Reductive metabolism and alkylating activity of mitomycin C induced by rat liver microsomes

A general mechanism for microsomal activation of quinone anticancer agents to free radicals.

1978 • 645 citations

Mitomycins and Porfiromycin: Chemical Mechanism of Activation and Cross-linking of DNA

1964 • 565 citations

A MOLECULAR MECHANISM OF MITOMYCIN ACTION: LINKING OF COMPLEMENTARY DNA STRANDS

1963 • 564 citations

Bioactivation as a Model for Drug Design Bioreductive Alkylation

1977 • 432 citations

The hypoxic tumor cell: A target for selective cancer chemotherapy

1980 • 291 citations

Preferential activation of mitomycin C to cytotoxic metabolites by hypoxic tumor cells.

1980 • 220 citations

Studies related to antitumor antibiotics. Part V. Reactions of mitomycin C with DNA examined by ethidium fluorescence assay

1976 • 167 citations

The Structures of Mitomycins A, B, and C and Porfiromycin--Part II

1962 • 159 citations

Mitomycin C: Chemical and Biological Studies on Alkylation

1963 • 132 citations

Alkylation of Nucleic Acids by Mitomycin C and Porfiromycin^*

1965 • 94 citations

H2O2 generation during the redox cycle of mitomycin C and DNA-bound mitomycin C

1976 • 78 citations

Potential Bioreductive Alkylating Agents

1976 • 78 citations

Chemistry and Structure of Mitomycin C¹

1965 • 76 citations

Alkylation reactions of mitomycin C at acid pH

1979 • 67 citations

Mitomycin derivatives. 2. Derivatives of decarbamoylmitosane and decarbamoylmitosene

1971 • 54 citations

Aziridinomitosenes: A New Class of Antibiotics Related to the Mitomycins

1964 • 52 citations

Altered DNA isolated from cells treated with mitomycin C

1963 • 49 citations

Formation of 1-ethylxanthyl-2,7-diaminomitosene and 1,10-diethylxanthyl-2,7-diaminodecarbamoylmitosene in aqueous solution upon reduction-reoxidation of mitomycin C in the presence of potassium ethylxanthate

1979 • 34 citations

Structure and stereochemistry of some 1,2-disubstituted mitosenes from solvolysis of mitomycin C and Mitomycin A

1975 • 33 citations

Studies on the mode of action of the mitomycin antibiotics. Reversible conversion of mitomycin C into sodium 7-aminomitosane-9a-sulfonate

1976 • 31 citations

The Mitomycin Antibiotics. Synthetic Studies. XXII. Antibacterial Structure-Activity Relationships in the Indoloquinone Series

1968 • 25 citations

Alkylation of 5'-guanylic acid by reductively activated mitomycin C.

1980 • 14 citations

Inhibitory Effects of Mitomycin-Related Compounds Lacking the C ¹ -C ² Aziridine Ring

1972 • 13 citations