Functions of Creatine Kinase Isoenzymes in Spermatozoa

Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the ‘phosphocreatine circuit’ for cellular energy homeostasis

1992 • 1,958 citations

Male Reproductive Function and Semen

1981 • 1,107 citations

Physiology and biochemistry of the domestic fowl

1985 • 1,091 citations

Transport of Energy in Muscle: The Phosphorylcreatine Shuttle

1981 • 748 citations

THE CREATINE-CREATINE PHOSPHATE ENERGY SHUTTLE

1985 • 746 citations

FLAGELLAR MOVEMENT AND ADENOSINE TRIPHOSPHATASE ACTIVITY IN SEA URCHIN SPERM EXTRACTED WITH TRITON X-100

1972 • 567 citations

A simple analysis of the "phosphocreatine shuttle"

1984 • 503 citations

Mitochondrial creatine kinase: a key enzyme of aerobic energy metabolism

1992 • 439 citations

Development of an Image Analysis System to Monitor the Retention of Residual Cytoplasm by Human Spermatozoa: Correlation With Biochemical Markers of the Cytoplasmic Space, Oxidative Stress, and Sperm Function

1996 • 379 citations

Creatine kinase in non-muscle tissues and cells

1994 • 372 citations

Skeletal muscles of mice deficient in muscle creatine kinase lack burst activity

1993 • 334 citations

Role of creatine phosphokinase in cellular function and metabolism

1978 • 298 citations

Structure of mitochondrial creatine kinase

1996 • 291 citations

Metabolite channeling: A phosphorylcreatine shuttle to mediate high energy phosphate transport between sperm mitochondrion and tail

1985 • 247 citations

Respiratory Control and the Integration of Heart High-Energy Phosphate Metabolism by Mitochondrial Creatine Kinase

1985 • 241 citations

High‐pressure freezing of cell suspensions in cellulose capillary tubes

1994 • 237 citations

Form and Function in Birds.

1981 • 217 citations

Elevation of the intracellular pH activates respiration and motility of sperm of the sea urchin, Strongylocentrotus purpuratus.

1982 • 215 citations

Muscle-type MM creatine kinase is specifically bound to sarcoplasmic reticulum and can support Ca2+ uptake and regulate local ATP/ADP ratios.

1990 • 207 citations

Function of M-line-bound creatine kinase as intramyofibrillar ATP regenerator at the receiving end of the phosphorylcreatine shuttle in muscle.

1984 • 193 citations

Metabolism of sea urchin sperm. Interrelationships between intracellular pH, ATPase activity, and mitochondrial respiration.

1983 • 187 citations

Studies on Adenosine Triphosphate Transphosphorylases

1962 • 186 citations

p95, the major phosphotyrosine-containing protein in mouse spermatozoa, is a hexokinase with unique properties.

1994 • 178 citations

Native mitochondrial creatine kinase forms octameric structures. I. Isolation of two interconvertible mitochondrial creatine kinase forms, dimeric and octameric mitochondrial creatine kinase: characterization, localization, and structure-function relationships.

1988 • 167 citations

Sperm Plasma Membrane Remodeling during Spermiogenetic Maturation in Men: Relationship among Plasma Membrane β 1,4-Galactosyltransferase, Cytoplasmic Creatine Phosphokinase, and Creatine Phosphokinase Isoform Ratios1

1997 • 161 citations

Localization and Function of M-Line-Bound Creatine Kinase

1985 • 158 citations

Biochemical evolution and the origin of life

1972 • 156 citations

Evolution of Phosphagen Kinase

1994 • 149 citations

Glyceraldehyde 3-phosphate dehydrogenase is bound to the fibrous sheath of mammalian spermatozoa

1997 • 148 citations

Incomplete development of human spermatozoa is associated with increased creatine phosphokinase concentration and abnormal head morphology

1993 • 148 citations

Phosphocreatine Represents a Thermodynamic and Functional Improvement Over Other Muscle Phosphagens

1989 • 148 citations

Homologous enzymes and biochemical evolution.

