Re-evaluation of the molecular pharmacology of mitomycin C

Mitomycins and Porfiromycin: Chemical Mechanism of Activation and Cross-linking of DNA

1964 • 565 citations

Isolation and Structure of a Covalent Cross-Link Adduct Between Mitomycin C and DNA

1987 • 454 citations

Bioactivation as a Model for Drug Design Bioreductive Alkylation

1977 • 432 citations

Mitomycin C: Current status and new developments

1979 • 296 citations

Metabolism and reactions of quinoid anticancer agents

1987 • 273 citations

Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells.

1990 • 222 citations

Preferential activation of mitomycin C to cytotoxic metabolites by hypoxic tumor cells.

1980 • 220 citations

Reductive activation of mitomycin C and mitomycin C metabolites catalyzed by NADPH-cytochrome P-450 reductase and xanthine oxidase.

1984 • 214 citations

DT-diaphorase in activation and detoxification of quinones

1993 • 188 citations

Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1.

1984 • 178 citations

Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: Relationship to the response of lung tumor xenografts to mitomycin C

1993 • 161 citations

Bioreductive activation of mitomycin C by DT-diaphorase

1992 • 158 citations

Reaction of DNA with chemically or enzymatically activated mitomycin C: isolation and structure of the major covalent adduct.

1986 • 144 citations

Reductive metabolism and alkylating activity of mitomycin C induced by rat liver microsomes

1981 • 132 citations

Mechanism of monofunctional and bifunctional alkylation of DNA by mitomycin C

1988 • 118 citations

Reductive activation of mitomycin C by NADH:cytochrome b5 reductase.

1993 • 116 citations

Isolation and structure of an intrastrand cross-link adduct of mitomycin C and DNA

1992 • 105 citations

Metabolism of bioreductive antitumor compounds by purified rat and human DT-diaphorases.

1994 • 99 citations

Decreased NADPH:cytochrome P-450 reductase activity and impaired drug activation in a mammalian cell line resistant to mitomycin C under aerobic but not hypoxic conditions.

1990 • 85 citations

Interactions of mitomycin C with mammalian DNA detected by alkaline elution.

1985 • 84 citations

Reductive activation of mitomycin C

1988 • 78 citations

Sequence preferences of DNA interstrand cross-linking agents: dG-to-dG cross-linking at 5'-CG by structurally simplified analogs of mitomycin C

1990 • 76 citations

Recognition of specific DNA sequences by mitomycin C for alkylation

1992 • 75 citations

Studies on the bonding specificity for mitomycin C-DNA monoalkylation processes

1991 • 74 citations

Mechanisms of hypoxic and aerobic cytotoxicity of mitomycin C in Chinese hamster V79 cells.

1991 • 70 citations

Keynote address: Bioreductive mechanisms

1992 • 69 citations

Unusually marked hypoxic sensitization to indoloquinone E09 and mitomycin C in a human colon‐tumour cell line that lacks DT‐diaphorase activity

1994 • 66 citations

Solution Structure of the Monoalkylated Mitomycin C–DNA Complex

1995 • 62 citations

The diffusion of a tumour-specific monoclonal antibody in lymphoma infiltrated spleen

1987 • 60 citations

DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9

1994 • 57 citations

DNA alkylation by enzyme-activated mitomycin C.

1986 • 57 citations

Chinese hamster ovary cell lines resistant to mitomycin C under aerobic but not hypoxic conditions are deficient in DT-diaphorase.

1991 • 54 citations

Autocatalytic quinone methide formation from mitomycin c

1986 • 53 citations

Cellular pharmacology of quinone bioreductive alkylating agents

1993 • 51 citations

New findings in the pharmacokinetic, metabolic, and drug-resistance aspects of mitomycin C.

1988 • 50 citations

Mitomycin C (NSC-26980)--an evaluation of the Japanese reports.

1960 • 48 citations

Studies on the mechanism of resistance to mitomycin C and porfiromycin in a human cell strain derived from a cancer-prone individual

1991 • 43 citations

Cytotoxicity of mitomycin C and adriamycin in freshly isolated rat hepatocytes: the role of cytochrome P450.

1994 • 40 citations

Adducts of mitomycin C and DNA in EMT6 mouse mammary tumor cells: effects of hypoxia and dicumarol on adduct patterns.

1993 • 39 citations

The enzymology of doxorubicin quinone reduction in tumour tissue

1992 • 38 citations

Pharmacokinetics of mitomycin C in rabbit and human

1982 • 37 citations

Relevance of DT‐diaphorase activity to mitomycin C (MMC) efficacy on human cancer cells: Differences in in vitro and in vivo systems

1993 • 36 citations

DT-diaphorase activity and mitomycin C sensitivity in non-transformed cell strains derived from members of a cancer-prone family

1991 • 36 citations

pH-dependent inactivation of DT-diaphorase by mitomycin C and porfiromycin.

1993 • 33 citations

Enhancement of xanthine dehydrogenase mediated mitomycin C metabolism by dicumarol.

1992 • 32 citations

The role of NAD(P)H: quinone oxidoreductase in mitomycin C- and porfiromycin-resistant HCT 116 human colon-cancer cells

1992 • 31 citations

Are reduced quinones necessarily involved in the antitumour activity of quinone drugs?

1987 • 30 citations

Increased activity and expression of NAD(P)H:quinone acceptor oxidoreductase in confluent cell cultures and within multicellular spheroids.

1994 • 29 citations

Studies on the reactivity of reductively activated mitomycin C

1993 • 29 citations

Kinetics and mechanism of mitomycin C bioactivation by xanthine dehydrogenase under aerobic and hypoxic conditions.

1993 • 26 citations

Sequence-selective alkylation and cross-linking induced by mitomycin C upon activation by DT-diaphorase

1993 • 26 citations

Binding of 2,7-Diaminomitosene to DNA: Model for the Recognition of DNA by activated mitomycin C

1995 • 25 citations

Determination of mitomycin C, 2,7-diaminomitosene, 1,2-cis- and 1,2-trans-1-hydroxy-2,7-diaminomitosene in tumour tissue by high-performance liquid chromatography

1993 • 21 citations

Encapsulation of mitomycin C in albumin microspheres markedly alters pharmacokinetics, drug quinone reduction in tumour tissue and antitumour activity

1994 • 20 citations

Conversion of mitomycin C to 2,7-diaminomitosene and 10-decarbamoyl 2,7-diaminomitosene in tumour tissue in vivo

1995 • 17 citations

Pharmacokinetics and toxicity of mitomycin C in rodents, given alone, in combination, or after induction of microsomal drug matabolism

1988 • 13 citations

Chemical modification of DNA with muta-carcinogens. III. Reductive alkylation of DNA with mitomycin C.

1985 • 10 citations

Reductively activated mitomycin C: an efficient trapping reagent for electrophiles

1992 • 10 citations

Mitomycin C toxicity and pharmacokinetics in mice given sulfur nucleophiles.

1988 • 3 citations

Distortion After Monofunctional Alkylation by Mitomycin C of a Dodecamer Containing its Major Binding Site

1995 • 3 citations

ChemInform Abstract: Studies on the Reactivity of Reductively Activated Mitomycin C (I).

1994 • 2 citations