Human erythroid 5-aminolevulinate synthase: promoter analysis and identification of an iron-responsive element in the mRNA.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs

1984 • 3,334 citations

Iron-Responsive Elements: Regulatory RNA Sequences That Control mRNA Levels and Translation

1988 • 707 citations

The thyroid hormone receptor binds with opposite transcriptional effects to a common sequence motif in thyroid hormone and estrogen response elements

1988 • 679 citations

Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: Identification of an upstream control region

1981 • 646 citations

Three regions upstream from the cap site are required for efficient and accurate transcription of the rabbit β-globin gene in mouse 3T6 cells

1983 • 596 citations

A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA

1989 • 511 citations

Fine Structure Genetic Analysis of a β-Globin Promoter

1986 • 479 citations

Globin gene regulation and switching: Circa 1990

1990 • 463 citations

Iron regulates ferritin mRNA translation through a segment of its 5' untranslated region.

1987 • 365 citations

The human beta-globin gene 3' enhancer contains multiple binding sites for an erythroid-specific protein.

1988 • 362 citations

Regulation of ferritin and transferrin receptor mRNAs.

1990 • 339 citations

Iron regulation of transferrin receptor mRNA levels requires iron-responsive elements and a rapid turnover determinant in the 3′ untranslated region of the mRNA.

1989 • 334 citations

Two tissue-specific factors bind the erythroid promoter of the human porphobilinogen deaminase gene

1989 • 326 citations

Alternative transcription and splicing of the human porphobilinogen deaminase gene result either in tissue-specific or in housekeeping expression.

1988 • 313 citations

Increased γ-globin expression in a nondeletion HPFH mediated by an erythroid-specif ic DNA-binding factor

1989 • 298 citations

The beta-globin dominant control region: hypersensitive site 2.

1990 • 295 citations

Cis- and trans-acting elements involved in the regulation of the erythroid promoter of the human porphobilinogen deaminase gene.

1989 • 272 citations

A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron.

1987 • 250 citations

v-erbA oncogene activation entails the loss of hormone-dependent regulator activity of c-erbA

1990 • 236 citations

The human beta-globin promoter; nuclear protein factors and erythroid specific induction of transcription.

1988 • 211 citations

DEVELOPMENTAL REGULATION OF HUMAN GLOBIN GENES

1985 • 190 citations

Analysis of the 5′ regulatory region of the gene for δ-aminolevulinic acid synthetase ofRhizobium meliloti

1985 • 165 citations

Expression of delta-aminolevulinate synthase in avian cells: separate genes encode erythroid-specific and nonspecific isozymes.

1989 • 163 citations

Human δ-aminolevulinate synthase: Assignment of the housekeeping gene to 3p21 and the erythroid-specific gene to the X chromosome

1990 • 162 citations

Pathophysiology of heme synthesis.

1988 • 148 citations

Translational repression by a complex between the iron-responsive element of ferritin mRNA and its specific cytoplasmic binding protein is position-dependent in vivo.

1990 • 147 citations

Inducibility of the HS II enhancer depends on binding of an erythroid specific nuclear protein

1990 • 140 citations

Cloning and complete nucleotide sequence of human 5'-alpha-globin gene.

1980 • 136 citations

The mRNA-binding protein which controls ferritin and transferrin receptor expression is conserved during evolution

1990 • 125 citations

Structural requirements of iron-responsive elements for binding of the protein involved in both transferrin receptor and ferritin mRNA post-transcriptional regulation

1990 • 114 citations

Determinants of the interaction between the iron-responsive element-binding protein and its binding site in rat L-ferritin mRNA.

1990 • 112 citations

Regulation of 5-aminolevulinate synthase mRNA in different rat tissues.

1988 • 108 citations

Molecular cloning and nucleotide sequence of a complete human uroporphyrinogen decarboxylase cDNA.

1986 • 107 citations

Identification of the enzymatic basis for delta-aminolevulinic acid auxotrophy in a hemA mutant of Escherichia coli

1989 • 97 citations

Characterization and evolution of the expressed rat ferritin light subunit gene and its pseudogene family. Conservation of sequences within noncoding regions of ferritin genes.

1987 • 95 citations

In vitro-derived leukemic erythroid cell lines induced by a raf- and myc-containing retrovirus differentiate in response to erythropoietin.

1988 • 93 citations

Erythroid 5-aminolevulinate synthase is located on the X chromosome.

1990 • 89 citations

The iron-responsive element is the single element responsible for iron-dependent translational regulation of ferritin biosynthesis. Evidence for function as the binding site for a translational repressor.

1988 • 87 citations

Nucleotide sequence of mouse 5-aminolevulinic acid synthase cDNA and expression of its gene in hepatic and erythroid tissues

1986 • 85 citations

Structure of the Bradyrhizobium japonicum gene hemA encoding 5-aminolevulinic acid synthase

1987 • 81 citations

Complete nucleotide sequence of hepatic 5-aminolaevulinate synthase precursor

1985 • 69 citations

Structure of the 5' untranslated regulatory region of ferritin mRNA studied in solution

1990 • 67 citations

Molecular regulation of 5-aminolevulinate synthase. Diseases related to heme biosynthesis.

1990 • 66 citations

The nucleotide sequence of the HEM1 gene and evidence for a precursor form of the mitochondrial 5-aminolevulinate synthase in Saccharomyces cerevisiae

1986 • 64 citations

Nudeotide sequence of the chicken 5-aminolevulinate synthase gene

1986 • 63 citations

5-Aminolevulinate synthase is at 3p21 and thus not the primary defect in X-linked sideroblastic anemia.

1988 • 56 citations

Structure of a mouse erythroid 5-aminolevulinate synthase gene and mapping of erythroid-specific DNAse I hypersensitive sites

1989 • 51 citations

Sequence of human 5-amlnoievulinate synthase cDNA

1987 • 46 citations

Effects of succinylacetone on dimethylsulfoxide-mediated induction of heme pathway enzymes in mouse Friend virus-transformed erythroleukemia cells

1984 • 46 citations

Biosynthesis of heme in immature erythroid cells. The regulatory step for heme formation in the human erythron.

1988 • 40 citations

Regulation of 5-aminolevulinate synthase in mouse erythroleukemic cells is different from that in liver.

1988 • 30 citations

Haem inhibits iron uptake subsequent to endocytosis of transferrin in reticulocytes

1988 • 26 citations

Regulated expression of the overlapping ubiquitous and erythroid transcription units of the human porphobilinogen deaminase (PBG-D) gene introduced into non-erythroid and erythroid cells

1989 • 18 citations