1969 • 145 citations

AN UNUSUAL ISOZYME OF LACTATE DEHYDROGENASE IN MATURE TESTES: LOCALIZATION, ONTOGENY, AND KINETIC PROPERTIES*

1964 • 142 citations

Changes in freeze-fractured mitochondrial membranes correlated to their energetic state

1983 • 132 citations

Bioenergetics: Dissecting the role of creatine kinase

1994 • 127 citations

Sperm creatine phosphokinase M-isoform ratios and fertilizing potential of men: a blinded study of 84 couples treated with in vitro fertilization

1992 • 125 citations

RATE OF FORMATION AND DISAPPEARANCE OF BODY CREATINE IN NORMAL ANIMALS

1941 • 118 citations

Creatine kinase: The reactive cysteine is required for synergism but is nonessential for catalysis

1993 • 117 citations

Activation of Sea Urchin Gametes

1986 • 108 citations

Adenylate Kinase-catalyzed Phosphoryl Transfer Couples ATP Utilization with Its Generation by Glycolysis in Intact Muscle

1995 • 108 citations

A sperm-supplied factor required for embryogenesis in C. elegans

1996 • 108 citations

Mitochondrial creatine kinase: a key enzyme of aerobic energy metabolism

1992 • 106 citations

Male Genital Organs

1995 • 106 citations

Local ATP regeneration is important for sarcoplasmic reticulum Ca2+ pump function

1994 • 105 citations

Functional coupling between sarcoplasmic‐reticulum‐bound creatine kinase and Ca²⁺‐ATPase

1993 • 103 citations

Creatine kinase-dependent energy transport in sea urchin spermatozoa. Flagellar wave attenuation and theoretical analysis of high energy phosphate diffusion

1987 • 102 citations

'Hot Spots' of Creatine Kinase Localization in Brain: Cerebellum, Hippocampus and Choroid Plexus

1996 • 101 citations

Dynamic compartmentation of adenine nucleotides in the mitochondrial intermembrane space of rat-heart mitochondria

1987 • 97 citations

Suppression of Creatine Kinase-catalyzed Phosphotransfer Results in Increased Phosphoryl Transfer by Adenylate Kinase in Intact Skeletal Muscle

1996 • 95 citations

Tissue-Specific and Developmentally Regulated Expression of the Genes Encoding Adenylate Kinase Isozymes1

1993 • 93 citations

Creatine kinase isoenzymes in spermatozoa

1986 • 93 citations

Spermatozoa: models for studying regulatory aspects of energy metabolism

1996 • 92 citations

Mitochondrial creatine kinase from cardiac muscle and brain are two distinct isoenzymes but both form octameric molecules.

1988 • 88 citations

Location and regulation of octameric mitochondrial creatine kinase in the contact sites

1991 • 85 citations

Creatine kinase immunocytochemistry of human sperm-hemizona complexes: selective binding of sperm with mature creatine kinase-staining pattern

1994 • 84 citations

THE ROLE OF EXTERNAL SODIUM IN SEA URCHIN FERTILIZATION11This work was supported by a grant from the National Science Foundation to Dr. D. Epel.

1978 • 81 citations

The importance of the outer mitochondrial compartment in regulation of energy metabolism

1994 • 78 citations

Spermatogenesis‐related change in the synthesis of the creatine kinase B‐type and M‐type isoforms in human spermatozoa

1990 • 75 citations

Enhancement of human sperm motility and velocity in vitro: effects of calcium and creatine phosphate

1986 • 74 citations

Adenylate Kinase Activity in Ejaculated Bovine Sperm Flagella

1989 • 74 citations

The phosphocreatine shuttle of sea urchin sperm: flagellar creatine kinase resulted from a gene triplication.

