plasma membrane of Escherichia coli.

1995 • 144 citations

Cardiolipin is the membrane receptor for mitochondrial creatine phosphokinase.

1985 • 140 citations

Studies on adenosine triphosphate transphosphorylases

1972 • 131 citations

Bioenergetics: Dissecting the role of creatine kinase

1994 • 127 citations

Creatine kinase: The reactive cysteine is required for synergism but is nonessential for catalysis

1993 • 117 citations

Is myosin a "back door" enzyme?

1995 • 111 citations

Compartmentalized energy transfer in cardiomyocytes: use of mathematical modeling for analysis of in vivo regulation of respiration

1997 • 110 citations

Use of pH studies to elucidate the catalytic mechanism of rabbit muscle creatine kinase

1981 • 107 citations

Metabolic compartmentation and substrate channelling in muscle cells

1994 • 104 citations

Functional coupling between sarcoplasmic‐reticulum‐bound creatine kinase and Ca²⁺‐ATPase

1993 • 103 citations

In vitro complex formation between the octamer of mitochondrial creatine kinase and porin.

1994 • 98 citations

Creatine kinase (CK) in skeletal muscle energy metabolism: a study of mouse mutants with graded reduction in muscle CK expression.

1994 • 98 citations

Dynamic compartmentation of adenine nucleotides in the mitochondrial intermembrane space of rat-heart mitochondria

1987 • 97 citations

Why do cells need phosphocreatine and a phosphocreatine shuttle

1987 • 95 citations

Suppression of Creatine Kinase-catalyzed Phosphotransfer Results in Increased Phosphoryl Transfer by Adenylate Kinase in Intact Skeletal Muscle

1996 • 95 citations

Native mitochondrial creatine kinase forms octameric structures. II. Characterization of dimers and octamers by ultracentrifugation, direct mass measurements by scanning transmission electron microscopy, and image analysis of single mitochondrial creatine kinase octamers.

1988 • 94 citations

Activity of creatine kinase in a contracting mammalian muscle of uniform fiber type

1994 • 90 citations

Phosphocreatine protects transgenic mouse liver expressing creatine kinase from hypoxia and ischemia

1993 • 86 citations

Location and regulation of octameric mitochondrial creatine kinase in the contact sites

1991 • 85 citations

The transmembrane arrangement of the ADP/ATP carrier as elucidated by the lysine reagent pyridoxal 5‐phosphate

1986 • 80 citations

Ca2+ uptake by cardiac sarcoplasmic reticulum ATPase in situ strongly depends on bound creatine kinase

1996 • 78 citations

Channelling in Intermediary Metabolism

1996 • 69 citations

A Membrane-bound Creatine Phosphokinase in Fragmented Sarcoplasmic Reticulum

1970 • 68 citations

Transmembrane arrangement of mitochondrial porin or voltage-dependent anion channel (VDAC)

1992 • 66 citations

Creatine Kinase Equilibration Follows Solution Thermodynamics in Skeletal Muscle.

1995 • 65 citations

Further observations on phosphagen

1928 • 64 citations

Energy transport from mitochondria to myofibril by a creatine phosphate shuttle in cardiac cells

1983 • 64 citations

The tryptophan residues of mitochondrial creatine kinase: Roles of Trp‐223, Trp‐206, and Trp‐264 in active‐site and quaternary structure formation

1994 • 63 citations

Structure of the mitochondrial creatine kinase octamer: high-resolution shadowing and image averaging of single molecules and formation of linear filaments under specific staining conditions.

1991 • 62 citations

Creatine kinase. Nuclear magnetic resonance and fluorescence evidence for interaction of adenosine 5'-diphosphate with aromatic residue(s)

1979 • 59 citations

Cell Architecture and Metabolic Channeling

1995 • 58 citations

The utilisation of creatine and its analogues by cytosolic and mitochondrial creatine kinase

1996 • 58 citations

The active site of creatine kinase. Affinity labeling of cysteine 282 with N-(2,3-epoxypropyl)-N-amidinoglycine.

1992 • 58 citations

Interaction of mitochondrial creatine kinase with model membranes A monolayer study

1991 • 54 citations

Subcellular compartmentation of creatine kinase isoenzymes, regulation of CK and octameric structure of mitochondrial CK: important aspects of the phosphoryl-creatine circuit.

1989 • 54 citations

The Role of Creatine Phosphokinase in Supplying Energy for the Calcium Pump System of Heart Sarcoplasmic Reticulum

1978 • 52 citations

Phosphocreatine protects ATP from a fructose load in transgenic mouse liver expressing creatine kinase

1991 • 50 citations

Metabolite status of the heart in acute insufficiency due to 1-fluoro-2,4-dinitrobenzene

1968 • 49 citations

Identification and primary structure of the cardiolipin‐binding domain of mitochondrial creatine kinase

1988 • 48 citations

Muskelmitochondrien

1964 • 48 citations

Regulation of creatine phosphokinase B activity by protein kinase C

1990 • 47 citations

Specific inhibition of ATP-ADP translocase in cardiac mitoplasts by antibodies against mitochondrial creatine kinase

1987 • 46 citations

Rabbit Muscle Creatine Kinase: Consequences of the Mutagenesis of Conserved Histidine Residues

1996 • 45 citations

Expression of active octameric chicken cardiac mitochondrial creatine kinase in Escherichia coli

1992 • 45 citations

The N-terminal heptapeptide of mitochondrial creatine kinase is important for octamerization

1994 • 43 citations

31P-NMR-measured creatine kinase reaction flux in muscle: a caveat!

