Mechanisms of hypoxic and aerobic cytotoxicity of mitomycin C in Chinese hamster V79 cells.

Spin Trapping: ESR parameters of spin adducts 1474 1528V

1987 • 1,660 citations

The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells.

1982 • 893 citations

Mitomycins and Porfiromycin: Chemical Mechanism of Activation and Cross-linking of DNA

1964 • 565 citations

A MOLECULAR MECHANISM OF MITOMYCIN ACTION: LINKING OF COMPLEMENTARY DNA STRANDS

1963 • 564 citations

Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells.

1981 • 552 citations

Isolation and Structure of a Covalent Cross-Link Adduct Between Mitomycin C and DNA

1987 • 454 citations

Biologically active metal-independent superoxide dismutase mimics

1990 • 427 citations

Spin-trapping and direct electron spin resonance investigations of the redox metabolism of quinone anticancer drugs

1980 • 317 citations

The hypoxic tumor cell: A target for selective cancer chemotherapy

1980 • 291 citations

Anthracycline antibiotic-stimulated superoxide, hydrogen peroxide, and hydroxyl radical production by NADH dehydrogenase.

1983 • 282 citations

Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, Tempol

1991 • 229 citations

A novel metal-free low molecular weight superoxide dismutase mimic.

1988 • 228 citations

Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells.

1990 • 222 citations

Cardiac reperfusion damage prevented by a nitroxide free radical.

1991 • 176 citations

Inhibition of Lipid Peroxidation by Spin Labels

1989 • 173 citations

Nitroxide stable radicals protect beating cardiomyocytes against oxidative damage.

1991 • 146 citations

Superoxide reaction with nitroxide spin-adducts

1989 • 135 citations

Nitroxides block DNA scission and protect cells from oxidative damage

1991 • 94 citations

Hypoxia-mediated nitro-heterocyclic drugs in the radio- and chemotherapy of cancer

1986 • 93 citations

An electron spin resonance study of the reduction of peroxides by anthracycline semiquinones

1984 • 90 citations

Reactions of the semiquinone free radicals of anti‐tumour agents with oxygen and iron complexes

1985 • 86 citations

Interactions of mitomycin C with mammalian DNA detected by alkaline elution.

1985 • 84 citations

pH dependence of mitomycin C-induced cross-linking activity in EMT6 tumor cells.

1985 • 78 citations

The Effects of Cellular Glutathione Elevation on the Oxygen Enhancement Ratio

1985 • 69 citations

Deficient activation by a human cell strain leads to mitomycin resistance under aerobic but not hypoxic conditions

1989 • 64 citations

DNA alkylation by enzyme-activated mitomycin C.

1986 • 57 citations

Increased sensitivity of quinone resistant cells to mitomycin C

1989 • 57 citations

Chinese hamster ovary cell lines resistant to mitomycin C under aerobic but not hypoxic conditions are deficient in DT-diaphorase.

1991 • 54 citations

Mitomycin C is not metabolized by but is an inhibitor of human kidney NAD(P)H:(quinone-acceptor)oxidoreductase

1988 • 49 citations

Quinoneimines as substrates for quinone reductase (NAD(P)H : (Quinone-acceptor)oxidoreductase) and the effect of dicumarol on their cytotoxicity

1987 • 48 citations

Baculovirus-mediated expression and functional characterization of human NADPH-P450 oxidoreductase

1992 • 38 citations

DT-diaphorase activity and mitomycin C sensitivity in non-transformed cell strains derived from members of a cancer-prone family

1991 • 36 citations

DNA cross-linking by intermediates in the mitomycin activation cascade

1989 • 28 citations

Chemical Modification of Radiation and Chemotherapy

1988 • 22 citations