DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9

Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy

1988 • 811 citations

Effects of the pH dependence of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide-formazan absorption on chemosensitivity determined by a novel tetrazolium-based assay.

1989 • 580 citations

Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver.

1988 • 408 citations

One-electron-transfer reactions in biochemical systems V. Difference in the mechanism of quinone reduction by the NADH dehydrogenase and the NAD(P)H dehydrogenase (DT-diaphorase)

1970 • 335 citations

DT-diaphorase and cancer chemotherapy

1992 • 284 citations

Hypoxia in Tumors: A Paradigm for the Approach to Biochemical and Physiologic Heterogeneity

1988 • 246 citations

Reductive activation of mitomycin C and mitomycin C metabolites catalyzed by NADPH-cytochrome P-450 reductase and xanthine oxidase.

1984 • 214 citations

Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: Relationship to the response of lung tumor xenografts to mitomycin C

1993 • 161 citations

The experimental development of bioreductive drugs and their role in cancer therapy

1993 • 137 citations

Metabolism of diaziquone by NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase): role in diaziquone-induced DNA damage and cytotoxicity in human colon carcinoma cells.

1990 • 128 citations

The Role of NAD(P)H: Quinone Reductase (EC 1.6.99.2, DT-Diaphorase) in the Reductive Bioactivation of the Novel Indoloquinone Antitumor Agent E09

1991 • 122 citations

Generation of hydroxyl radical by anticancer quinone drugs, carbazilquinone, mitomycin C, aclacinomycin A and adriamycin, in the presence of NADPH-cytochrome P-450 reductase

1982 • 113 citations

EO9: A novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bone marrow toxicity in preclinical models

1993 • 106 citations

The differential hypoxic cytotoxicity of bioreductive agents determined in vitro by the MTT assay

1989 • 80 citations

The sensitivity of human tumour cells to quinone bioreductive drugs: What role for DT-diaphorase?

1992 • 77 citations

Enhancement of mitomycin C cytotoxicity to hypoxic tumor cells by dicoumarol in vivo and in vitro.

1985 • 71 citations

Keynote address: Bioreductive mechanisms

1992 • 69 citations

Enzymology of the reductive bioactivation of SR 4233

1990 • 69 citations

Bioactivation of Mitomycin C by Xanthine Dehydrogenase From EMT6 Mouse Mammary Carcinoma Tumors

1992 • 67 citations

Unusually marked hypoxic sensitization to indoloquinone E09 and mitomycin C in a human colon‐tumour cell line that lacks DT‐diaphorase activity

1994 • 66 citations

In vitro activity of the novel indoloquinone EO-9 and the influence of pH on cytotoxicity

1992 • 60 citations

Chinese hamster ovary cell lines resistant to mitomycin C under aerobic but not hypoxic conditions are deficient in DT-diaphorase.

1991 • 54 citations

Adducts of mitomycin C and DNA in EMT6 mouse mammary tumor cells: effects of hypoxia and dicumarol on adduct patterns.

1993 • 39 citations

Chemosensitivity to the indoloquinone EO9 is correlated with DT-diaphorase activity and its gene expression

1994 • 37 citations

Expression of rat liver NAD(P)H:quinone-acceptor oxidoreductase in Escherichia coli and mutagenesis in vitro at Arg-177

1992 • 27 citations

Site-directed mutagenesis of rat liver NAD(P)H: quinone oxidoreductase: Roles of lysine 76 and cysteine 179

1992 • 10 citations