1996 • 43 citations

Membrane-Binding and Lipid Vesicle Cross-Linking Kinetics of the Mitochondrial Creatine Kinase Octamer

1996 • 43 citations

Nuclear magnetic resonance studies of the role of histidine residues at the active site of rabbit muscle creatine kinase

1981 • 43 citations

Kinetic Characterization of Channel Impaired Mutants of Tryptophan Synthase

1995 • 42 citations

Crystallization of mitochondrial creatine kinase. Growing of large protein crystals and electron microscopic investigation of microcrystals consisting of octamers.

1991 • 42 citations

Evaluation of Creatine Analogues as a New Class of Anticancer Agents Using Freshly Explanted Human Tumor Cells

1994 • 41 citations

Re-evaluation of the structure and physiological function of guanidino kinases in fruitfly (Drosophila), sea urchin (Psammechinus miliaris) and man

1995 • 41 citations

Energy metabolism and regeneration in transgenic mouse liver expressing creatine kinase after major hepatectomy

1996 • 39 citations

Kinetics of assembly and dissociation of the mitochondrial creatine kinase octamer. A fluorescence study

1993 • 39 citations

Activation of sea-urchin sperm motility is accompanied by an increase in the creatine kinase exchange flux

1997 • 38 citations

Mitochondrial Creatine Kinase Interaction with Phospholipid Vesicles

1997 • 37 citations

Limited proteolysis of creatine kinase. Implications for three-dimensional structure and for conformational substates

1993 • 37 citations

Functions of Creatine Kinase Isoenzymes in Spermatozoa

1997 • 37 citations

Interaction of phospholipids with the detergent-solubilized ADP/ATP carrier protein as studied by spin-label electron spin resonance

1988 • 35 citations

Association of chicken mitochondrial creatine kinase with the inner mitochondrial membrane

1987 • 34 citations

Cellular Bioenergetics: Role of Coupled Creatine Kinases

1994 • 34 citations

Ergebnisse der Physiologie Biologischen Chemie und Experimentellen Pharmakologie

1944 • 33 citations

Cyclocreatine in cancer chemotherapy

1995 • 31 citations

Crystallization of Mitochondrial Creatine Kinase on Negatively Charged Lipid Layers

1994 • 31 citations

Adenosine triphosphate transphosphorylases. VII. Isolation of the crystalline adenosine triphosphate-creatine transphosphorylase from calf brain

1968 • 30 citations

A spin‐label electron spin resonance study of the binding of mitochondrial creatine kinase to cardiolipin

1989 • 29 citations

Tryptophan residues of creatine kinase: a fluorescence study

1985 • 28 citations

Changes of creatine kinase structure upon ligand binding as seen by small-angle scattering

1996 • 27 citations

A preliminary crystallographic investigation of rabbit muscle creatine kinase

1973 • 27 citations

The active site histidines of creatine kinase. A critical role of His 61 situated on a flexible loop

1997 • 27 citations

Balancing ATP in the cell

1996 • 27 citations

Expression, purification from inclusion bodies, and crystal characterization of a transition state analog complex of arginine kinase: A model for studying phosphagen kinases

1997 • 26 citations

The radiation inactivation method provides evidence that membrane-bound mitochondrial creatine kinase is an oligomer

1988 • 25 citations

Reconstitution of active octameric mitochondrial creatine kinase from two genetically engineered fragments

1996 • 24 citations

Purification and crystallization of creatine kinase from rabbit skeletal muscle.

1986 • 23 citations

Die Bedeutung von Kreatinphosphat und Adenosintriphosphat im Hinblick auf Energiebereitstellung, -transport und -verwertung im normalen und insuffizienten Herzmuskel

1970 • 23 citations

Effect of okadaic acid on protein phosphorylation patterns of chicken myogenic cells with special reference to creatine kinase

1993 • 23 citations

Differences in nucleotide compartmentation and energy state in isolated and in situ rat heart: Assessment by 31P-NMR spectroscopy

1996 • 22 citations

Interaction of creatine kinase and hexokinase with the mitochondrial membranes, and self-association of creatine kinase: crosslinking studies

1987 • 20 citations

Crystallization and preliminary X-ray analysis of two different forms of mitochondrial creatine kinase from chicken cardiac muscle

1990 • 19 citations

The structure of mitochondrial creatine kinase and its membrane binding properties

1994 • 19 citations

The activity of S-thiomethyl modified creatine kinase is due to the regeneration of free thiol at the active site

1994 • 18 citations

Crystallization and preliminary X-ray diffraction data of two crystal forms of bovine heart creatine kinase

1983 • 18 citations

Identification by protein microsequencing of a proteinase-V8-cleavage site in a folding intermediate of chick muscle creatine kinase

1991 • 15 citations

Creatine kinase. A new crystal form providing evidence of subunit structural homogeneity

1978 • 15 citations

Cause and consequences of dynamic compartmentation of adenine nucleotides in the mitochondrial intermembrane space in respect to exchange of energy rich phosphates between cytosol and mitochondria.

1987 • 12 citations

Crystallization and Properties of Creatine Kinase from Equine Skeletal Muscle

1981 • 9 citations

A model of mitochondrial creatine kinase binding to membranes: adsorption constants, essential amino acids and the effect of ionic strength

1993 • 9 citations

Creatinkinase-Isoenzyme und Myofibrillen-Struktur

1975 • 3 citations

Some evidence in favour of the partnership between rabbit muscle aldolase and glyceraldehyde 3-phosphate dehydrogenase in the consecutive reactions.

1994 • 2 citations

Deleted Work

1955 • 0 citations