Chinese hamster ovary cell lines resistant to mitomycin C under aerobic but not hypoxic conditions are deficient in DT-diaphorase.

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Hepatic Triphosphopyridine Nucleotide-Cytochrome c Reductase: Isolation, Characterization, and Kinetic Studies

1962 • 1,431 citations

The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells.

1982 • 893 citations

Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity.

1980 • 757 citations

Mitomycin C: a review

1976 • 441 citations

The hypoxic tumor cell: A target for selective cancer chemotherapy

1980 • 291 citations

Metabolism and reactions of quinoid anticancer agents

1987 • 273 citations

Preferential activation of mitomycin C to cytotoxic metabolites by hypoxic tumor cells.

1980 • 220 citations

Reductive activation of mitomycin C and mitomycin C metabolites catalyzed by NADPH-cytochrome P-450 reductase and xanthine oxidase.

1984 • 214 citations

Hypersensitivity to mutation and sister-chromatid-exchange induction in CHO cell mutants defective in incising DNA containing UV lesions

1982 • 129 citations

Free radicals in anticancer drug pharmacology

1989 • 106 citations

Enhancement of mitomycin C cytotoxicity to hypoxic tumor cells by dicoumarol in vivo and in vitro.

1985 • 71 citations

Deficient activation by a human cell strain leads to mitomycin resistance under aerobic but not hypoxic conditions

1989 • 64 citations

Cytotoxicity and DNA lesions produced by mitomycin C and porfiromycin in hypoxic and aerobic EMT6 and Chinese hamster ovary cells.

1986 • 60 citations

DNA alkylation by enzyme-activated mitomycin C.

1986 • 57 citations

Increased sensitivity of quinone resistant cells to mitomycin C

1989 • 57 citations

Modification of the cytotoxic activity of mitomycin C by oxygen and ascorbic acid in Chinese hamster ovary cells and a repair-deficient mutant.

1986 • 55 citations

Mitomycin C is not metabolized by but is an inhibitor of human kidney NAD(P)H:(quinone-acceptor)oxidoreductase

1988 • 49 citations

Quinoneimines as substrates for quinone reductase (NAD(P)H : (Quinone-acceptor)oxidoreductase) and the effect of dicumarol on their cytotoxicity

1987 • 48 citations

Isolation of Chinese hamster ovary cell mutants deficient in excision repair and mitomycin C bioactivation.

1989 • 41 citations

Modification of the metabolism and cytotoxicity of bioreductive alkylating agents by dicoumarol in aerobic and hypoxic murine tumor cells.

1989 • 34 citations

DNA cross-linking by intermediates in the mitomycin activation cascade

1989 • 28 citations

Modulation of the cytotoxicity of mitomycin C to EMT6 mouse mammary tumor cells by dicoumarol in vitro.

1988 • 24 citations

The effects of adriamycin on intracellular calcium concentrations of L1210 murine leukemia cell

1987 • 13 citations

Relationship Between the Antioxidant Enzyme DT-Diaphorase and Tumor Response to Mitomycin C Treatment

1988 • 11 citations

Complementation of the DNA-repair defect in a CHO mutant by human DNA that lacks highly abundant repetitive sequences

1988 • 10 citations