Reductive activation of mitomycin C

A general mechanism for microsomal activation of quinone anticancer agents to free radicals.

1978 • 645 citations

Mitomycins and Porfiromycin: Chemical Mechanism of Activation and Cross-linking of DNA

1964 • 565 citations

A MOLECULAR MECHANISM OF MITOMYCIN ACTION: LINKING OF COMPLEMENTARY DNA STRANDS

1963 • 564 citations

Isolation and Structure of a Covalent Cross-Link Adduct Between Mitomycin C and DNA

1987 • 454 citations

Bioactivation as a Model for Drug Design Bioreductive Alkylation

1977 • 432 citations

Free radicals, aging, and degenerative diseases

1986 • 311 citations

One-electron reactions in biochemical systems as studied by pulse radiolysis. II. Riboflavine

1969 • 259 citations

Pulse radiolysis apparatus

1964 • 225 citations

Reductive activation of mitomycin C and mitomycin C metabolites catalyzed by NADPH-cytochrome P-450 reductase and xanthine oxidase.

1984 • 214 citations

Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1.

1984 • 178 citations

Studies related to antitumor antibiotics. Part V. Reactions of mitomycin C with DNA examined by ethidium fluorescence assay

1976 • 167 citations

Reaction of DNA with chemically or enzymatically activated mitomycin C: isolation and structure of the major covalent adduct.

1986 • 144 citations

Reductive metabolism and alkylating activity of mitomycin C induced by rat liver microsomes

1981 • 132 citations

Reactions of the semiquinone free radicals of anti‐tumour agents with oxygen and iron complexes

1985 • 86 citations

pH dependence of mitomycin C-induced cross-linking activity in EMT6 tumor cells.

1985 • 78 citations

Chemistry and Structure of Mitomycin C¹

1965 • 76 citations

Enhancement of mitomycin C cytotoxicity to hypoxic tumor cells by dicoumarol in vivo and in vitro.

1985 • 71 citations

The one-electron reduction potentials of NAD

1980 • 69 citations

Alkylation reactions of mitomycin C at acid pH

1979 • 67 citations

DNA alkylation by enzyme-activated mitomycin C.

1986 • 57 citations

Electrochemical reductive activation of mitomycin C

1986 • 56 citations

Autocatalytic quinone methide formation from mitomycin c

1986 • 53 citations

Modeling of the electrophilic activation of mitomycins: chemical evidence for the intermediacy of a mitosene semiquinone as the active electrophile

1987 • 42 citations

Possible intermediates in the action of adriamycin—A pulse radiolysis study

1985 • 41 citations

Kinetics and mechanism of the acid hydrolysis of mitomycins

1985 • 34 citations

Mutagenic chemistry of heteroaromatic amines and mitomycin C

1984 • 32 citations

Mechanistic studies on the mode of reaction of mitomycin C under catalytic and electrochemical reductive conditions

1987 • 31 citations

Nature of the destruction of deoxyguanosine residues by mitomycin C

1985 • 22 citations

Covalent binding of mitomycin C to nucleosides under reductive conditions

1987 • 14 citations

Process Catalysts Continue on Steady Course

1986 • 12 citations