Sequence-selective alkylation and cross-linking induced by mitomycin C upon activation by DT-diaphorase

A MOLECULAR MECHANISM OF MITOMYCIN ACTION: LINKING OF COMPLEMENTARY DNA STRANDS

1963 • 564 citations

[56] DT diaphorase

1967 • 521 citations

Isolation and Structure of a Covalent Cross-Link Adduct Between Mitomycin C and DNA

1987 • 454 citations

Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells.

1990 • 222 citations

Bioreductive activation of mitomycin C by DT-diaphorase

1992 • 158 citations

Mechanism of monofunctional and bifunctional alkylation of DNA by mitomycin C

1988 • 118 citations

Isolation and structure of an intrastrand cross-link adduct of mitomycin C and DNA

1992 • 105 citations

DNA sequence specificity of mitomycin cross-linking

1989 • 80 citations

NMR and computational characterization of mitomycin cross-linked to adjacent deoxyguanosines in the minor groove of the d(T-A-C-G-T-A).cntdot.d(T-A-C-G-T-A) duplex

1990 • 79 citations

DNA-directed alkylating ligands as potential antitumor agents: sequence specificity of alkylation by intercalating aniline mustards

1990 • 76 citations

Recognition of specific DNA sequences by mitomycin C for alkylation

1992 • 75 citations

Studies on the bonding specificity for mitomycin C-DNA monoalkylation processes

1991 • 74 citations

Sequence preferences of DNA interstrand crosslinking agents: quantitation of interstrand crosslink locations in DNA duplex fragments containing multiple crosslinkable sites

1991 • 58 citations

The N2-guanine adduct but not the C8-guanine of N6-adenine adducts formed by 4-nitroquinoline 1-oxide blocks the 3'-5' exonuclease action of T4 DNA polymerase

1990 • 53 citations

Autocatalytic quinone methide formation from mitomycin c

1986 • 53 citations

Duplex oligodeoxyribonucleotides crosslinked by mitomycin C at a single site: synthesis, properties, and crosslink

1990 • 48 citations

Purification by cibacron blue F3GA dye affinity chromatography and comparison of NAD(P)H:quinone reductase (E.C.1.6.99.2) from rat liver cytosol and microsomes

1989 • 39 citations

The reaction of anthramycin with DNA. Proton and carbon nuclear magnetic resonance studies on the structure of the anthramycin-DNA adduct.

1984 • 38 citations

Alkylation of DNA by C-10 of 2,7-diaminomitosene

1990 • 23 citations

The reaction of acetyl-4-hydroxyaminoquinoline 1-oxide with DNA: quantitation of single-strand break formation and hyper-reactivity of DNA termini

1991 • 6 citations