1990 • 73 citations

Amino acid sequence studies on lactate dehydrogenase C4 isozymes from mouse and rat testes.

1983 • 68 citations

Ultrastructure of spermatozoa from domesticated birds: comparative study of turkey, chicken and guinea fowl.

1987 • 68 citations

Energy transport and cell polarity: Relationship of phosphagen kinase activity to sperm function

1989 • 64 citations

Enzyme termini of a phosphocreatine shuttle. Purification and characterization of two creatine kinase isozymes from sea urchin sperm.

1987 • 63 citations

Specific enhancement of the cardiac myofibrillar ATPase by bound creatine kinase.

1992 • 62 citations

Phosphagen Kinases and Evolution in the Echinodermata

1967 • 60 citations

ULTRASTRUCTURAL STUDIES ON THE UTEROVAGINAL SPERM-HOST GLANDS OF THE DOMESTIC HEN, GALLUS DOMESTICUS

1973 • 58 citations

Phosphorylation of chicken brain‐type creatine kinase affects a physiologically important kinetic parameter and gives rise to protein microheterogeneity in vivo

1990 • 58 citations

Functional development of the creatine kinase system in perinatal rabbit heart.

1991 • 56 citations

Cell and muscle motility

1985 • 56 citations

THE ULTRASTRUCTURE OF THE EJACULATED FOWL SPERMATOZOON

1968 • 54 citations

Mice deficient in ubiquitous mitochondrial creatine kinase are viable and fertile

1995 • 53 citations

OBSERVATIONS ON THE FINE STRUCTURE OF SPERMATOZOA IN THE TESTIS AND EXCURRENT DUCTS OF THE MALE FOWL, GALLUS DOMESTICUS

1973 • 53 citations

The Role of Phosphate Esters in Male Fertility

1978 • 53 citations

Detection and relative quantitation of mRNA for creatine kinase isoenzymes in mRNA from myogenic cell cultures and embryonic chicken tissues.

1978 • 53 citations

Creatine Kinase Isoenzymes in Chicken Cerebellum: Specific Localization of Brain‐type Creatine Kinase in Bergmann Glial Cells and Muscle‐type Creatine Kinase in Purkinje Neurons

1994 • 52 citations

31P-NMR analysis of sea urchin sperm activation

1983 • 48 citations

The Lactate/Pyruvate Shuttle in Spermatozoa: Operation in Vitro

1994 • 48 citations

Differential expression and localization of brain-type and mitochondrial creatine kinase isoenzymes during development of the chicken retina: Mi-CK as a marker for differentiation of photoreceptor cells

1991 • 47 citations

Regulation of creatine phosphokinase B activity by protein kinase C

1990 • 47 citations

Metabolism of lipid and carbohydrate in sea urchin spermatozoa

1983 • 46 citations

Identification of two distinctly localized mitochondrial creatine kinase isoenzymes in spermatozoa

1996 • 46 citations

Phosphocreatine, an intracellular high-energy compound, is found in the extracellular fluid of the seminal vesicles in mice and rats.

1988 • 45 citations

31P-NMR-measured creatine kinase reaction flux in muscle: a caveat!

1996 • 43 citations

Purification and identification of creatine phosphokinase B as a substrate of protein kinase C in mouse skin in vivo

1990 • 42 citations

Re-evaluation of the structure and physiological function of guanidino kinases in fruitfly (Drosophila), sea urchin (Psammechinus miliaris) and man

1995 • 41 citations

Activation of sea-urchin sperm motility is accompanied by an increase in the creatine kinase exchange flux

1997 • 38 citations

Horseshoe crab sperm contain a unique isoform of arginine kinase that is present in midpiece and flagellum

1993 • 37 citations

Glycolytic enzymes in mammalian spermatozoa. Activities and stabilities of hexokinase and phosphofructokinase in various fractions from sperm homogenates

1971 • 36 citations

The Head, Neck and Midpiece of Cock Spermatozoa Examined with the Transmission Electron Microscope

