Cell adhesion in vascular biology. New insights into integrin-ligand interaction.

Allosteric proteins and cellular control systems

1963 • 2,187 citations

The 2.0 Å crystal structure of a heterotrimeric G protein

1996 • 1,118 citations

Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation.

1985 • 968 citations

Crystal structure of the A domain from the a subunit of integrin CR3 (CD11 b/CD18)

1995 • 893 citations

2.0 Å Crystal Structure of a Four-Domain Segment of Human Fibronectin Encompassing the RGD Loop and Synergy Region

1996 • 621 citations

Breaking the Integrin Hinge

1996 • 567 citations

Structure of a Fibronectin Type III Domain from Tenascin Phased by MAD Analysis of the Selenomethionyl Protein

1992 • 500 citations

The three-dimensional structure of the tenth type III module of fibronectin: An insight into RGD-mediated interactions

1992 • 472 citations

A β ₃ Integrin Mutation Abolishes Ligand Binding and Alters Divalent Cation-Dependent Conformation

1990 • 418 citations

Folding of the N-terminal, ligand-binding region of integrin α-subunits into a β-propeller domain

1997 • 414 citations

Two conformations of the integrin A-domain (I-domain): a pathway for activation?

1995 • 400 citations

A novel divalent cation-binding site in the a domain of the ?2 integrin CR3 (CD11b/CD18) is essential for ligand binding

1993 • 383 citations

Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function.

1991 • 367 citations

Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin.

1995 • 308 citations

cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95.

1987 • 277 citations

Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex

1991 • 270 citations

Ligand and cation binding are dual functions of a discrete segment of the integrin β3 subunit: Cation displacement is involved in ligand binding

1994 • 220 citations

Identification of a regulatory region of integrin beta 1 subunit using activating and inhibiting antibodies

1993 • 206 citations

Integrin-mediated cell adhesion: the extracellular face.

1994 • 204 citations

The Conserved Membrane-proximal Region of an Integrin Cytoplasmic Domain Specifies Ligand Binding Affinity

1995 • 202 citations

Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 Å resolution

1995 • 187 citations

Ligand Binding to Integrin αIIbβ3 Is Dependent on a MIDAS-like Domain in the β3 Subunit

1996 • 168 citations

Modulation of cell adhesion by changes in alpha L beta 2 (LFA-1, CD11a/CD18) cytoplasmic domain/cytoskeleton interaction.

1995 • 167 citations

A Binding Interface on the I Domain of Lymphocyte Function-associated Antigen-1 (LFA-1) Required for Specific Interaction with Intercellular Adhesion Molecule 1 (ICAM-1)

1995 • 164 citations

Mutation of a ligand binding domain of beta 3 integrin. Integral role of oxygenated residues in alpha IIb beta 3 (GPIIb-IIIa) receptor function.

1994 • 147 citations

The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin

1996 • 134 citations

Identifying the Putative Metal Ion-dependent Adhesion Site in the β2 (CD18) Subunit Required for αLβ2 and αMβ2 Ligand Interactions

1996 • 103 citations

Critical Threonine and Aspartic Acid Residues within the I Domains of β2 Integrins for Interactions with Intercellular Adhesion Molecule 1 (ICAM-1) and C3bi

1995 • 95 citations

Critical Residues for Ligand Binding in an I Domain-like Structure of the Integrin β1 Subunit

1996 • 85 citations

Dynamic regulation of integrins

1995 • 67 citations

Conformational modulation of purified glycoprotein (GP) IIb-IIIa allows proteolytic generation of active fragments from either active or inactive GPIIb-IIIa.

1992 • 66 citations

A highly conserved sequence of the Arg-Gly-Asp-binding domain of the integrin beta 3 subunit is sensitive to stimulation

1991 • 60 citations

Solvent-accessible Residues on the Metal Ion-dependent Adhesion Site Face of Integrin CR3 Mediate Its Binding to the Neutrophil Inhibitory Factor

1996 • 57 citations

A Discrete Site Modulates Activation of I Domains

1996 • 46 citations