Encapsulation of mitomycin C in albumin microspheres markedly alters pharmacokinetics, drug quinone reduction in tumour tissue and antitumour activity

Mitomycins and Porfiromycin: Chemical Mechanism of Activation and Cross-linking of DNA

1964 • 565 citations

Bioactivation as a Model for Drug Design Bioreductive Alkylation

1977 • 432 citations

Mitomycin C: Current status and new developments

1979 • 296 citations

Metabolism and reactions of quinoid anticancer agents

1987 • 273 citations

Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells.

1990 • 222 citations

Preferential activation of mitomycin C to cytotoxic metabolites by hypoxic tumor cells.

1980 • 220 citations

Reductive activation of mitomycin C and mitomycin C metabolites catalyzed by NADPH-cytochrome P-450 reductase and xanthine oxidase.

1984 • 214 citations

DT-diaphorase in activation and detoxification of quinones

1993 • 188 citations

Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1.

1984 • 178 citations

Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: Relationship to the response of lung tumor xenografts to mitomycin C

1993 • 161 citations

Bioreductive activation of mitomycin C by DT-diaphorase

1992 • 158 citations

Generation of free radicals of quinone group-containing anti-cancer chemicals in NADPH-microsome system as evidenced by initiation of sulfite oxidation.

1975 • 154 citations

Reaction of DNA with chemically or enzymatically activated mitomycin C: isolation and structure of the major covalent adduct.

1986 • 144 citations

Reductive metabolism and alkylating activity of mitomycin C induced by rat liver microsomes

1981 • 132 citations

Reductive activation of mitomycin C by NADH:cytochrome b5 reductase.

1993 • 116 citations

Adriamycin‐loaded albumin microspheres: Preparation, in vivo distribution and release in the rat

1985 • 106 citations

Pharmacokinetics of mitomycin C in humans.

1983 • 92 citations

Sustained-release properties of microencapsulated mitomycin C with ethylcellulose infused into the renal artery of the dog

1980 • 86 citations

Decreased NADPH:cytochrome P-450 reductase activity and impaired drug activation in a mammalian cell line resistant to mitomycin C under aerobic but not hypoxic conditions.

1990 • 85 citations

Reductive activation of mitomycin C

1988 • 78 citations

pH dependence of mitomycin C-induced cross-linking activity in EMT6 tumor cells.

1985 • 78 citations

Mechanisms of hypoxic and aerobic cytotoxicity of mitomycin C in Chinese hamster V79 cells.

1991 • 70 citations

Keynote address: Bioreductive mechanisms

1992 • 69 citations

Metabolic activation of mitomycin C by liver microsomes and nuclei

1982 • 67 citations

Bioactivation of Mitomycin C by Xanthine Dehydrogenase From EMT6 Mouse Mammary Carcinoma Tumors

1992 • 67 citations

Preparation andin vitroevaluation of polylactic acid-mitomycin C microcapsules

1986 • 66 citations

The diffusion of a tumour-specific monoclonal antibody in lymphoma infiltrated spleen

1987 • 60 citations

DT-diaphorase activity correlates with sensitivity to the indoloquinone EO9 in mouse and human colon carcinomas

1992 • 54 citations

Chinese hamster ovary cell lines resistant to mitomycin C under aerobic but not hypoxic conditions are deficient in DT-diaphorase.

1991 • 54 citations

Phase I study of hepatic arterial degradable starch microspheres and mitomycin.

1985 • 53 citations

Mitomycin C is not metabolized by but is an inhibitor of human kidney NAD(P)H:(quinone-acceptor)oxidoreductase

1988 • 49 citations

Microspheres and Regional Cancer Therapy

2020 • 48 citations

Microencapsulation of drugs

1993 • 45 citations

The consequences of doxorubicin quinone reduction in vivo in tumour tissue

1992 • 45 citations

Studies on the mechanism of resistance to mitomycin C and porfiromycin in a human cell strain derived from a cancer-prone individual

1991 • 43 citations

Role of NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase) in activation of mitomycin C under hypoxia.