1975 • 36 citations

Adenosine Triphosphate (ATP) Concentrations and ATP/Adenosine Diphosphate Ratios in Human Sperm of Normospermic, Oligospermic, and Asthenospermic Specimens and in their Swim‐up Fractions: Lack of Correlation Between ATP Parameters and Sperm Creatine Kinase Concentrations

1992 • 34 citations

A modified assay procedure for revealing the M form of creatine kinase in cultured muscle cells

1978 • 33 citations

Myristoylation of flagellar creatine kinase in the sperm phosphocreatine shuttle is linked to its membrane association properties.

1992 • 33 citations

Phosphorus-31 nuclear magnetic resonance studies of spermatozoa from the boar, ram, goat and bull

1987 • 27 citations

Biochemical markers of early and late spermatogenesis: Relationship between the lactate dehydrogenase-X and creatine kinase-M isoform concentrations in human spermatozoa

1996 • 27 citations

The Pasteur effect in facultative anaerobic metazoa

1996 • 27 citations

Sea urchin sperm creatine kinase: The flagellar isozyme is a microtubule-associated protein

1988 • 26 citations

Creatine kinase and ATPase in human seminal fluid and prostatic fluid

1983 • 26 citations

A novel creatine kinase cDNA whose transcript shows enhanced testicular expression

1990 • 26 citations

Guanidine Compounds and Phosphagens

1969 • 26 citations

Membrane association of flagellar creatine kinase in the sperm phosphocreatine shuttle.

1991 • 25 citations

Localization and catalytic properties of lactate dehydrogenase in different sperm models

1975 • 23 citations

The existential decision of a sperm

1987 • 22 citations

Creatine kinase in trout male germ cells: Purification, gene expression, and localization in the testis

1996 • 21 citations

Creatine kinase in seminal plasma of infertile men: Activity and isoenzymes

1981 • 20 citations

Regulation of flagellar motility by temperature-dependent phosphorylation of a 43 kDa axonemal protein in fowl spermatozoa

1992 • 20 citations

Myristoylated and Nonmyristoylated Pools of Sea Urchin Sperm Flagellar Creatine Kinase Exist Side-by-Side: Myristoylation Is Necessary for Efficient Lipid Association

1997 • 19 citations

Studies on echinoderm phosphagens

1968 • 17 citations

Studies on echinoderm phosphagens III. Changes in the content of creatine phosphate after stimulation of sperm motility

1967 • 15 citations

High-energy phosphate compounds in spermatozoa of the sea urchins Arbacia lixula and Paracentrotus lividus

1994 • 14 citations

Purification and Characterization of Sperm Creatine Kinase and Guanylate Cyclase of the Sea Urchin Hemicentrotus pulcherrimus

1992 • 14 citations

CHANGES IN ACTIVITIES OF CREATINE KINASE, ARGININE KINASE AND THEIR MULTIENZYME FORMS DURING EMBRYONIC AND LARVAL DEVELOPMENT OF SEA URCHINS

1978 • 14 citations

Distribution and behaviour of some glycolytic enzymes in spermatozoa and cytoplasmic droplets from mammalian semen

1969 • 12 citations

Some Enzyme Activities of Chicken Spermatozoa

1970 • 10 citations

EXAMINATION OF BULL SEMEN AND OF THE BULL AND RABBIT TESTIS FOR THE PRESENCE OF CREATINE PHOSPHATE AND ARGININE PHOSPHATE

1971 • 9 citations

Comparison of the two different phosphagen systems in the lugworm Arenicola marina

1995 • 8 citations

Glycogenolysis during Recovery from Muscular Work. The Time Course of Phosphorylase Activity is Dependent on P_iConcentration in the Abdominal Muscle of the ShrimpCrangon crangon

1989 • 7 citations

Covalent Modification of Creatine Kinase by ATP: Evidence for Autophosphorylation

1991 • 7 citations