1992 • 41 citations

Bioreductive drugs as post-irradiation sensitizers: Comparison of dual function agents with SR 4233 and the mitomycin C analogue EO9

1992 • 40 citations

The enzymology of doxorubicin quinone reduction in tumour tissue

1992 • 38 citations

Increased anti-tumor effect of adriamycin-loaded albumin microspheres is associated with anaerobic bioreduction of drug in tumor tissue

1987 • 36 citations

Relevance of DT‐diaphorase activity to mitomycin C (MMC) efficacy on human cancer cells: Differences in in vitro and in vivo systems

1993 • 36 citations

DT-diaphorase activity and mitomycin C sensitivity in non-transformed cell strains derived from members of a cancer-prone family

1991 • 36 citations

Mitomycin antitumour agents: A review of their physico-chemical and analytical properties and stability

1986 • 35 citations

Enhancement of xanthine dehydrogenase mediated mitomycin C metabolism by dicumarol.

1992 • 32 citations

The role of NAD(P)H: quinone oxidoreductase in mitomycin C- and porfiromycin-resistant HCT 116 human colon-cancer cells

1992 • 31 citations

Are reduced quinones necessarily involved in the antitumour activity of quinone drugs?

1987 • 30 citations

Continued in vitro and in vivo release of an antitumor drug from albumin microspheres

1983 • 29 citations

Sequence-selective alkylation and cross-linking induced by mitomycin C upon activation by DT-diaphorase

1993 • 26 citations

Modulation of mitomycin C resistance by glutathione transferase inhibitor ethacrynic acid

1992 • 24 citations

One-electron reduction of mitomycin c by rat liver: Role of cytochrome P-450 and NADPH-cytochrome P-450 reductase

1990 • 24 citations

The effects of three bioreductive drugs (mitomycin C, RSU-1069 and SR4233) on cell lines selected for their sensitivity to mitomycin C or ionising radiation

1990 • 21 citations

Determination of mitomycin C, 2,7-diaminomitosene, 1,2-cis- and 1,2-trans-1-hydroxy-2,7-diaminomitosene in tumour tissue by high-performance liquid chromatography

1993 • 21 citations

Adriamycin and DT-diaphorase

1986 • 20 citations

Properties of mitomycin C-albumin conjugates in vitro and in vivo

1991 • 17 citations

Relationship between reductive drug metabolism in tumour tissue of anthracyclines in microspherical form and anti-tumour activity

1990 • 17 citations

Relationship between clinical parameters and pharmacokinetics of mitomycin C

1987 • 17 citations

Plasma disposition and in vivo and in vitro antiumor activities of mitomycin C-dextran conjugate in relation to the mode of action.

1985 • 17 citations

Pharmacokinetics of mitomycin-C in plasma and tumor tissue of cervical cancer patients and in selected tissues of female rats

1986 • 16 citations

Mitomycin C pharmacokinetics in patients with recurrent or metastatic colorectal carcinoma

1987 • 15 citations

Targeting of mitomycin C to the liver by the use of asialofetuin as a carrier.

1991 • 14 citations

Preparation and evaluation of biodegradable albumin microspheres containing mitomycin C

1990 • 14 citations

Preparation and properties of a mitomycin C-albumin conjugate.

1990 • 13 citations

Studies on the mechanism of the cytotoxic action of the mitomycin antibiotics in hypoxic and oxygenated EMT6 cells

1993 • 12 citations

Chromatographic studies of mitomycin C degradation in albumin microspheres

1988 • 11 citations

Targeting cancer chemotherapy using a monoclonal antibody (NCC‐LU‐243) conjugated with mitomycin C

1992 • 9 citations

Incorporation and Release of Chemically Intact Mitomycin C from Albumin Microspheres: a High Performance Liquid Chromatography Evaluation

1993 • 8 citations

Correlation between tumour drug disposition and the antitumour activity of doxorubicin-loaded microspheres: implications for the drugs' in vivo mechanism of action

1993 • 7 citations

Degradable starch microspheres in cytostatic treatment of a liver carcinoma; experimental studies in rats with 5-fluorouracil, tauromustine, carmustine, doxorubicin and RSU-1069.

1993 • 6 citations

Pharmaceutical Aspects of Cancer Chemotherapy

1993 • 4 citations

A bioassay to measure cytotoxicity of plasma from patients treated with mitomycin C.

1985 • 4 citations